Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients
<i>Background and Objectives</i>: Omentin-1, also known as intelectin-1, is a novel adipokine with anti-inflammatory activities implicated in inflammatory diseases and sepsis. We aimed to explore serum omentin-1 and its kinetics in critically ill patients early in sepsis and its associat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/5/833 |
| _version_ | 1797599186390089728 |
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| author | Irene Karampela Natalia G. Vallianou Dimitrios Tsilingiris Gerasimos Socrates Christodoulatos Georgios Antonakos Ioanna Marinou Evaggelos Vogiatzakis Apostolos Armaganidis Maria Dalamaga |
| author_facet | Irene Karampela Natalia G. Vallianou Dimitrios Tsilingiris Gerasimos Socrates Christodoulatos Georgios Antonakos Ioanna Marinou Evaggelos Vogiatzakis Apostolos Armaganidis Maria Dalamaga |
| author_sort | Irene Karampela |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Omentin-1, also known as intelectin-1, is a novel adipokine with anti-inflammatory activities implicated in inflammatory diseases and sepsis. We aimed to explore serum omentin-1 and its kinetics in critically ill patients early in sepsis and its association with severity and prognosis. <i>Materials and Methods</i>: Serum omentin-1 was determined in 102 critically ill patients with sepsis during the first 48 h from sepsis onset and 1 week later, and in 102 age- and gender-matched healthy controls. The outcome of sepsis at 28 days after enrollment was recorded. <i>Results</i>: Serum omentin-1 at enrollment was significantly higher in patients compared to controls (763.3 ± 249.3 vs. 451.7 ± 122.3 μg/L, <i>p</i> < 0.001) and it further increased 1 week after (950.6 ± 215.5 vs. 763.3 ± 249.3 μg/L, <i>p</i> < 0.001). Patients with septic shock (<i>n</i> = 42) had higher omentin-1 compared to those with sepsis (<i>n</i> = 60) at enrollment (877.9 ± 241.2 vs. 683.1 ± 223.7 μg/L, <i>p</i> < 0.001) and 1 week after (1020.4 ± 224.7 vs. 901.7 ± 196.3 μg/L, <i>p</i> = 0.007). Furthermore, nonsurvivors (<i>n</i> = 30) had higher omentin-1 at sepsis onset (952.1 ± 248.2 vs. 684.6 ± 204.7 μg/L, <i>p</i> < 0.001) and 1 week after (1051.8 ± 242 vs. 908.4 ± 189.8 μg/L, <i>p</i> < 0.01). Patients with sepsis and survivors presented higher kinetics than those with septic shock and nonsurvivors (Δ(omentin-1)% 39.8 ± 35.9% vs. 20.2 ± 23.3%, <i>p</i> = 0.01, and 39.4 ± 34.3% vs. 13.3 ± 18.1%, <i>p</i> < 0.001, respectively). Higher omentin-1 at sepsis onset and 1 week after was an independent predictor of 28-day mortality (HR 2.26, 95% C.I. 1.21–4.19, <i>p</i> = 0.01 and HR: 2.15, 95% C.I. 1.43–3.22, <i>p</i> < 0.001, respectively). Finally, omentin-1 was significantly correlated with the severity scores, the white blood cells, coagulation biomarkers, and CRP, but not procalcitonin and other inflammatory biomarkers. <i>Conclusions</i>: Serum omentin-1 is increased in sepsis, while higher levels and lower kinetics during the first week of sepsis are associated with the severity and 28-day mortality of sepsis. Omentin-1 may be a promising biomarker of sepsis. However, more studies are needed to explore its role in sepsis. |
| first_indexed | 2024-03-11T03:31:11Z |
| format | Article |
| id | doaj.art-498269c7c3304c529087a3d18ec68fc0 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T03:31:11Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-498269c7c3304c529087a3d18ec68fc02023-11-18T02:20:52ZengMDPI AGMedicina1010-660X1648-91442023-04-0159583310.3390/medicina59050833Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill PatientsIrene Karampela0Natalia G. Vallianou1Dimitrios Tsilingiris2Gerasimos Socrates Christodoulatos3Georgios Antonakos4Ioanna Marinou5Evaggelos Vogiatzakis6Apostolos Armaganidis7Maria Dalamaga8Second Department of Critical Care, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceFirst