Case Report: A case of multisystem inflammatory syndrome in an 11-year-old female after COVID-19 inactivated vaccine
BackgroundMultisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory, multisystem syndrome temporally associated with SARS-CoV-2, is a rare but serious complication of SARS-CoV-2 infection in children that typically occurs 2–6 weeks after SARS-CoV-2 infection. The pa...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1068301/full |
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| author | Saboor Saeed Saboor Saeed Jianqing Cao Jinjiao Xu Yi Zhang Xuyang Zheng Liya Jiang Chunming Jiang Chunming Jiang Xinjuan Zhang Xinjuan Zhang |
| author_facet | Saboor Saeed Saboor Saeed Jianqing Cao Jinjiao Xu Yi Zhang Xuyang Zheng Liya Jiang Chunming Jiang Chunming Jiang Xinjuan Zhang Xinjuan Zhang |
| author_sort | Saboor Saeed |
| collection | DOAJ |
| description | BackgroundMultisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory, multisystem syndrome temporally associated with SARS-CoV-2, is a rare but serious complication of SARS-CoV-2 infection in children that typically occurs 2–6 weeks after SARS-CoV-2 infection. The pathophysiology of MIS-C is unknown. MIS-C, first recognized in April 2020, is characterized by fever, systemic inflammation, and multi-system organ involvement. Post-vaccination adverse effects have increased with COVID-19 vaccinations, and MIS linked to immunization with COVID-19 vaccines has also been observed.Case ReportAn 11-year-old Chinese girl presented with a high-grade fever, rash, and dry cough for 2 days. She had her 2nd SARS-CoV-2 inactivated vaccination dose five days before hospital admission. On day 3 & 4, she experienced bilateral conjunctivitis, hypotension (66/47 mmHg), and a high CRP level. She was diagnosed with MIS-C. The patient's condition deteriorated rapidly, necessitating intensive care unit admission. The patient's symptoms improved after intravenous immunoglobulin, methylprednisolone, and oral aspirin therapy. She was discharged from the hospital after 16 days as her general condition, and laboratory biomarkers returned to normal.ConclusionInactivated Covid-19 vaccination might trigger MIS-C. Further research is needed to evaluate whether a correlation exists between COVID-19 vaccination and MIS-C development. |
| first_indexed | 2024-04-10T15:17:05Z |
| format | Article |
| id | doaj.art-498e572ea5a24d7fba8f520f7381c394 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-10T15:17:05Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-498e572ea5a24d7fba8f520f7381c3942023-02-14T19:07:51ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-02-011110.3389/fped.2023.10683011068301Case Report: A case of multisystem inflammatory syndrome in an 11-year-old female after COVID-19 inactivated vaccineSaboor Saeed0Saboor Saeed1Jianqing Cao2Jinjiao Xu3Yi Zhang4Xuyang Zheng5Liya Jiang6Chunming Jiang7Chunming Jiang8Xinjuan Zhang9Xinjuan Zhang10Department of Pediatrics, International Education College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Pediatrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Pediatrics, The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Pediatrics, The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Pediatrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Pediatrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Pediatrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Pediatrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Pediatrics, The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Pediatrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Pediatrics, The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaBackgroundMultisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory, multisystem syndrome temporally associated with SARS-CoV-2, is a rare but serious complication of SARS-CoV-2 infection in children that typically occurs 2–6 weeks after SARS-CoV-2 infection. The pathophysiology of MIS-C is unknown. MIS-C, first recognized in April 2020, is characterized by fever, systemic inflammation, and multi-system organ involvement. Post-vaccination adverse effects have increased with COVID-19 vaccinations, and MIS linked to immunization with COVID-19 vaccines has also been observed.Case ReportAn 11-year-old Chinese girl presented with a high-grade fever, rash, and dry cough for 2 days. She had her 2nd SARS-CoV-2 inactivated vaccination dose five days before hospital admission. On day 3 & 4, she experienced bilateral conjunctivitis, hypotension (66/47 mmHg), and a high CRP level. She was diagnosed with MIS-C. The patient's condition deteriorated rapidly, necessitating intensive care unit admission. The patient's symptoms improved after intravenous immunoglobulin, methylprednisolone, and oral aspirin therapy. She was discharged from the hospital after 16 days as her general condition, and laboratory biomarkers returned to normal.ConclusionInactivated Covid-19 vaccination might trigger MIS-C. Further research is needed to evaluate whether a correlation exists between COVID-19 vaccination and MIS-C development.https://www.frontiersin.org/articles/10.3389/fped.2023.1068301/fullSARS-CoV2covid-19 inactivated vaccinemultisystem inflammatory syndromemethylprednisolonecoronavirus disease 2019 (COVID-19) |
| spellingShingle | Saboor Saeed Saboor Saeed Jianqing Cao Jinjiao Xu Yi Zhang Xuyang Zheng Liya Jiang Chunming Jiang Chunming Jiang Xinjuan Zhang Xinjuan Zhang Case Report: A case of multisystem inflammatory syndrome in an 11-year-old female after COVID-19 inactivated vaccine Frontiers in Pediatrics SARS-CoV2 covid-19 inactivated vaccine multisystem inflammatory syndrome methylprednisolone coronavirus disease 2019 (COVID-19) |
| title | Case Report: A case of multisystem inflammatory syndrome in an 11-year-old female after COVID-19 inactivated vaccine |
| title_full | Case Report: A case of multisystem inflammatory syndrome in an 11-year-old female after COVID-19 inactivated vaccine |
| title_fullStr | Case Report: A case of multisystem inflammatory syndrome in an 11-year-old female after COVID-19 inactivated vaccine |
| title_full_unstemmed | Case Report: A case of multisystem inflammatory syndrome in an 11-year-old female after COVID-19 inactivated vaccine |
| title_short | Case Report: A case of multisystem inflammatory syndrome in an 11-year-old female after COVID-19 inactivated vaccine |
| title_sort | case report a case of multisystem inflammatory syndrome in an 11 year old female after covid 19 inactivated vaccine |
| topic | SARS-CoV2 covid-19 inactivated vaccine multisystem inflammatory syndrome methylprednisolone coronavirus disease 2019 (COVID-19) |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1068301/full |
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