Timing of introduction to solid food, eczema and wheezing in later childhood: a longitudinal cohort study
Abstract Background The timing of introduction to solid food has been associated with eczema and wheezing in childhood. Our aim was to determine whether differences persist within the recommended 4 to 6 month age range. Methods A longitudinal cohort study with repeated measures was conducted among c...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-023-04262-0 |
| _version_ | 1797556363061100544 |
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| author | Curtis J. D’Hollander Charles D. G. Keown-Stoneman Catherine S. Birken Deborah L. O’Connor Jonathon L. Maguire TARGet Kids! collaboration |
| author_facet | Curtis J. D’Hollander Charles D. G. Keown-Stoneman Catherine S. Birken Deborah L. O’Connor Jonathon L. Maguire TARGet Kids! collaboration |
| author_sort | Curtis J. D’Hollander |
| collection | DOAJ |
| description | Abstract Background The timing of introduction to solid food has been associated with eczema and wheezing in childhood. Our aim was to determine whether differences persist within the recommended 4 to 6 month age range. Methods A longitudinal cohort study with repeated measures was conducted among children from birth to 10 years of age who were participating in the TARGet Kids! practice based research network in Toronto, Canada. The primary exposure was the timing of introduction to infant cereal as the first solid food. The primary outcome was eczema and the secondary outcome was wheezing collected by parent report using the validated International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Multinomial generalized estimating equations were used and effect modification by family history of asthma and breastfeeding duration were explored. Results Of the 7843 children included, the mean (standard deviation) age of introduction to infant cereal was 5.7 (1.9) months. There was evidence for family history of asthma and breastfeeding duration to be effect modifiers in the eczema (P = 0.04) and wheezing (P = 0.05) models. Introduction to infant cereal at 4 vs. 6 months of age was associated with higher odds of eczema (OR 1.62; 95% CI: 1.12, 2.35; P = 0.01) among children without a family history of asthma who were not breastfeeding when solid foods were introduced. Introduction to infant cereal at 4 vs. 6 months of age was associated with a higher odds of wheezing (OR 1.31; 95% CI: 1.13, 1.52; P < .001) among children without a family history of asthma who were breastfeeding when solid foods were introduced. There was little evidence of an association among the remaining strata for either outcome. Conclusion The findings of this study support recommendations to introduce solid food around 6 months of age. |
| first_indexed | 2024-03-10T17:01:47Z |
| format | Article |
| id | doaj.art-498b3c2072b74ea39cf42568627dff8c |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-03-10T17:01:47Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-498b3c2072b74ea39cf42568627dff8c2023-11-20T10:56:56ZengBMCBMC Pediatrics1471-24312023-10-0123111010.1186/s12887-023-04262-0Timing of introduction to solid food, eczema and wheezing in later childhood: a longitudinal cohort studyCurtis J. D’Hollander0Charles D. G. Keown-Stoneman1Catherine S. Birken2Deborah L. O’Connor3Jonathon L. Maguire4TARGet Kids! collaborationDepartment of Nutritional Sciences, University of TorontoApplied Health Research Centre, Unity Health TorontoDivision of Pediatric Medicine, Hospital for Sick ChildrenDepartment of Nutritional Sciences, University of TorontoDepartment of Pediatrics, St Michael’s HospitalAbstract Background The timing of introduction to solid food has been associated with eczema and wheezing in childhood. Our aim was to determine whether differences persist within the recommended 4 to 6 month age range. Methods A longitudinal cohort study with repeated measures was conducted among children from birth to 10 years of age who were participating in the TARGet Kids! practice based research network in Toronto, Canada. The primary exposure was the timing of introduction to infant cereal as the first solid food. The primary outcome was eczema and the secondary outcome was wheezing collected by parent report using the validated International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Multinomial generalized estimating equations were used and effect modification by family history of asthma and breastfeeding duration were explored. Results Of the 7843 children included, the mean (standard deviation) age of introduction to infant cereal was 5.7 (1.9) months. There was evidence for family history of asthma and breastfeeding duration to be effect modifiers in the eczema (P = 0.04) and wheezing (P = 0.05) models. Introduction to infant cereal at 4 vs. 6 months of age was associated with higher odds of eczema (OR 1.62; 95% CI: 1.12, 2.35; P = 0.01) among children without a family history of asthma who were not breastfeeding when solid foods were introduced. Introduction to infant cereal at 4 vs. 6 months of age was associated with a higher odds of wheezing (OR 1.31; 95% CI: 1.13, 1.52; P < .001) among children without a family history of asthma who were breastfeeding when solid foods were introduced. There was little evidence of an association among the remaining strata for either outcome. Conclusion The findings of this study support recommendations to introduce solid food around 6 months of age.https://doi.org/10.1186/s12887-023-04262-0Timing of introduction to solid foodAtopic diseaseAllergyAtopic dermatitisWheezeBreastfeeding |
| spellingShingle | Curtis J. D’Hollander Charles D. G. Keown-Stoneman Catherine S. Birken Deborah L. O’Connor Jonathon L. Maguire TARGet Kids! collaboration Timing of introduction to solid food, eczema and wheezing in later childhood: a longitudinal cohort study BMC Pediatrics Timing of introduction to solid food Atopic disease Allergy Atopic dermatitis Wheeze Breastfeeding |
| title | Timing of introduction to solid food, eczema and wheezing in later childhood: a longitudinal cohort study |
| title_full | Timing of introduction to solid food, eczema and wheezing in later childhood: a longitudinal cohort study |
| title_fullStr | Timing of introduction to solid food, eczema and wheezing in later childhood: a longitudinal cohort study |
| title_full_unstemmed | Timing of introduction to solid food, eczema and wheezing in later childhood: a longitudinal cohort study |
| title_short | Timing of introduction to solid food, eczema and wheezing in later childhood: a longitudinal cohort study |
| title_sort | timing of introduction to solid food eczema and wheezing in later childhood a longitudinal cohort study |
| topic | Timing of introduction to solid food Atopic disease Allergy Atopic dermatitis Wheeze Breastfeeding |
| url | https://doi.org/10.1186/s12887-023-04262-0 |
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