Myocarditis and Subclinical-Like Infection Associated With SARS-CoV-2 in Two Cats Living in the Same Household in France: A Case Report With Literature Review
This report provides the first clinical, radiographic, echocardiographic, and biological description of SARS-CoV-2-associated myocarditis with a 6-month follow-up in a 5-year-old obese male domestic shorthair cat (Cat-1) presented for refractory congestive heart failure, with high cardiac troponin-I...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2021.748869/full |
| _version_ | 1818585182134861824 |
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| author | Valérie Chetboul Valérie Chetboul Pierre Foulex Kahina Kartout Anne Marie Klein Corinne Sailleau Marine Dumarest Manon Delaplace Meriadeg Ar Gouilh Jeremy Mortier Sophie Le Poder |
| author_facet | Valérie Chetboul Valérie Chetboul Pierre Foulex Kahina Kartout Anne Marie Klein Corinne Sailleau Marine Dumarest Manon Delaplace Meriadeg Ar Gouilh Jeremy Mortier Sophie Le Poder |
| author_sort | Valérie Chetboul |
| collection | DOAJ |
| description | This report provides the first clinical, radiographic, echocardiographic, and biological description of SARS-CoV-2-associated myocarditis with a 6-month follow-up in a 5-year-old obese male domestic shorthair cat (Cat-1) presented for refractory congestive heart failure, with high cardiac troponin-I level (5.24 ng/ml), and a large lingual ulcer. The animal was SARS-CoV-2 positive on serology. The other cat living in the same household (Cat-2) never showed any clinical sign but was also confirmed SARS-CoV-2 positive on serology. Both cats were SARS-CoV-2 PCR negative. Cat-1 had closer contact than Cat-2 with their owner, who had been in close contact with a coworker tested PCR positive for COVID-19 (Alpha (B.1.1.7) variant) 4 weeks before Cat-1's first episode of congestive heart failure. A focused point-of-care echocardiography at presentation revealed for Cat-1 numerous B-lines, pleural effusion, severe left atrial dilation and dysfunction, and hypertrophic cardiomyopathy phenotype associated with focal pulmonary consolidations. Both myocarditis and pneumonia were suspected, leading to the prescription of cardiac medications and antibiotics. One month later, Cat-1 recovered, with normalization of left atrial size and function, and radiographic and echocardiography disappearance of heart failure signs and pulmonary lesions. An extensive literature review of SARS-CoV-2-related cardiac injury in pets in comparison with human pathology is discussed. |
| first_indexed | 2024-12-16T08:33:00Z |
| format | Article |
| id | doaj.art-4981aba6a5c24a9e981c1e04e4ad1c69 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-16T08:33:00Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-4981aba6a5c24a9e981c1e04e4ad1c692022-12-21T22:37:49ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692021-10-01810.3389/fvets.2021.748869748869Myocarditis and Subclinical-Like Infection Associated With SARS-CoV-2 in Two Cats Living in the Same Household in France: A Case Report With Literature ReviewValérie Chetboul0Valérie Chetboul1Pierre Foulex2Kahina Kartout3Anne Marie Klein4Corinne Sailleau5Marine Dumarest6Manon Delaplace7Meriadeg Ar Gouilh8Jeremy Mortier9Sophie Le Poder10École Nationale Vétérinaire d'Alfort, CHUVA, Unité de Cardiologie d'Alfort (UCA), Maisons-Alfort, FranceUniversité Paris Est Créteil, INSERM, IMRB, Créteil, FranceÉcole Nationale Vétérinaire d'Alfort, CHUVA, Unité de Cardiologie d'Alfort (UCA), Maisons-Alfort, FranceÉcole Nationale Vétérinaire d'Alfort, CHUVA, Unité de Cardiologie d'Alfort (UCA), Maisons-Alfort, FranceClinique Vétérinaire, Paris, FranceÉcole Nationale Vétérinaire d'Alfort, UMR VIROLOGIE, INRAE, ANSES, Laboratoire de santé animale, Université Paris-Est, Maisons-Alfort, FranceÉcole Nationale Vétérinaire d'Alfort, UMR VIROLOGIE, INRAE, ANSES, Laboratoire