A cell therapy approach based on iPSC-derived midbrain organoids for the restoration of motor function in a Parkinson’s disease mouse model

A cell therapy approach based on iPSC-derived midbrain organoids for the restoration of motor function in a Parkinson’s disease mouse model

Parkinson's disease (PD) is a neurodegenerative disease characterized by the degeneration of dopaminergic (DA) neurons in the substantia nigra and loss of DA transmission in the striatum, thus making cell transplantation an effective treatment strategy. Here, we develop a cellular therapy based...

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Bibliographic Details
Main Authors: Chong-Lei Fu, Bo-Cheng Dong, Xi Jiang, Dan Li, Jun Yao
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Cell therapy
iPSC
Midbrain organoids
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024002652

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