Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes?
Background: Non-compliance and non-persistence with endocrine therapy for breast cancer is common and usually related to treatment-induced side effects. There are anecdotal reports that simply changing the time of day when taking endocrine therapy (i.e., changing morning dosing to evening dosing or...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/28/4/229 |
| _version_ | 1797520738441232384 |
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| author | Ana-Alicia Beltran-Bless Lisa Vandermeer Mohammed F. K. Ibrahim Brian Hutton Risa Shorr Marie-France Savard Mark Clemons |
| author_facet | Ana-Alicia Beltran-Bless Lisa Vandermeer Mohammed F. K. Ibrahim Brian Hutton Risa Shorr Marie-France Savard Mark Clemons |
| author_sort | Ana-Alicia Beltran-Bless |
| collection | DOAJ |
| description | Background: Non-compliance and non-persistence with endocrine therapy for breast cancer is common and usually related to treatment-induced side effects. There are anecdotal reports that simply changing the time of day when taking endocrine therapy (i.e., changing morning dosing to evening dosing or vice versa) can reduce side effects. Literature review: We conducted a literature review to evaluate whether changing the timing of tamoxifen and/or aromatase inhibitor administration impacted patient outcomes. No randomized control trials or prospective cohort studies that looked at time of day of endocrine therapy were identified through our review of literature from 1947 until August 2020. Conclusions: Given the rates of endocrine therapy non-compliance and non-persistence reported in the literature, ranging from 41–72% and 31–73%, respectively, simply changing the time of day when medications are taken could be an important strategy. We could identify no trials evaluating the effect of changes in timing of administration of endocrine therapy on breast cancer patient outcomes. Randomized control trials are clearly indicated for this simple and cost-effective intervention. |
| first_indexed | 2024-03-10T08:00:53Z |
| format | Article |
| id | doaj.art-498739eb66ce433c8765d214bc59270a |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T08:00:53Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-498739eb66ce433c8765d214bc59270a2023-11-22T11:27:11ZengMDPI AGCurrent Oncology1198-00521718-77292021-07-012842523252810.3390/curroncol28040229Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes?Ana-Alicia Beltran-Bless0Lisa Vandermeer1Mohammed F. K. Ibrahim2Brian Hutton3Risa Shorr4Marie-France Savard5Mark Clemons6Division of Medical Oncology, Department of Medicine, University of Ottawa and the Ottawa Hospital, Ottawa, ON K1H 8L6, CanadaOttawa Hospital Research Institute, Ottawa, ON K1Y 4E9, CanadaDivision of Clinical Sciences, Medical Oncology, Northern Ontario School of Medicine, Thunder Bay, ON P7B 5E1, CanadaOttawa Hospital Research Institute, Ottawa, ON K1Y 4E9, CanadaOttawa Hospital, Ottawa, ON K1H 8L6, CanadaDivision of Medical Oncology, Department of Medicine, University of Ottawa and the Ottawa Hospital, Ottawa, ON K1H 8L6, CanadaDivision of Medical Oncology, Department of Medicine, University of Ottawa and the Ottawa Hospital, Ottawa, ON K1H 8L6, CanadaBackground: Non-compliance and non-persistence with endocrine therapy for breast cancer is common and usually related to treatment-induced side effects. There are anecdotal reports that simply changing the time of day when taking endocrine therapy (i.e., changing morning dosing to evening dosing or vice versa) can reduce side effects. Literature review: We conducted a literature review to evaluate whether changing the timing of tamoxifen and/or aromatase inhibitor administration impacted patient outcomes. No randomized control trials or prospective cohort studies that looked at time of day of endocrine therapy were identified through our review of literature from 1947 until August 2020. Conclusions: Given the rates of endocrine therapy non-compliance and non-persistence reported in the literature, ranging from 41–72% and 31–73%, respectively, simply changing the time of day when medications are taken could be an important strategy. We could identify no trials evaluating the effect of changes in timing of administration of endocrine therapy on breast cancer patient outcomes. Randomized control trials are clearly indicated for this simple and cost-effective intervention.https://www.mdpi.com/1718-7729/28/4/229tamoxifenaromatase inhibitorbreast cancerchronotherapyside effects |
| spellingShingle | Ana-Alicia Beltran-Bless Lisa Vandermeer Mohammed F. K. Ibrahim Brian Hutton Risa Shorr Marie-France Savard Mark Clemons Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? Current Oncology tamoxifen aromatase inhibitor breast cancer chronotherapy side effects |
| title | Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? |
| title_full | Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? |
| title_fullStr | Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? |
| title_full_unstemmed | Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? |
| title_short | Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? |
| title_sort | does the time of day at which endocrine therapy is taken affect breast cancer patient outcomes |
| topic | tamoxifen aromatase inhibitor breast cancer chronotherapy side effects |
| url | https://www.mdpi.com/1718-7729/28/4/229 |
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