A Staphylococcus aureus Coinfection on a COVID-19 Pneumonia in a Breast Cancer Patient
Silvia Spoto,1 Emanuele Valeriani,1 Elisabetta Riva,2 Marina De Cesaris,3 Giuseppe Tonini,4 Bruno Vincenzi,5 Luciana Locorriere,1 Giuseppina Beretta Anguissola,1 Angelo Lauria Pantano,1 Elisa Brando,1 Sebastiano Costantino,1 Massimo Ciccozzi,5 Silvia Angeletti3 1Diagnostic and Therapeutic Medicine D...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-09-01
|
| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-staphylococcus-aureus-coinfection-on-a-covid-19-pneumonia-in-a-breas-peer-reviewed-article-IJGM |
| _version_ | 1818406048939114496 |
|---|---|
| author | Spoto S Valeriani E Riva E De Cesaris M Tonini G Vincenzi B Locorriere L Beretta Anguissola G Lauria Pantano A Brando E Costantino S Ciccozzi M Angeletti S |
| author_facet | Spoto S Valeriani E Riva E De Cesaris M Tonini G Vincenzi B Locorriere L Beretta Anguissola G Lauria Pantano A Brando E Costantino S Ciccozzi M Angeletti S |
| author_sort | Spoto S |
| collection | DOAJ |
| description | Silvia Spoto,1 Emanuele Valeriani,1 Elisabetta Riva,2 Marina De Cesaris,3 Giuseppe Tonini,4 Bruno Vincenzi,5 Luciana Locorriere,1 Giuseppina Beretta Anguissola,1 Angelo Lauria Pantano,1 Elisa Brando,1 Sebastiano Costantino,1 Massimo Ciccozzi,5 Silvia Angeletti3 1Diagnostic and Therapeutic Medicine Department, University Campus Bio-Medico of Rome, Rome, Italy; 2Unit of Virology, University Campus Bio-Medico of Rome, Rome, Italy; 3Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy; 4Department of Medical Oncology, University Campus Bio-Medico of Rome, Rome, Italy; 5Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, ItalyCorrespondence: Silvia SpotoDiagnostic and Therapeutic Medicine Department, University Campus Bio-Medico of Rome, Rome, ItalyTel +3906225411461Email s.spoto@unicampus.itIntroduction: Coronavirus disease 19 (COVID-19), due to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2), comprises a broad spectrum of clinical presentation ranging from flu-like syndrome to organ failure. The risk of coinfections is high and responsible for a worse prognosis, mainly in the case of bacterial involvement and in the presence of particular comorbidity. We present the clinical, laboratory, radiologic characteristic along with therapeutic management of a patient with COVID-19 and Staphylococcus aureus coinfection.Case Presentation: A 55-year-old Caucasian woman was admitted to our hospital due to a two-day history of fever and acute dyspnea with severe respiratory failure worsened after the administration of atezolizumab and nab-paclitaxel. Her medical history comprehended a triple negative, BRCA1-related, PD-L1 positive right breast cancer with multiple bone metastasis, causing bone marrow infiltration-related severe pancytopenia. Her physical examination revealed scattered wheezes, rales, and bilateral dry crackles in the middle and lower lung fields and lower limb paresis. The body mass index was 30 kg/m2 and arterial blood gas evaluation revealed a stage III acute respiratory distress syndrome. Microbiological specimens revealed a Staphylococcus aureus positivity from endotracheal aspirate. The chest computed tomography (CT) scan showed the presence of large areas of parenchymal consolidation and aerial bronchogram, bilateral “ground glass” areas reaching the highest extension on the upper and middle zones. The high clinical and radiological suspicion of COVID-19 along with the negative result of nasopharyngeal specimen make necessary an endotracheal aspirate resulting positive for SARS-CoV2. Patient started an antimicrobial treatment and lopinavir-ritonavir plus hydroxychloroquine but, unfortunately, died five days after hospital admission.Conclusion: The high risk of mortality of our patient was due to viral-bacterial coinfection, advanced cancer status with active immunotherapy. This case highlights the need for a prompt clinical, laboratory, and radiological evaluation to allow a correct diagnosis and start a specific therapy.Keywords: COVID-19, SARS-CoV2, pneumonia, computed tomography, Staphylococcus aureus, cancer patient |
| first_indexed | 2024-12-14T09:05:45Z |
| format | Article |
| id | doaj.art-498bf3872f4f4425b371b2c49365cfde |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-14T09:05:45Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-498bf3872f4f4425b371b2c49365cfde2022-12-21T23:08:43ZengDove Medical PressInternational Journal of General Medicine1178-70742020-09-01Volume 1372973357575A Staphylococcus aureus Coinfection on a COVID-19 Pneumonia in a Breast Cancer PatientSpoto SValeriani ERiva EDe Cesaris MTonini GVincenzi BLocorriere LBeretta Anguissola GLauria Pantano ABrando ECostantino SCiccozzi MAngeletti SSilvia Spoto,1 Emanuele Valeriani,1 Elisabetta Riva,2 Marina De Cesaris,3 Giuseppe Tonini,4 Bruno Vincenzi,5 Luciana Locorriere,1 Giuseppina Beretta Anguissola,1 Angelo Lauria Pantano,1 Elisa Brando,1 Sebastiano Costantino,1 Massimo Ciccozzi,5 Silvia Angeletti3 1Diagnostic and Therapeutic Medicine Department, University Campus Bio-Medico of Rome, Rome, Italy; 2Unit of Virology, University Campus Bio-Medico of Rome, Rome, Italy; 3Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy; 4Department of Medical Oncology, University Campus Bio-Medico of Rome, Rome, Italy; 5Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, ItalyCorrespondence: Silvia SpotoDiagnostic and Therapeutic Medicine Department, University Campus Bio-Medico of Rome, Rome, ItalyTel +3906225411461Email s.spoto@unicampus.itIntroduction: Coronavirus disease 19 (COVID-19), due to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2), comprises a broad spectrum of clinical presentation ranging from flu-like syndrome to organ failure. The risk of coinfections is high and responsible for a worse prognosis, mainly in the case of bacterial involvement and in the presence of particular comorbidity. We present the clinical, laboratory, radiologic characteristic along with therapeutic management of a patient with COVID-19 and Staphylococcus aureus coinfection.Case Presentation: A 55-year-old Caucasian woman was admitted to our hospital due to a two-day history of fever and acute dyspnea with severe respiratory failure worsened after the administration of atezolizumab and nab-paclitaxel. Her medical history comprehended a triple negative, BRCA1-related, PD-L1 positive right breast cancer with multiple bone metastasis, causing bone marrow infiltration-related severe pancytopenia. Her physical examination revealed scattered wheezes, rales, and bilateral dry crackles in the middle and lower lung fields and lower limb paresis. The body mass index was 30 kg/m2 and arterial blood gas evaluation revealed a stage III acute respiratory distress syndrome. Microbiological specimens revealed a Staphylococcus aureus positivity from endotracheal aspirate. The chest computed tomography (CT) scan showed the presence of large areas of parenchymal consolidation and aerial bronchogram, bilateral “ground glass” areas reaching the highest extension on the upper and middle zones. The high clinical and radiological suspicion of COVID-19 along with the negative result of nasopharyngeal specimen make necessary an endotracheal aspirate resulting positive for SARS-CoV2. Patient started an antimicrobial treatment and lopinavir-ritonavir plus hydroxychloroquine but, unfortunately, died five days after hospital admission.Conclusion: The high risk of mortality of our patient was due to viral-bacterial coinfection, advanced cancer status with active immunotherapy. This case highlights the need for a prompt clinical, laboratory, and radiological evaluation to allow a correct diagnosis and start a specific therapy.Keywords: COVID-19, SARS-CoV2, pneumonia, computed tomography, Staphylococcus aureus, cancer patienthttps://www.dovepress.com/a-staphylococcus-aureus-coinfection-on-a-covid-19-pneumonia-in-a-breas-peer-reviewed-article-IJGMcovid-19sars-cov2pneumoniacomputed tomographystaphylococcus aureuscancer patient |
| spellingShingle | Spoto S Valeriani E Riva E De Cesaris M Tonini G Vincenzi B Locorriere L Beretta Anguissola G Lauria Pantano A Brando E Costantino S Ciccozzi M Angeletti S A Staphylococcus aureus Coinfection on a COVID-19 Pneumonia in a Breast Cancer Patient International Journal of General Medicine covid-19 sars-cov2 pneumonia computed tomography staphylococcus aureus cancer patient |
| title | A Staphylococcus aureus Coinfection on a COVID-19 Pneumonia in a Breast Cancer Patient |
| title_full | A Staphylococcus aureus Coinfection on a COVID-19 Pneumonia in a Breast Cancer Patient |
| title_fullStr | A Staphylococcus aureus Coinfection on a COVID-19 Pneumonia in a Breast Cancer Patient |
| title_full_unstemmed | A Staphylococcus aureus Coinfection on a COVID-19 Pneumonia in a Breast Cancer Patient |
| title_short | A Staphylococcus aureus Coinfection on a COVID-19 Pneumonia in a Breast Cancer Patient |
| title_sort | staphylococcus aureus coinfection on a covid 19 pneumonia in a breast cancer patient |
| topic | covid-19 sars-cov2 pneumonia computed tomography staphylococcus aureus cancer patient |
| url | https://www.dovepress.com/a-staphylococcus-aureus-coinfection-on-a-covid-19-pneumonia-in-a-breas-peer-reviewed-article-IJGM |
| work_keys_str_mv | AT spotos astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT valerianie astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT rivae astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT decesarism astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT toninig astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT vincenzib astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT locorrierel astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT berettaanguissolag astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT lauriapantanoa astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT brandoe astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT costantinos astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT ciccozzim astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT angelettis astaphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT spotos staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT valerianie staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT rivae staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT decesarism staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT toninig staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT vincenzib staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT locorrierel staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT berettaanguissolag staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT lauriapantanoa staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT brandoe staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT costantinos staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT ciccozzim staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient AT angelettis staphylococcusaureuscoinfectiononacovid19pneumoniainabreastcancerpatient |