Development and validation of a scatter-corrected CBCT image-guided method for cervical cancer brachytherapy
Background and purposeMultiple patient transfers have a nonnegligible impact on the accuracy of dose delivery for cervical cancer brachytherapy. We consider using on-site cone-beam CT (CBCT) to resolve this problem. However, CBCT clinical applications are limited due to inadequate image quality. Thi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.942016/full |
| _version_ | 1797989493969518592 |
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| author | Ailin Wu Hehe Cui Xiao Jiang Bing Yan Aidong Wu Yunqin Liu Lei Zhu |
| author_facet | Ailin Wu Hehe Cui Xiao Jiang Bing Yan Aidong Wu Yunqin Liu Lei Zhu |
| author_sort | Ailin Wu |
| collection | DOAJ |
| description | Background and purposeMultiple patient transfers have a nonnegligible impact on the accuracy of dose delivery for cervical cancer brachytherapy. We consider using on-site cone-beam CT (CBCT) to resolve this problem. However, CBCT clinical applications are limited due to inadequate image quality. This paper implements a scatter correction method using planning CT (pCT) prior to obtaining high-quality CBCT images and evaluates the dose calculation accuracy of CBCT-guided brachytherapy for cervical cancer.Materials and methodsThe CBCT of a self-developed female pelvis phantom and five patients was first corrected using empirical uniform scatter correction in the projection domain and further corrected in the image domain. In both phantom and patient studies, the CBCT image quality before and after scatter correction was evaluated with registered pCT (rCT). Model-based dose calculation was performed using the commercial package Acuros®BV. The dose distributions of rCT-based plans and corrected CBCT-based plans in the phantom and patients were compared using 3D local gamma analysis. A statistical analysis of the differences in dosimetric parameters of five patients was also performed.ResultsIn both phantom and patient studies, the HU error of selected ROIs was reduced to less than 15 HU. Using the dose distribution of the rCT-based plan as the baseline, the γ pass rate (2%, 2 mm) of the corrected CBCT-based plan in phantom and patients all exceeded 98% and 93%, respectively, with the threshold dose set to 3, 6, 9, and 12 Gy. The average percentage deviation (APD) of D90 of HRCTV and D2cc of OARs was less than 1% between rCT-based and corrected CBCT-based plans.ConclusionScatter correction using a pCT prior can effectively improve the CBCT image quality and CBCT-based cervical brachytherapy dose calculation accuracy, indicating promising prospects in both simplified brachytherapy processes and accurate brachytherapy dose delivery. |
| first_indexed | 2024-04-11T08:21:14Z |
| format | Article |
| id | doaj.art-498db8b8c94a4ed3b4c9985079dd8fea |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T08:21:14Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-498db8b8c94a4ed3b4c9985079dd8fea2022-12-22T04:34:57ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.942016942016Development and validation of a scatter-corrected CBCT image-guided method for cervical cancer brachytherapyAilin Wu0Hehe Cui1Xiao Jiang2Bing Yan3Aidong Wu4Yunqin Liu5Lei Zhu6Department of Radiation Oncology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Engineering and Applied Physics, University of Science and Technology of China, Hefei, ChinaDepartment of Engineering and Applied Physics, University of Science and Technology of China, Hefei, ChinaDepartment of Radiation Oncology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Radiation Oncology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Radiation Oncology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Engineering and Applied Physics, University of Science and Technology of China, Hefei, ChinaBackground and purposeMultiple patient transfers have a nonnegligible impact on the accuracy of dose delivery for cervical cancer brachytherapy. We consider using on-site cone-beam CT (CBCT) to resolve this problem. However, CBCT clinical applications are limited due to inadequate image quality. This paper implements a scatter correction method using planning CT (pCT) prior to obtaining high-quality CBCT images and evaluates the dose calculation accuracy of CBCT-guided brachytherapy for cervical cancer.Materials and methodsThe CBCT of a self-developed female pelvis phantom and five patients was first corrected using empirical uniform scatter correction in the projection domain and further corrected in the image domain. In both phantom and patient studies, the CBCT image quality before and after scatter correction was evaluated with registered pCT (rCT). Model-based dose calculation was performed using the commercial package Acuros®BV. The dose distributions of rCT-based plans and corrected CBCT-based plans in the phantom and patients were compared using 3D local gamma analysis. A statistical analysis of the differences in dosimetric parameters of five patients was also performed.ResultsIn both phantom and patient studies, the HU error of selected ROIs was reduced to less than 15 HU. Using the dose distribution of the rCT-based plan as the baseline, the γ pass rate (2%, 2 mm) of the corrected CBCT-based plan in phantom and patients all exceeded 98% and 93%, respectively, with the threshold dose set to 3, 6, 9, and 12 Gy. The average percentage deviation (APD) of D90 of HRCTV and D2cc of OARs was less than 1% between rCT-based and corrected CBCT-based plans.ConclusionScatter correction using a pCT prior can effectively improve the CBCT image quality and CBCT-based cervical brachytherapy dose calculation accuracy, indicating promising prospects in both simplified brachytherapy processes and accurate brachytherapy dose delivery.https://www.frontiersin.org/articles/10.3389/fonc.2022.942016/fullcervical cancerCBCTscatter correctionmodel-based dose calculation algorithmbrachytherapy |
| spellingShingle | Ailin Wu Hehe Cui Xiao Jiang Bing Yan Aidong Wu Yunqin Liu Lei Zhu Development and validation of a scatter-corrected CBCT image-guided method for cervical cancer brachytherapy Frontiers in Oncology cervical cancer CBCT scatter correction model-based dose calculation algorithm brachytherapy |
| title | Development and validation of a scatter-corrected CBCT image-guided method for cervical cancer brachytherapy |
| title_full | Development and validation of a scatter-corrected CBCT image-guided method for cervical cancer brachytherapy |
| title_fullStr | Development and validation of a scatter-corrected CBCT image-guided method for cervical cancer brachytherapy |
| title_full_unstemmed | Development and validation of a scatter-corrected CBCT image-guided method for cervical cancer brachytherapy |
| title_short | Development and validation of a scatter-corrected CBCT image-guided method for cervical cancer brachytherapy |
| title_sort | development and validation of a scatter corrected cbct image guided method for cervical cancer brachytherapy |
| topic | cervical cancer CBCT scatter correction model-based dose calculation algorithm brachytherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.942016/full |
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