Syntheses and Structural Investigations of Penta-Coordinated Co(II) Complexes with <i>Bis</i>-Pyrazolo-<i>S</i>-Triazine Pincer Ligands, and Evaluation of Their Antimicrobial and Antioxidant Activities
Two penta-coordinated <b>[Co(<sup>Morph</sup>BPT)Cl<sub>2</sub>]</b>; <b>1</b> and <b>[Co(<sup>Pip</sup>BPT)Cl<sub>2</sub>]</b>; <b>2</b> complexes with the <i>bis</i>-pyrazolyl-<i>s<...
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| author | Saied M. Soliman Raghdaa A. Massoud Hessa H. Al-Rasheed Ayman El-Faham |
| author_facet | Saied M. Soliman Raghdaa A. Massoud Hessa H. Al-Rasheed Ayman El-Faham |
| author_sort | Saied M. Soliman |
| collection | DOAJ |
| description | Two penta-coordinated <b>[Co(<sup>Morph</sup>BPT)Cl<sub>2</sub>]</b>; <b>1</b> and <b>[Co(<sup>Pip</sup>BPT)Cl<sub>2</sub>]</b>; <b>2</b> complexes with the <i>bis</i>-pyrazolyl-<i>s</i>-triazine pincer ligands <b><sup>Morph</sup>BPT</b> and <b><sup>Pip</sup>BPT</b> were synthesized and characterized. Both <b><sup>Morph</sup>BPT</b> and <b><sup>Pip</sup>BPT</b> act as NNN-tridentate pincer chelates coordinating the Co(II) center with one short Co-N(<i>s</i>-triazine) and two longer Co-N(pyrazole) bonds. The coordination number of Co(II) is five in both complexes, and the geometry around Co(II) ion is a distorted square pyramidal in <b>1,</b> while <b>2</b> shows more distortion. In both complexes, the packing is dominated by Cl…H, C-H…π, and Cl…C (anion-π stacking) interactions in addition to O…H interactions, which are found only in <b>1</b>. The UV-Vis spectral band at 564 nm was assigned to metal–ligand charge transfer transitions based on TD-DFT calculations. Complexes <b>1</b> and <b>2</b> showed higher antimicrobial activity compared to the respective free ligand <b><sup>Morph</sup></b><b>BPT</b> and <b><sup>Pip</sup>BPT,</b> which were not active. MIC values indicated that <b>2</b> had better activity against <i>S. aureus, B. subtilis</i>, and <i>P. vulgaris</i> than <b>1</b>. DPPH free radical scavenging assay revealed that all the studied compounds showed weak to moderate antioxidant activity where the nature of the substituent at the <i>s</i>-triazine core has a significant impact on the antioxidant activity. |
| first_indexed | 2024-03-10T10:25:18Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:25:18Z |
| publishDate | 2021-06-01 |
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| spelling | doaj.art-49911d514a9448acbc167e06496d62052023-11-22T00:03:23ZengMDPI AGMolecules1420-30492021-06-012612363310.3390/molecules26123633Syntheses and Structural Investigations of Penta-Coordinated Co(II) Complexes with <i>Bis</i>-Pyrazolo-<i>S</i>-Triazine Pincer Ligands, and Evaluation of Their Antimicrobial and Antioxidant ActivitiesSaied M. Soliman0Raghdaa A. Massoud1Hessa H. Al-Rasheed2Ayman El-Faham3Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, EgyptDepartment of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, EgyptDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, EgyptTwo penta-coordinated <b>[Co(<sup>Morph</sup>BPT)Cl<sub>2</sub>]</b>; <b>1</b> and <b>[Co(<sup>Pip</sup>BPT)Cl<sub>2</sub>]</b>; <b>2</b> complexes with the <i>bis</i>-pyrazolyl-<i>s</i>-triazine pincer ligands <b><sup>Morph</sup>BPT</b> and <b><sup>Pip</sup>BPT</b> were synthesized and characterized. Both <b><sup>Morph</sup>BPT</b> and <b><sup>Pip</sup>BPT</b> act as NNN-tridentate pincer chelates coordinating the Co(II) center with one short Co-N(<i>s</i>-triazine) and two longer Co-N(pyrazole) bonds. The coordination number of Co(II) is five in both complexes, and the geometry around Co(II) ion is a distorted square pyramidal in <b>1,</b> while <b>2</b> shows more distortion. In both complexes, the packing is dominated by Cl…H, C-H…π, and Cl…C (anion-π stacking) interactions in addition to O…H interactions, which are found only in <b>1</b>. The UV-Vis spectral band at 564 nm was assigned to metal–ligand charge transfer transitions based on TD-DFT calculations. Complexes <b>1</b> and <b>2</b> showed higher antimicrobial activity compared to the respective free ligand <b><sup>Morph</sup></b><b>BPT</b> and <b><sup>Pip</sup>BPT,</b> which were not active. MIC values indicated that <b>2</b> had better activity against <i>S. aureus, B. subtilis</i>, and <i>P. vulgaris</i> than <b>1</b>. DPPH free radical scavenging assay revealed that all the studied compounds showed weak to moderate antioxidant activity where the nature of the substituent at the <i>s</i>-triazine core has a significant impact on the antioxidant activity.https://www.mdpi.com/1420-3049/26/12/3633pincerpenta-coordinated Co(II)Hirshfeldantimicrobial activityantioxidant activity |
| spellingShingle | Saied M. Soliman Raghdaa A. Massoud Hessa H. Al-Rasheed Ayman El-Faham Syntheses and Structural Investigations of Penta-Coordinated Co(II) Complexes with <i>Bis</i>-Pyrazolo-<i>S</i>-Triazine Pincer Ligands, and Evaluation of Their Antimicrobial and Antioxidant Activities Molecules pincer penta-coordinated Co(II) Hirshfeld antimicrobial activity antioxidant activity |
| title | Syntheses and Structural Investigations of Penta-Coordinated Co(II) Complexes with <i>Bis</i>-Pyrazolo-<i>S</i>-Triazine Pincer Ligands, and Evaluation of Their Antimicrobial and Antioxidant Activities |
| title_full | Syntheses and Structural Investigations of Penta-Coordinated Co(II) Complexes with <i>Bis</i>-Pyrazolo-<i>S</i>-Triazine Pincer Ligands, and Evaluation of Their Antimicrobial and Antioxidant Activities |
| title_fullStr | Syntheses and Structural Investigations of Penta-Coordinated Co(II) Complexes with <i>Bis</i>-Pyrazolo-<i>S</i>-Triazine Pincer Ligands, and Evaluation of Their Antimicrobial and Antioxidant Activities |
| title_full_unstemmed | Syntheses and Structural Investigations of Penta-Coordinated Co(II) Complexes with <i>Bis</i>-Pyrazolo-<i>S</i>-Triazine Pincer Ligands, and Evaluation of Their Antimicrobial and Antioxidant Activities |
| title_short | Syntheses and Structural Investigations of Penta-Coordinated Co(II) Complexes with <i>Bis</i>-Pyrazolo-<i>S</i>-Triazine Pincer Ligands, and Evaluation of Their Antimicrobial and Antioxidant Activities |
| title_sort | syntheses and structural investigations of penta coordinated co ii complexes with i bis i pyrazolo i s i triazine pincer ligands and evaluation of their antimicrobial and antioxidant activities |
| topic | pincer penta-coordinated Co(II) Hirshfeld antimicrobial activity antioxidant activity |
| url | https://www.mdpi.com/1420-3049/26/12/3633 |
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