Prevalence of respiratory bacterial co-infection among COVID-19 patients
Background and rationale: Since the beginning of COVID-19 pandemic, the number of cases and deaths increased. Bacterial co-infection was reported as one of the complications associated with increased mortality. This work aimed at exploring and describing the prevalence of respiratory bacterial co-i...
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| Format: | Article |
| Language: | English |
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Zagazig University, Faculty of Medicine
2023-11-01
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| Series: | Microbes and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mid.journals.ekb.eg/article_314197_5eefe843fcec05086fb60a13bf69a0ed.pdf |
| _version_ | 1797633567959810048 |
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| author | Eman Mohamed Marwa Elashry Noha Fahim |
| author_facet | Eman Mohamed Marwa Elashry Noha Fahim |
| author_sort | Eman Mohamed |
| collection | DOAJ |
| description | Background and rationale: Since the beginning of COVID-19 pandemic, the number of cases and deaths increased. Bacterial co-infection was reported as one of the complications associated with increased mortality. This work aimed at exploring and describing the prevalence of respiratory bacterial co-infection among COVID-19 patients in Ain Shams University Isolation Hospitals. Methodology: This study included 160 lower respiratory samples collected from 80 COVID-19 positive patients, and 80 COVID-19-negative patients admitted to Ain Shams University Isolation Hospitals between February and June 2021. Samples were cultured, and all recovered isolates were identified and tested for antibiotic susceptibility using Vitek2C. Results: Our results showed high prevalence of respiratory bacterial infections in males (106/160, 66.2%) than in females (54/160, 33.8%). The age ranged from 25-88 years (mean age 58.24 ± 14.19). In COVID-19-positive patients, 16/80 (20%) samples showed negative bacterial growth, and 64/80 (80%) were positive. In COVID-19-negative patients, 33/80 (41.25%) samples showed negative bacterial growth, and 47 (58.75%) showed bacterial growth. Klebsiella spp. was the most common isolated organism (51/148, 25.9%), followed by Acinetobacter spp. (50/148, 25.4%), and Stenotrophomonas (1/148, 0.5%) was the least common one. As per the Antibiotic susceptibility testing, a high resistance pattern was noticed among the isolated bacteria against all the tested antibiotics. Conclusion: COVID-19-positive patients showed higher positive bacterial growth than COVID-19 patients. Generally, a high resistance pattern was noticed among the isolated bacteria. The obtained results are alarm to the clinicians that they should halt the usage of empirical antimicrobials promptly and resort to culture and antimicrobial susceptibility testing. |
| first_indexed | 2024-03-11T11:55:42Z |
| format | Article |
| id | doaj.art-4995307b49474699abe082262edcbbfc |
| institution | Directory Open Access Journal |
| issn | 2682-4132 2682-4140 |
| language | English |
| last_indexed | 2024-03-11T11:55:42Z |
| publishDate | 2023-11-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj.art-4995307b49474699abe082262edcbbfc2023-11-08T19:05:38ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402023-11-01441114112510.21608/mid.2023.229096.1590314197Prevalence of respiratory bacterial co-infection among COVID-19 patientsEman Mohamed0Marwa Elashry1Noha Fahim2Department of Clinical and Chemical Pathology, Faculty of Medicine, Ain Shams University, Cairo, EgyptDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Ain Shams University, Cairo, EgyptDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Ain Shams University, Cairo, EgyptBackground and rationale: Since the beginning of COVID-19 pandemic, the number of cases and deaths increased. Bacterial co-infection was reported as one of the complications associated with increased mortality. This work aimed at exploring and describing the prevalence of respiratory bacterial co-infection among COVID-19 patients in Ain Shams University Isolation Hospitals. Methodology: This study included 160 lower respiratory samples collected from 80 COVID-19 positive patients, and 80 COVID-19-negative patients admitted to Ain Shams University Isolation Hospitals between February and June 2021. Samples were cultured, and all recovered isolates were identified and tested for antibiotic susceptibility using Vitek2C. Results: Our results showed high prevalence of respiratory bacterial infections in males (106/160, 66.2%) than in females (54/160, 33.8%). The age ranged from 25-88 years (mean age 58.24 ± 14.19). In COVID-19-positive patients, 16/80 (20%) samples showed negative bacterial growth, and 64/80 (80%) were positive. In COVID-19-negative patients, 33/80 (41.25%) samples showed negative bacterial growth, and 47 (58.75%) showed bacterial growth. Klebsiella spp. was the most common isolated organism (51/148, 25.9%), followed by Acinetobacter spp. (50/148, 25.4%), and Stenotrophomonas (1/148, 0.5%) was the least common one. As per the Antibiotic susceptibility testing, a high resistance pattern was noticed among the isolated bacteria against all the tested antibiotics. Conclusion: COVID-19-positive patients showed higher positive bacterial growth than COVID-19 patients. Generally, a high resistance pattern was noticed among the isolated bacteria. The obtained results are alarm to the clinicians that they should halt the usage of empirical antimicrobials promptly and resort to culture and antimicrobial susceptibility testing.https://mid.journals.ekb.eg/article_314197_5eefe843fcec05086fb60a13bf69a0ed.pdfkeywords: covid-19bacterial co-infectionmultidrug resistanceprevalencerespiratory infection |
| spellingShingle | Eman Mohamed Marwa Elashry Noha Fahim Prevalence of respiratory bacterial co-infection among COVID-19 patients Microbes and Infectious Diseases keywords: covid-19 bacterial co-infection multidrug resistance prevalence respiratory infection |
| title | Prevalence of respiratory bacterial co-infection among COVID-19 patients |
| title_full | Prevalence of respiratory bacterial co-infection among COVID-19 patients |
| title_fullStr | Prevalence of respiratory bacterial co-infection among COVID-19 patients |
| title_full_unstemmed | Prevalence of respiratory bacterial co-infection among COVID-19 patients |
| title_short | Prevalence of respiratory bacterial co-infection among COVID-19 patients |
| title_sort | prevalence of respiratory bacterial co infection among covid 19 patients |
| topic | keywords: covid-19 bacterial co-infection multidrug resistance prevalence respiratory infection |
| url | https://mid.journals.ekb.eg/article_314197_5eefe843fcec05086fb60a13bf69a0ed.pdf |
| work_keys_str_mv | AT emanmohamed prevalenceofrespiratorybacterialcoinfectionamongcovid19patients AT marwaelashry prevalenceofrespiratorybacterialcoinfectionamongcovid19patients AT nohafahim prevalenceofrespiratorybacterialcoinfectionamongcovid19patients |