Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors

Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors

Depression is a chronic and recurrent disorder, associated with high morbidity and risk of suicide. Leptin was firstly described as an anti-obesity hormone, but several actions of leptin in CNS have been reported. In fact, leptin regulates dopaminergic neurotransmission in mesolimbic areas and has a...

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Bibliographic Details
Main Authors: Rafaela Carneiro Cordeiro, Adriano José Maia Chaves Filho, Nayana Soares Gomes, Viviane de Sousa Tomaz, Camila Dantas Medeiros, Ana Isabelle de Góis Queiroz, Michael Maes, Danielle S. Macedo, Andre F. Carvalho
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Psychiatry
Subjects:
leptin
depression
LPS
dopamine
prefrontal cortex
psychiatry
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00125/full

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