Non-coding RNAs: Important participants in cardiac fibrosis
Cardiac remodeling is a pathophysiological process activated by diverse cardiac stress, which impairs cardiac function and leads to adverse clinical outcome. This remodeling partly attributes to cardiac fibrosis, which is a result of differentiation of cardiac fibroblasts to myofibroblasts and the p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.937995/full |
| _version_ | 1828359488920354816 |
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| author | Yiheng Dong Naling Peng Lini Dong Shengyu Tan Xiangyu Zhang |
| author_facet | Yiheng Dong Naling Peng Lini Dong Shengyu Tan Xiangyu Zhang |
| author_sort | Yiheng Dong |
| collection | DOAJ |
| description | Cardiac remodeling is a pathophysiological process activated by diverse cardiac stress, which impairs cardiac function and leads to adverse clinical outcome. This remodeling partly attributes to cardiac fibrosis, which is a result of differentiation of cardiac fibroblasts to myofibroblasts and the production of excessive extracellular matrix within the myocardium. Non-coding RNAs mainly include microRNAs and long non-coding RNAs. These non-coding RNAs have been proved to have a profound impact on biological behaviors of various cardiac cell types and play a pivotal role in the development of cardiac fibrosis. This review aims to summarize the role of microRNAs and long non-coding RNAs in cardiac fibrosis associated with pressure overload, ischemia, diabetes mellitus, aging, atrial fibrillation and heart transplantation, meanwhile shed light on the diagnostic and therapeutic potential of non-coding RNAs for cardiac fibrosis. |
| first_indexed | 2024-04-14T03:43:09Z |
| format | Article |
| id | doaj.art-4980967580604c388b7e1ed83b0a6b81 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-14T03:43:09Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-4980967580604c388b7e1ed83b0a6b812022-12-22T02:14:26ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-07-01910.3389/fcvm.2022.937995937995Non-coding RNAs: Important participants in cardiac fibrosisYiheng DongNaling PengLini DongShengyu TanXiangyu ZhangCardiac remodeling is a pathophysiological process activated by diverse cardiac stress, which impairs cardiac function and leads to adverse clinical outcome. This remodeling partly attributes to cardiac fibrosis, which is a result of differentiation of cardiac fibroblasts to myofibroblasts and the production of excessive extracellular matrix within the myocardium. Non-coding RNAs mainly include microRNAs and long non-coding RNAs. These non-coding RNAs have been proved to have a profound impact on biological behaviors of various cardiac cell types and play a pivotal role in the development of cardiac fibrosis. This review aims to summarize the role of microRNAs and long non-coding RNAs in cardiac fibrosis associated with pressure overload, ischemia, diabetes mellitus, aging, atrial fibrillation and heart transplantation, meanwhile shed light on the diagnostic and therapeutic potential of non-coding RNAs for cardiac fibrosis.https://www.frontiersin.org/articles/10.3389/fcvm.2022.937995/fullnon-coding RNAmicroRNAlong non-coding RNAcardiac fibrosisbiomarkercardiac remodeling |
| spellingShingle | Yiheng Dong Naling Peng Lini Dong Shengyu Tan Xiangyu Zhang Non-coding RNAs: Important participants in cardiac fibrosis Frontiers in Cardiovascular Medicine non-coding RNA microRNA long non-coding RNA cardiac fibrosis biomarker cardiac remodeling |
| title | Non-coding RNAs: Important participants in cardiac fibrosis |
| title_full | Non-coding RNAs: Important participants in cardiac fibrosis |
| title_fullStr | Non-coding RNAs: Important participants in cardiac fibrosis |
| title_full_unstemmed | Non-coding RNAs: Important participants in cardiac fibrosis |
| title_short | Non-coding RNAs: Important participants in cardiac fibrosis |
| title_sort | non coding rnas important participants in cardiac fibrosis |
| topic | non-coding RNA microRNA long non-coding RNA cardiac fibrosis biomarker cardiac remodeling |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.937995/full |
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