Fluid flow to mimic organ function in 3D in vitro models
Many different strategies can be found in the literature to model organ physiology, tissue functionality, and disease in vitro; however, most of these models lack the physiological fluid dynamics present in vivo. Here, we highlight the importance of fluid flow for tissue homeostasis, specifically in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2023-09-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/5.0146000 |
| _version_ | 1797663126583246848 |
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| author | Yago Juste-Lanas Silvia Hervas-Raluy José Manuel García-Aznar Alejandra González-Loyola |
| author_facet | Yago Juste-Lanas Silvia Hervas-Raluy José Manuel García-Aznar Alejandra González-Loyola |
| author_sort | Yago Juste-Lanas |
| collection | DOAJ |
| description | Many different strategies can be found in the literature to model organ physiology, tissue functionality, and disease in vitro; however, most of these models lack the physiological fluid dynamics present in vivo. Here, we highlight the importance of fluid flow for tissue homeostasis, specifically in vessels, other lumen structures, and interstitium, to point out the need of perfusion in current 3D in vitro models. Importantly, the advantages and limitations of the different current experimental fluid-flow setups are discussed. Finally, we shed light on current challenges and future focus of fluid flow models applied to the newest bioengineering state-of-the-art platforms, such as organoids and organ-on-a-chip, as the most sophisticated and physiological preclinical platforms. |
| first_indexed | 2024-03-11T19:10:05Z |
| format | Article |
| id | doaj.art-4989efd441f349db8a01e947a0a773b4 |
| institution | Directory Open Access Journal |
| issn | 2473-2877 |
| language | English |
| last_indexed | 2024-03-11T19:10:05Z |
| publishDate | 2023-09-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Bioengineering |
| spelling | doaj.art-4989efd441f349db8a01e947a0a773b42023-10-09T20:09:13ZengAIP Publishing LLCAPL Bioengineering2473-28772023-09-0173031501031501-2410.1063/5.0146000Fluid flow to mimic organ function in 3D in vitro modelsYago Juste-Lanas0Silvia Hervas-Raluy1José Manuel García-Aznar2Alejandra González-Loyola3 Department of Mechanical Engineering, Engineering Research Institute of Aragón (I3A), University of Zaragoza, Zaragoza, Spain Department of Mechanical Engineering, Engineering Research Institute of Aragón (I3A), University of Zaragoza, Zaragoza, Spain Department of Mechanical Engineering, Engineering Research Institute of Aragón (I3A), University of Zaragoza, Zaragoza, Spain Department of Mechanical Engineering, Engineering Research Institute of Aragón (I3A), University of Zaragoza, Zaragoza, SpainMany different strategies can be found in the literature to model organ physiology, tissue functionality, and disease in vitro; however, most of these models lack the physiological fluid dynamics present in vivo. Here, we highlight the importance of fluid flow for tissue homeostasis, specifically in vessels, other lumen structures, and interstitium, to point out the need of perfusion in current 3D in vitro models. Importantly, the advantages and limitations of the different current experimental fluid-flow setups are discussed. Finally, we shed light on current challenges and future focus of fluid flow models applied to the newest bioengineering state-of-the-art platforms, such as organoids and organ-on-a-chip, as the most sophisticated and physiological preclinical platforms.http://dx.doi.org/10.1063/5.0146000 |
| spellingShingle | Yago Juste-Lanas Silvia Hervas-Raluy José Manuel García-Aznar Alejandra González-Loyola Fluid flow to mimic organ function in 3D in vitro models APL Bioengineering |
| title | Fluid flow to mimic organ function in 3D in vitro models |
| title_full | Fluid flow to mimic organ function in 3D in vitro models |
| title_fullStr | Fluid flow to mimic organ function in 3D in vitro models |
| title_full_unstemmed | Fluid flow to mimic organ function in 3D in vitro models |
| title_short | Fluid flow to mimic organ function in 3D in vitro models |
| title_sort | fluid flow to mimic organ function in 3d in vitro models |
| url | http://dx.doi.org/10.1063/5.0146000 |
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