de santé animale, Université Paris-Est, Maisons-Alfort, FranceÉcole Nationale Vétérinaire d'Alfort, UMR VIROLOGIE, INRAE, ANSES, Laboratoire de santé animale, Université Paris-Est, Maisons-Alfort, FranceGroupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Normandie Université, UNICAEN, 13 UNIROUEN, Caen, FranceÉcole Nationale Vétérinaire d'Alfort, CHUVA, Service d'Imagerie Médicale, Maisons-Alfort, FranceÉcole Nationale Vétérinaire d'Alfort, UMR VIROLOGIE, INRAE, ANSES, Laboratoire de santé animale, Université Paris-Est, Maisons-Alfort, FranceThis report provides the first clinical, radiographic, echocardiographic, and biological description of SARS-CoV-2-associated myocarditis with a 6-month follow-up in a 5-year-old obese male domestic shorthair cat (Cat-1) presented for refractory congestive heart failure, with high cardiac troponin-I level (5.24 ng/ml), and a large lingual ulcer. The animal was SARS-CoV-2 positive on serology. The other cat living in the same household (Cat-2) never showed any clinical sign but was also confirmed SARS-CoV-2 positive on serology. Both cats were SARS-CoV-2 PCR negative. Cat-1 had closer contact than Cat-2 with their owner, who had been in close contact with a coworker tested PCR positive for COVID-19 (Alpha (B.1.1.7) variant) 4 weeks before Cat-1's first episode of congestive heart failure. A focused point-of-care echocardiography at presentation revealed for Cat-1 numerous B-lines, pleural effusion, severe left atrial dilation and dysfunction, and hypertrophic cardiomyopathy phenotype associated with focal pulmonary consolidations. Both myocarditis and pneumonia were suspected, leading to the prescription of cardiac medications and antibiotics. One month later, Cat-1 recovered, with normalization of left atrial size and function, and radiographic and echocardiography disappearance of heart failure signs and pulmonary lesions. An extensive literature review of SARS-CoV-2-related cardiac injury in pets in comparison with human pathology is discussed.https://www.frontiersin.org/articles/10.3389/fvets.2021.748869/fullcatCOVID-19echocardiographyheart failuremyocarditisSARS-CoV-2 |
| spellingShingle | Valérie Chetboul Valérie Chetboul Pierre Foulex Kahina Kartout Anne Marie Klein Corinne Sailleau Marine Dumarest Manon Delaplace Meriadeg Ar Gouilh Jeremy Mortier Sophie Le Poder Myocarditis and Subclinical-Like Infection Associated With SARS-CoV-2 in Two Cats Living in the Same Household in France: A Case Report With Literature Review Frontiers in Veterinary Science cat COVID-19 echocardiography heart failure myocarditis SARS-CoV-2 |
| title | Myocarditis and Subclinical-Like Infection Associated With SARS-CoV-2 in Two Cats Living in the Same Household in France: A Case Report With Literature Review |
| title_full | Myocarditis and Subclinical-Like Infection Associated With SARS-CoV-2 in Two Cats Living in the Same Household in France: A Case Report With Literature Review |
| title_fullStr | Myocarditis and Subclinical-Like Infection Associated With SARS-CoV-2 in Two Cats Living in the Same Household in France: A Case Report With Literature Review |
| title_full_unstemmed | Myocarditis and Subclinical-Like Infection Associated With SARS-CoV-2 in Two Cats Living in the Same Household in France: A Case Report With Literature Review |
| title_short | Myocarditis and Subclinical-Like Infection Associated With SARS-CoV-2 in Two Cats Living in the Same Household in France: A Case Report With Literature Review |
| title_sort | myocarditis and subclinical like infection associated with sars cov 2 in two cats living in the same household in france a case report with literature review |
| topic | cat COVID-19 echocardiography heart failure myocarditis SARS-CoV-2 |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2021.748869/full |
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