Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response
Infection by protozoan parasites is part of the most common Tropical Neglected Diseases. In the case of leishmaniasis, several millions of people are at risk of contracting the disease. In spite of innumerous studies that elucidated the immune response capable of killing the parasite, the understand...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-08-01
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| Series: | Biomedical Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417016300385 |
| _version_ | 1811182858246553600 |
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| author | Amanda Braga de Figueiredo Miriam Conceicao Souza-Testasicca Luis Carlos Crocco Afonso |
| author_facet | Amanda Braga de Figueiredo Miriam Conceicao Souza-Testasicca Luis Carlos Crocco Afonso |
| author_sort | Amanda Braga de Figueiredo |
| collection | DOAJ |
| description | Infection by protozoan parasites is part of the most common Tropical Neglected Diseases. In the case of leishmaniasis, several millions of people are at risk of contracting the disease. In spite of innumerous studies that elucidated the immune response capable of killing the parasite, the understanding of the evasion mechanisms utilized by the parasite to survive within the very cell responsible for its destruction is still incomplete. In this review, we offer a new approach to the control of the immune response against the parasite. The ability of the parasite to modulate the levels of extracellular ATP and adenosine either by directly acting on the levels of these molecules or by inducing the expression of CD39 and CD73 on the infected cell may influence the magnitude of the immune response against the parasite contributing to its growth and survival. Keywords: Leishmania, Innate response, Immune evasion, Purinergic signaling |
| first_indexed | 2024-04-11T09:38:41Z |
| format | Article |
| id | doaj.art-4985ad69a9514c919073a94dd67b4799 |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-04-11T09:38:41Z |
| publishDate | 2016-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-4985ad69a9514c919073a94dd67b47992022-12-22T04:31:27ZengElsevierBiomedical Journal2319-41702016-08-01394244250Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune responseAmanda Braga de Figueiredo0Miriam Conceicao Souza-Testasicca1Luis Carlos Crocco Afonso2Immunoparasitology Laboratory, Department of Biological Sciences, ICEB/NUPEB, Federal University of Ouro Preto, BrazilCoordination Area of Biological Sciences, Federal Institute of Minas Gerais, BrazilImmunoparasitology Laboratory, Department of Biological Sciences, ICEB/NUPEB, Federal University of Ouro Preto, Brazil; Corresponding author. Immunoparasitology Laboratory, Department of Biological Sciences, ICEB/NUPEB, Federal University of Ouro Preto, Cruise hill, 35400-000 Ouro Preto, MG, Brazil. Tel.: +55 31 35591701; fax: +55 31 35591680.Infection by protozoan parasites is part of the most common Tropical Neglected Diseases. In the case of leishmaniasis, several millions of people are at risk of contracting the disease. In spite of innumerous studies that elucidated the immune response capable of killing the parasite, the understanding of the evasion mechanisms utilized by the parasite to survive within the very cell responsible for its destruction is still incomplete. In this review, we offer a new approach to the control of the immune response against the parasite. The ability of the parasite to modulate the levels of extracellular ATP and adenosine either by directly acting on the levels of these molecules or by inducing the expression of CD39 and CD73 on the infected cell may influence the magnitude of the immune response against the parasite contributing to its growth and survival. Keywords: Leishmania, Innate response, Immune evasion, Purinergic signalinghttp://www.sciencedirect.com/science/article/pii/S2319417016300385 |
| spellingShingle | Amanda Braga de Figueiredo Miriam Conceicao Souza-Testasicca Luis Carlos Crocco Afonso Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response Biomedical Journal |
| title | Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response |
| title_full | Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response |
| title_fullStr | Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response |
| title_full_unstemmed | Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response |
| title_short | Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response |
| title_sort | purinergic signaling and infection by leishmania a new approach to evasion of the immune response |
| url | http://www.sciencedirect.com/science/article/pii/S2319417016300385 |
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