Department of Internal Medicine, Evangelismos General Hospital, 10676 Athens, GreeceFirst Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceLaboratory of Clinical Biochemistry, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceLaboratory of Microbiology, Sotiria Athens General Hospital, 11527 Athens, GreeceLaboratory of Microbiology, Sotiria Athens General Hospital, 11527 Athens, GreeceSecond Department of Critical Care, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece<i>Background and Objectives</i>: Omentin-1, also known as intelectin-1, is a novel adipokine with anti-inflammatory activities implicated in inflammatory diseases and sepsis. We aimed to explore serum omentin-1 and its kinetics in critically ill patients early in sepsis and its association with severity and prognosis. <i>Materials and Methods</i>: Serum omentin-1 was determined in 102 critically ill patients with sepsis during the first 48 h from sepsis onset and 1 week later, and in 102 age- and gender-matched healthy controls. The outcome of sepsis at 28 days after enrollment was recorded. <i>Results</i>: Serum omentin-1 at enrollment was significantly higher in patients compared to controls (763.3 ± 249.3 vs. 451.7 ± 122.3 μg/L, <i>p</i> < 0.001) and it further increased 1 week after (950.6 ± 215.5 vs. 763.3 ± 249.3 μg/L, <i>p</i> < 0.001). Patients with septic shock (<i>n</i> = 42) had higher omentin-1 compared to those with sepsis (<i>n</i> = 60) at enrollment (877.9 ± 241.2 vs. 683.1 ± 223.7 μg/L, <i>p</i> < 0.001) and 1 week after (1020.4 ± 224.7 vs. 901.7 ± 196.3 μg/L, <i>p</i> = 0.007). Furthermore, nonsurvivors (<i>n</i> = 30) had higher omentin-1 at sepsis onset (952.1 ± 248.2 vs. 684.6 ± 204.7 μg/L, <i>p</i> < 0.001) and 1 week after (1051.8 ± 242 vs. 908.4 ± 189.8 μg/L, <i>p</i> < 0.01). Patients with sepsis and survivors presented higher kinetics than those with septic shock and nonsurvivors (Δ(omentin-1)% 39.8 ± 35.9% vs. 20.2 ± 23.3%, <i>p</i> = 0.01, and 39.4 ± 34.3% vs. 13.3 ± 18.1%, <i>p</i> < 0.001, respectively). Higher omentin-1 at sepsis onset and 1 week after was an independent predictor of 28-day mortality (HR 2.26, 95% C.I. 1.21–4.19, <i>p</i> = 0.01 and HR: 2.15, 95% C.I. 1.43–3.22, <i>p</i> < 0.001, respectively). Finally, omentin-1 was significantly correlated with the severity scores, the white blood cells, coagulation biomarkers, and CRP, but not procalcitonin and other inflammatory biomarkers. <i>Conclusions</i>: Serum omentin-1 is increased in sepsis, while higher levels and lower kinetics during the first week of sepsis are associated with the severity and 28-day mortality of sepsis. Omentin-1 may be a promising biomarker of sepsis. However, more studies are needed to explore its role in sepsis.https://www.mdpi.com/1648-9144/59/5/833adipokineadipose tissuebiomarkercritically illintelectin-1mortality |
| spellingShingle | Irene Karampela Natalia G. Vallianou Dimitrios Tsilingiris Gerasimos Socrates Christodoulatos Georgios Antonakos Ioanna Marinou Evaggelos Vogiatzakis Apostolos Armaganidis Maria Dalamaga Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients Medicina adipokine adipose tissue biomarker critically ill intelectin-1 mortality |
| title | Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients |
| title_full | Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients |
| title_fullStr | Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients |
| title_full_unstemmed | Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients |
| title_short | Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients |
| title_sort | diagnostic and prognostic value of serum omentin 1 in sepsis a prospective study in critically ill patients |
| topic | adipokine adipose tissue biomarker critically ill intelectin-1 mortality |
| url | https://www.mdpi.com/1648-9144/59/5/833 |
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