MicroRNAs in Cancer and Cardiovascular Disease
Although cardiac tumor formation is rare, accumulating evidence suggests that the two leading causes of deaths, cancers, and cardiovascular diseases are similar in terms of pathogenesis, including angiogenesis, immune responses, and fibrosis. These similarities have led to the creation of new exciti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/22/3551 |
| _version_ | 1827644784539336704 |
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| author | Mirolyuba Ilieva Riccardo Panella Shizuka Uchida |
| author_facet | Mirolyuba Ilieva Riccardo Panella Shizuka Uchida |
| author_sort | Mirolyuba Ilieva |
| collection | DOAJ |
| description | Although cardiac tumor formation is rare, accumulating evidence suggests that the two leading causes of deaths, cancers, and cardiovascular diseases are similar in terms of pathogenesis, including angiogenesis, immune responses, and fibrosis. These similarities have led to the creation of new exciting field of study called cardio-oncology. Here, we review the similarities between cancer and cardiovascular disease from the perspective of microRNAs (miRNAs). As miRNAs are well-known regulators of translation by binding to the 3′-untranslated regions (UTRs) of messenger RNAs (mRNAs), we carefully dissect how a specific set of miRNAs are both oncomiRs (miRNAs in cancer) and myomiRs (muscle-related miRNAs). Furthermore, from the standpoint of similar pathogenesis, miRNAs categories related to the similar pathogenesis are discussed; namely, angiomiRs, Immune-miRs, and fibromiRs. |
| first_indexed | 2024-03-09T18:25:17Z |
| format | Article |
| id | doaj.art-498b2b5ee67942c8a4aafaf52781b672 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T18:25:17Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-498b2b5ee67942c8a4aafaf52781b6722023-11-24T07:57:16ZengMDPI AGCells2073-44092022-11-011122355110.3390/cells11223551MicroRNAs in Cancer and Cardiovascular DiseaseMirolyuba Ilieva0Riccardo Panella1Shizuka Uchida2Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen SV, DenmarkCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen SV, DenmarkCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen SV, DenmarkAlthough cardiac tumor formation is rare, accumulating evidence suggests that the two leading causes of deaths, cancers, and cardiovascular diseases are similar in terms of pathogenesis, including angiogenesis, immune responses, and fibrosis. These similarities have led to the creation of new exciting field of study called cardio-oncology. Here, we review the similarities between cancer and cardiovascular disease from the perspective of microRNAs (miRNAs). As miRNAs are well-known regulators of translation by binding to the 3′-untranslated regions (UTRs) of messenger RNAs (mRNAs), we carefully dissect how a specific set of miRNAs are both oncomiRs (miRNAs in cancer) and myomiRs (muscle-related miRNAs). Furthermore, from the standpoint of similar pathogenesis, miRNAs categories related to the similar pathogenesis are discussed; namely, angiomiRs, Immune-miRs, and fibromiRs.https://www.mdpi.com/2073-4409/11/22/3551cancercardiovascular diseasemiRNA |
| spellingShingle | Mirolyuba Ilieva Riccardo Panella Shizuka Uchida MicroRNAs in Cancer and Cardiovascular Disease Cells cancer cardiovascular disease miRNA |
| title | MicroRNAs in Cancer and Cardiovascular Disease |
| title_full | MicroRNAs in Cancer and Cardiovascular Disease |
| title_fullStr | MicroRNAs in Cancer and Cardiovascular Disease |
| title_full_unstemmed | MicroRNAs in Cancer and Cardiovascular Disease |
| title_short | MicroRNAs in Cancer and Cardiovascular Disease |
| title_sort | micrornas in cancer and cardiovascular disease |
| topic | cancer cardiovascular disease miRNA |
| url | https://www.mdpi.com/2073-4409/11/22/3551 |
| work_keys_str_mv | AT mirolyubailieva micrornasincancerandcardiovasculardisease AT riccardopanella micrornasincancerandcardiovasculardisease AT shizukauchida micrornasincancerandcardiovasculardisease |