Prevention of endometrial cancer through lifestyle Interventions: A systematic review and synthesis
Endometrial cancer is the most common gynaecological malignancy in Australia. Epidemiological studies have widely documented the association of endometrial cancer with modifiable lifestyle risk factors, most notably obesity. However, preventative strategies for endometrial cancer have not been well...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578921002046 |
| _version_ | 1811329640581562368 |
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| author | Dayle Rundle-Thiele Sujal Shrestha Monika Janda |
| author_facet | Dayle Rundle-Thiele Sujal Shrestha Monika Janda |
| author_sort | Dayle Rundle-Thiele |
| collection | DOAJ |
| description | Endometrial cancer is the most common gynaecological malignancy in Australia. Epidemiological studies have widely documented the association of endometrial cancer with modifiable lifestyle risk factors, most notably obesity. However, preventative strategies for endometrial cancer have not been well reported. The objective of this systematic review was to identify interventions targeted towards modifiable lifestyle risk factors that may reduce the risk of endometrial cancer. Literature published in the past ten years (January 2010 – January 2021) was retrieved from PubMed, Embase and Web of Science literature databases. Of 593 studies potentially eligible, 41 were assessed in full-text, and nine studies were included in the systematic review and synthesis without meta-analysis following the SWiM guidelines. The included studies were highly heterogenous with respect to the type of interventions implemented and the outcomes measured. We identified that diet and physical activity interventions, surgical weight loss interventions, and hormonal interventions were associated with changes in endometrial cancer biomarkers including circulating hormones and tissue markers. We identified a reduction in endometrial proliferation following lifestyle intervention as measured by the ki-67 proliferation index. Furthermore we identified an increase in adiponectin (a circulating biomarker of adiposity) following lifestyle intervention and a reduction in circulating insulin levels following lifestyle intervention. This review highlighted that the area of endometrial cancer prevention research is in its infancy and that further investigation of diet and physical activity interventions, surgical weight loss interventions, and hormonal interventions should be undertaken due to promising preliminary evidence. |
| first_indexed | 2024-04-13T15:47:22Z |
| format | Article |
| id | doaj.art-49896688f3664ea69c130282cc5aafa6 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-04-13T15:47:22Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-49896688f3664ea69c130282cc5aafa62022-12-22T02:40:56ZengElsevierGynecologic Oncology Reports2352-57892022-02-0139100900Prevention of endometrial cancer through lifestyle Interventions: A systematic review and synthesisDayle Rundle-Thiele0Sujal Shrestha1Monika Janda2Department of Obstetrics and Gynaecology, Gold Coast University Hospital, Gold Coast, Queensland, Australia; Corresponding author at: Department of Obstetrics and Gynaecology, Gold Coast University Hospital, 1 Hospital Blvd, Southport, QLD 4218, Australia.School of Medicine, The University of Queensland, Brisbane, Queensland, AustraliaCentre of Health Services Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, AustraliaEndometrial cancer is the most common gynaecological malignancy in Australia. Epidemiological studies have widely documented the association of endometrial cancer with modifiable lifestyle risk factors, most notably obesity. However, preventative strategies for endometrial cancer have not been well reported. The objective of this systematic review was to identify interventions targeted towards modifiable lifestyle risk factors that may reduce the risk of endometrial cancer. Literature published in the past ten years (January 2010 – January 2021) was retrieved from PubMed, Embase and Web of Science literature databases. Of 593 studies potentially eligible, 41 were assessed in full-text, and nine studies were included in the systematic review and synthesis without meta-analysis following the SWiM guidelines. The included studies were highly heterogenous with respect to the type of interventions implemented and the outcomes measured. We identified that diet and physical activity interventions, surgical weight loss interventions, and hormonal interventions were associated with changes in endometrial cancer biomarkers including circulating hormones and tissue markers. We identified a reduction in endometrial proliferation following lifestyle intervention as measured by the ki-67 proliferation index. Furthermore we identified an increase in adiponectin (a circulating biomarker of adiposity) following lifestyle intervention and a reduction in circulating insulin levels following lifestyle intervention. This review highlighted that the area of endometrial cancer prevention research is in its infancy and that further investigation of diet and physical activity interventions, surgical weight loss interventions, and hormonal interventions should be undertaken due to promising preliminary evidence.http://www.sciencedirect.com/science/article/pii/S2352578921002046Endometrial cancerLifestyleLifestyle interventionPrevention |
| spellingShingle | Dayle Rundle-Thiele Sujal Shrestha Monika Janda Prevention of endometrial cancer through lifestyle Interventions: A systematic review and synthesis Gynecologic Oncology Reports Endometrial cancer Lifestyle Lifestyle intervention Prevention |
| title | Prevention of endometrial cancer through lifestyle Interventions: A systematic review and synthesis |
| title_full | Prevention of endometrial cancer through lifestyle Interventions: A systematic review and synthesis |
| title_fullStr | Prevention of endometrial cancer through lifestyle Interventions: A systematic review and synthesis |
| title_full_unstemmed | Prevention of endometrial cancer through lifestyle Interventions: A systematic review and synthesis |
| title_short | Prevention of endometrial cancer through lifestyle Interventions: A systematic review and synthesis |
| title_sort | prevention of endometrial cancer through lifestyle interventions a systematic review and synthesis |
| topic | Endometrial cancer Lifestyle Lifestyle intervention Prevention |
| url | http://www.sciencedirect.com/science/article/pii/S2352578921002046 |
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