Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release
In traditional pharmaceutics, drug–crystalline nanoparticles and drug–polymer composites are frequently explored for their ability to modify drug release profiles. In this study, a novel sort of hybrid with a coating of acyclovir crystalline nanoparticles on acyclovir-polyacrylonitrile composites wa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/24/4286 |
| _version_ | 1797501231700115456 |
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| author | He Lv Shiri Guo Gaoyi Zhang Wanli He Yonghui Wu Deng-Guang Yu |
| author_facet | He Lv Shiri Guo Gaoyi Zhang Wanli He Yonghui Wu Deng-Guang Yu |
| author_sort | He Lv |
| collection | DOAJ |
| description | In traditional pharmaceutics, drug–crystalline nanoparticles and drug–polymer composites are frequently explored for their ability to modify drug release profiles. In this study, a novel sort of hybrid with a coating of acyclovir crystalline nanoparticles on acyclovir-polyacrylonitrile composites was fabricated using modified, coaxial electrospinning processes. The developed acyclovir-polyacrylonitrile at the acyclovir nanohybrids was loaded with various amounts of acyclovir, which could be realized simply by adjusting the sheath fluid flow rates. Compared with the electrospun composite nanofibers from a single-fluid blending process, the nanohybrids showed advantages of modifying the acyclovir release profiles in the following aspects: (1) the initial release amount was more accurately and intentionally controlled; (2) the later sustained release was nearer to a zero-order kinetic process; and (3) the release amounts at different stages could be easily allocated by the sheath fluid flow rate. X-ray diffraction results verified that the acyclovir nanoparticles were in a crystalline state, and Fourier-transform infrared spectra verified that the drug acyclovir and the polymer polyacrylonitrile had a good compatibility. The protocols reported here could pave the way for developing new types of functional nanostructures. |
| first_indexed | 2024-03-10T03:15:25Z |
| format | Article |
| id | doaj.art-4987c5599e1647e18b23b148a8832bee |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T03:15:25Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-4987c5599e1647e18b23b148a8832bee2023-11-23T10:14:08ZengMDPI AGPolymers2073-43602021-12-011324428610.3390/polym13244286Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug ReleaseHe Lv0Shiri Guo1Gaoyi Zhang2Wanli He3Yonghui Wu4Deng-Guang Yu5School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, ChinaThe Department of Mechanical Engineering, Guangxi Technological College of Machinery and Electricity, Nanning 530007, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, ChinaIn traditional pharmaceutics, drug–crystalline nanoparticles and drug–polymer composites are frequently explored for their ability to modify drug release profiles. In this study, a novel sort of hybrid with a coating of acyclovir crystalline nanoparticles on acyclovir-polyacrylonitrile composites was fabricated using modified, coaxial electrospinning processes. The developed acyclovir-polyacrylonitrile at the acyclovir nanohybrids was loaded with various amounts of acyclovir, which could be realized simply by adjusting the sheath fluid flow rates. Compared with the electrospun composite nanofibers from a single-fluid blending process, the nanohybrids showed advantages of modifying the acyclovir release profiles in the following aspects: (1) the initial release amount was more accurately and intentionally controlled; (2) the later sustained release was nearer to a zero-order kinetic process; and (3) the release amounts at different stages could be easily allocated by the sheath fluid flow rate. X-ray diffraction results verified that the acyclovir nanoparticles were in a crystalline state, and Fourier-transform infrared spectra verified that the drug acyclovir and the polymer polyacrylonitrile had a good compatibility. The protocols reported here could pave the way for developing new types of functional nanostructures.https://www.mdpi.com/2073-4360/13/24/4286coaxial electrospinningstructural hybridspolymeric nanocompositesmodified releasemedicated nanomaterials |
| spellingShingle | He Lv Shiri Guo Gaoyi Zhang Wanli He Yonghui Wu Deng-Guang Yu Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release Polymers coaxial electrospinning structural hybrids polymeric nanocomposites modified release medicated nanomaterials |
| title | Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release |
| title_full | Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release |
| title_fullStr | Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release |
| title_full_unstemmed | Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release |
| title_short | Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release |
| title_sort | electrospun structural hybrids of acyclovir polyacrylonitrile at acyclovir for modifying drug release |
| topic | coaxial electrospinning structural hybrids polymeric nanocomposites modified release medicated nanomaterials |
| url | https://www.mdpi.com/2073-4360/13/24/4286 |
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