Effect of Tumor Location on the Risk of Bilateral Central Lymph Node Metastasis in Unilateral 1-4 cm Papillary Thyroid Carcinoma
Nan Liu, Bo Chen, Luchuan Li, Qingdong Zeng, Lei Sheng, Bin Zhang, Bin Lv Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, People’s Republic of ChinaCorrespondence: Bin LvDepartment of Thyroid Surgery, General Surgery, Qilu Hospital of Sh...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-07-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/effect-of-tumor-location-on-the-risk-of-bilateral-central-lymph-node-m-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1818671604431847424 |
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| author | Liu N Chen B Li L Zeng Q Sheng L Zhang B Lv B |
| author_facet | Liu N Chen B Li L Zeng Q Sheng L Zhang B Lv B |
| author_sort | Liu N |
| collection | DOAJ |
| description | Nan Liu, Bo Chen, Luchuan Li, Qingdong Zeng, Lei Sheng, Bin Zhang, Bin Lv Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, People’s Republic of ChinaCorrespondence: Bin LvDepartment of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, People’s Republic of ChinaEmail lvbin@sdu.edu.cnPurpose: Papillary thyroid carcinoma (PTC) has a high incidence of lymph node metastasis (LNM). Our aim was to determine whether tumor location is a useful feature to predict bilateral central lymph node metastasis (CLNM) in unilateral 1– 4 cm PTC.Patients and Methods: Data on unilateral 1– 4 cm PTC patients from 2016 to 2019 were collected retrospectively. The clinical and pathological characteristics of the tumors and lymph nodes were analyzed statistically.Results: The mean patient age was 49.1± 12.3 (23– 73) years, and the majority were women (n=1334, 75.4%). A total of 1767 patients were analyzed, and 256 (14.5%) had bilateral CLNM. Tumor location was an independent risk factor in predicting bilateral CLNM (p< 0.001). The odds of bilateral CLNM were the highest in the near isthmus (OR 6.452, 95% CI: 3.658– 11.379, p< 0.001). In a multivariate regression model adjusting for other risk factors, near-isthmus tumors had the highest risk of bilateral CLNM (OR 7.319, 95% CI: 3.844– 13.933, p< 0.001), followed by lower lobe tumors (OR 2.338, 95% CI: 1.315– 4.155, p=0.004) and middle lobe tumors (OR 1.845, 95% CI: 1.035– 3.291, p=0.038), compared to upper lobe tumors.Conclusion: Tumor location is an independent risk factor in predicting the risk of bilateral CLNM. Near-isthmus tumors carry the highest risk of bilateral CLNM.Keywords: papillary thyroid carcinoma, location, predictive factor, lymph node metastasis |
| first_indexed | 2024-12-17T07:26:39Z |
| format | Article |
| id | doaj.art-498e800a35c3403ba8238d88022ef17c |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-17T07:26:39Z |
| publishDate | 2021-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-498e800a35c3403ba8238d88022ef17c2022-12-21T21:58:37ZengDove Medical PressCancer Management and Research1179-13222021-07-01Volume 135803581267136Effect of Tumor Location on the Risk of Bilateral Central Lymph Node Metastasis in Unilateral 1-4 cm Papillary Thyroid CarcinomaLiu NChen BLi LZeng QSheng LZhang BLv BNan Liu, Bo Chen, Luchuan Li, Qingdong Zeng, Lei Sheng, Bin Zhang, Bin Lv Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, People’s Republic of ChinaCorrespondence: Bin LvDepartment of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, People’s Republic of ChinaEmail lvbin@sdu.edu.cnPurpose: Papillary thyroid carcinoma (PTC) has a high incidence of lymph node metastasis (LNM). Our aim was to determine whether tumor location is a useful feature to predict bilateral central lymph node metastasis (CLNM) in unilateral 1– 4 cm PTC.Patients and Methods: Data on unilateral 1– 4 cm PTC patients from 2016 to 2019 were collected retrospectively. The clinical and pathological characteristics of the tumors and lymph nodes were analyzed statistically.Results: The mean patient age was 49.1± 12.3 (23– 73) years, and the majority were women (n=1334, 75.4%). A total of 1767 patients were analyzed, and 256 (14.5%) had bilateral CLNM. Tumor location was an independent risk factor in predicting bilateral CLNM (p< 0.001). The odds of bilateral CLNM were the highest in the near isthmus (OR 6.452, 95% CI: 3.658– 11.379, p< 0.001). In a multivariate regression model adjusting for other risk factors, near-isthmus tumors had the highest risk of bilateral CLNM (OR 7.319, 95% CI: 3.844– 13.933, p< 0.001), followed by lower lobe tumors (OR 2.338, 95% CI: 1.315– 4.155, p=0.004) and middle lobe tumors (OR 1.845, 95% CI: 1.035– 3.291, p=0.038), compared to upper lobe tumors.Conclusion: Tumor location is an independent risk factor in predicting the risk of bilateral CLNM. Near-isthmus tumors carry the highest risk of bilateral CLNM.Keywords: papillary thyroid carcinoma, location, predictive factor, lymph node metastasishttps://www.dovepress.com/effect-of-tumor-location-on-the-risk-of-bilateral-central-lymph-node-m-peer-reviewed-fulltext-article-CMARpapillary thyroid carcinomalocationpredictive factorlymph node metastasis |
| spellingShingle | Liu N Chen B Li L Zeng Q Sheng L Zhang B Lv B Effect of Tumor Location on the Risk of Bilateral Central Lymph Node Metastasis in Unilateral 1-4 cm Papillary Thyroid Carcinoma Cancer Management and Research papillary thyroid carcinoma location predictive factor lymph node metastasis |
| title | Effect of Tumor Location on the Risk of Bilateral Central Lymph Node Metastasis in Unilateral 1-4 cm Papillary Thyroid Carcinoma |
| title_full | Effect of Tumor Location on the Risk of Bilateral Central Lymph Node Metastasis in Unilateral 1-4 cm Papillary Thyroid Carcinoma |
| title_fullStr | Effect of Tumor Location on the Risk of Bilateral Central Lymph Node Metastasis in Unilateral 1-4 cm Papillary Thyroid Carcinoma |
| title_full_unstemmed | Effect of Tumor Location on the Risk of Bilateral Central Lymph Node Metastasis in Unilateral 1-4 cm Papillary Thyroid Carcinoma |
| title_short | Effect of Tumor Location on the Risk of Bilateral Central Lymph Node Metastasis in Unilateral 1-4 cm Papillary Thyroid Carcinoma |
| title_sort | effect of tumor location on the risk of bilateral central lymph node metastasis in unilateral 1 4 cm papillary thyroid carcinoma |
| topic | papillary thyroid carcinoma location predictive factor lymph node metastasis |
| url | https://www.dovepress.com/effect-of-tumor-location-on-the-risk-of-bilateral-central-lymph-node-m-peer-reviewed-fulltext-article-CMAR |
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