Immune Phenotype as a Biomarker for Systemic Lupus Erythematosus
The treatment of rheumatoid arthritis was revolutionized with the use of molecular-targeted drugs that target immunoregulatory molecules. The success of treatment with these drugs prompted the development of molecular-targeted drugs for systemic lupus erythematosus. However, systemic lupus erythemat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/6/960 |
| _version_ | 1797595803802402816 |
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| author | Shingo Nakayamada Yoshiya Tanaka |
| author_facet | Shingo Nakayamada Yoshiya Tanaka |
| author_sort | Shingo Nakayamada |
| collection | DOAJ |
| description | The treatment of rheumatoid arthritis was revolutionized with the use of molecular-targeted drugs that target immunoregulatory molecules. The success of treatment with these drugs prompted the development of molecular-targeted drugs for systemic lupus erythematosus. However, systemic lupus erythematosus is a disease with high heterogeneous immune abnormalities, and diverse cells or molecules can be treatment targets. Thus, the identification of subpopulations based on immune abnormalities is essential for the development of effective treatment. One analytical method used to identify subpopulations is the immunophenotyping of peripheral blood samples of patients. This analysis evaluates the validity of target molecules for peripheral blood immune cell subsets, which are expected to be developed as biomarkers for precision medicine in which appropriate treatment targets are set for each subpopulation. |
| first_indexed | 2024-03-11T02:41:39Z |
| format | Article |
| id | doaj.art-4989bc833940431b8c2c4efc62b06b23 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T02:41:39Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-4989bc833940431b8c2c4efc62b06b232023-11-18T09:31:13ZengMDPI AGBiomolecules2218-273X2023-06-0113696010.3390/biom13060960Immune Phenotype as a Biomarker for Systemic Lupus ErythematosusShingo Nakayamada0Yoshiya Tanaka1The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807-8555, Fukuoka, JapanThe First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807-8555, Fukuoka, JapanThe treatment of rheumatoid arthritis was revolutionized with the use of molecular-targeted drugs that target immunoregulatory molecules. The success of treatment with these drugs prompted the development of molecular-targeted drugs for systemic lupus erythematosus. However, systemic lupus erythematosus is a disease with high heterogeneous immune abnormalities, and diverse cells or molecules can be treatment targets. Thus, the identification of subpopulations based on immune abnormalities is essential for the development of effective treatment. One analytical method used to identify subpopulations is the immunophenotyping of peripheral blood samples of patients. This analysis evaluates the validity of target molecules for peripheral blood immune cell subsets, which are expected to be developed as biomarkers for precision medicine in which appropriate treatment targets are set for each subpopulation.https://www.mdpi.com/2218-273X/13/6/960systemic lupus erythematosusprecision medicinebiomarkersimmunophenotyping |
| spellingShingle | Shingo Nakayamada Yoshiya Tanaka Immune Phenotype as a Biomarker for Systemic Lupus Erythematosus Biomolecules systemic lupus erythematosus precision medicine biomarkers immunophenotyping |
| title | Immune Phenotype as a Biomarker for Systemic Lupus Erythematosus |
| title_full | Immune Phenotype as a Biomarker for Systemic Lupus Erythematosus |
| title_fullStr | Immune Phenotype as a Biomarker for Systemic Lupus Erythematosus |
| title_full_unstemmed | Immune Phenotype as a Biomarker for Systemic Lupus Erythematosus |
| title_short | Immune Phenotype as a Biomarker for Systemic Lupus Erythematosus |
| title_sort | immune phenotype as a biomarker for systemic lupus erythematosus |
| topic | systemic lupus erythematosus precision medicine biomarkers immunophenotyping |
| url | https://www.mdpi.com/2218-273X/13/6/960 |
| work_keys_str_mv | AT shingonakayamada immunephenotypeasabiomarkerforsystemiclupuserythematosus AT yoshiyatanaka immunephenotypeasabiomarkerforsystemiclupuserythematosus |