Sensitivity of Alpha-Methylacyl-COA Racemase (AMACR) Staining in Prostatic Adenocarcinoma
OBJECTIVES: To determine the sensitivity of Immunohistochemistry for confirmation of diagnosis of prostate adenocarcinoma in our setup. METHODOLOGY: This descriptive cross sectional study was conducted at Pathology Department of Shaukat Khanum Memorial Cancer Hospital and Research Center, in a peri...
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| Format: | Article |
| Language: | English |
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Liaquat University of Medical and Health Sciences
2020-12-01
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| Series: | JLUMHS |
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| Online Access: | https://www.lumhs.edu.pk/jlumhs/Vol19No04/12.pdf |
| _version_ | 1797821349508415488 |
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| author | Suresh Kumar Uzma Bukhari Bushra Sikandar Aneeta George Yusra Memon Nehad Khan |
| author_facet | Suresh Kumar Uzma Bukhari Bushra Sikandar Aneeta George Yusra Memon Nehad Khan |
| author_sort | Suresh Kumar |
| collection | DOAJ |
| description | OBJECTIVES: To determine the sensitivity of Immunohistochemistry for confirmation of diagnosis of prostate adenocarcinoma in our setup.
METHODOLOGY: This descriptive cross sectional study was conducted at Pathology Department of Shaukat Khanum Memorial Cancer Hospital and Research Center, in a period of six months from September 2012 to March 2013, taking a sample size of 80 biopsy proven cases of prostatic Adenocarcinoma with Non-probability purposive sampling technique. SPSS version 16 was used for data analysis. The qualitative variables like expression of AMACR were presented as frequencies and percentages. Chi square was used with a p value <0.05 taken as significant.
RESULTS: The mean ± SD age of patients was 67.81±7.25 years with a range from 51 to 85 years. The mean ± SD Gleason score of these patients was 6.99±1.52. About 51.2% (n=41) patients were of age group 61-70 years, 33.8% (n=27) were between 71-80 years, only 2.5% (n=2) were of age 81 years and above. Well-differentiated cases of prostatic adenocarcinoma were 3.8% (n=3), 52.5% (n=42) were moderately while 43.8% (n=35) were poorly differentiated. Out of all 100% (n=80) cases 91.2% (n=73) were expressed positive with AMACR staining while remaining 8.8% (n=7) were AMACR negative.
CONCLUSION: AMACR staining is highly sensitive diagnostic tool and should be carried out in all patients who present with doubtful picture of prostatic cancer. |
| first_indexed | 2024-03-13T09:52:20Z |
| format | Article |
| id | doaj.art-497d7839f7114bbe9d18632adfe392bb |
| institution | Directory Open Access Journal |
| issn | 1729-0341 2309-8627 |
| language | English |
| last_indexed | 2024-03-13T09:52:20Z |
| publishDate | 2020-12-01 |
| publisher | Liaquat University of Medical and Health Sciences |
| record_format | Article |
| series | JLUMHS |
| spelling | doaj.art-497d7839f7114bbe9d18632adfe392bb2023-05-24T07:16:51ZengLiaquat University of Medical and Health SciencesJLUMHS1729-03412309-86272020-12-011904275279doi:10.22442/jlumhs.201940705Sensitivity of Alpha-Methylacyl-COA Racemase (AMACR) Staining in Prostatic AdenocarcinomaSuresh Kumar0Uzma Bukhari 1Bushra Sikandar 2Aneeta George 3Yusra Memon4Nehad Khan5Dow University of Medical & Health Sciences Karachi, Sindh-PakistanDow University of Medical & Health Sciences Karachi, Sindh-PakistanDow University of Medical & Health Sciences Karachi, Sindh-PakistanDow University of Health Sciences Karachi, Sindh-Pakistan.Dow University of Health Sciences Karachi, Sindh-Pakistan.Dow University of Health and Sciences Karachi, Sindh-Pakistan.OBJECTIVES: To determine the sensitivity of Immunohistochemistry for confirmation of diagnosis of prostate adenocarcinoma in our setup. METHODOLOGY: This descriptive cross sectional study was conducted at Pathology Department of Shaukat Khanum Memorial Cancer Hospital and Research Center, in a period of six months from September 2012 to March 2013, taking a sample size of 80 biopsy proven cases of prostatic Adenocarcinoma with Non-probability purposive sampling technique. SPSS version 16 was used for data analysis. The qualitative variables like expression of AMACR were presented as frequencies and percentages. Chi square was used with a p value <0.05 taken as significant. RESULTS: The mean ± SD age of patients was 67.81±7.25 years with a range from 51 to 85 years. The mean ± SD Gleason score of these patients was 6.99±1.52. About 51.2% (n=41) patients were of age group 61-70 years, 33.8% (n=27) were between 71-80 years, only 2.5% (n=2) were of age 81 years and above. Well-differentiated cases of prostatic adenocarcinoma were 3.8% (n=3), 52.5% (n=42) were moderately while 43.8% (n=35) were poorly differentiated. Out of all 100% (n=80) cases 91.2% (n=73) were expressed positive with AMACR staining while remaining 8.8% (n=7) were AMACR negative. CONCLUSION: AMACR staining is highly sensitive diagnostic tool and should be carried out in all patients who present with doubtful picture of prostatic cancer.https://www.lumhs.edu.pk/jlumhs/Vol19No04/12.pdfamacr stainingprostatic adenocarcinomapsagleason scoringimmunohistochemistry. |
| spellingShingle | Suresh Kumar Uzma Bukhari Bushra Sikandar Aneeta George Yusra Memon Nehad Khan Sensitivity of Alpha-Methylacyl-COA Racemase (AMACR) Staining in Prostatic Adenocarcinoma JLUMHS amacr staining prostatic adenocarcinoma psa gleason scoring immunohistochemistry. |
| title | Sensitivity of Alpha-Methylacyl-COA Racemase (AMACR) Staining in Prostatic Adenocarcinoma |
| title_full | Sensitivity of Alpha-Methylacyl-COA Racemase (AMACR) Staining in Prostatic Adenocarcinoma |
| title_fullStr | Sensitivity of Alpha-Methylacyl-COA Racemase (AMACR) Staining in Prostatic Adenocarcinoma |
| title_full_unstemmed | Sensitivity of Alpha-Methylacyl-COA Racemase (AMACR) Staining in Prostatic Adenocarcinoma |
| title_short | Sensitivity of Alpha-Methylacyl-COA Racemase (AMACR) Staining in Prostatic Adenocarcinoma |
| title_sort | sensitivity of alpha methylacyl coa racemase amacr staining in prostatic adenocarcinoma |
| topic | amacr staining prostatic adenocarcinoma psa gleason scoring immunohistochemistry. |
| url | https://www.lumhs.edu.pk/jlumhs/Vol19No04/12.pdf |
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