The relationship between serum thyroid hormone levels, subclinical hypothyroidism, and coronary collateral circulation in patients with stable coronary artery disease
Objective: Thyroid disease is a common endocrine disease with important effects on the cardiovascular system. As an adaptive response to myocardial ischemia, coronary collateral circulation (CCC) plays an important role in obstructive coronary artery disease (CAD). The association between serum thy...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2016-04-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-00905 |
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| author | Mehmet Ballı Mustafa Çetin Hakan Taşolar Onur Kadir Uysal Mahmut Yılmaz Mine Durukan Zafer Elbasan Murat Çaylı |
| author_facet | Mehmet Ballı Mustafa Çetin Hakan Taşolar Onur Kadir Uysal Mahmut Yılmaz Mine Durukan Zafer Elbasan Murat Çaylı |
| author_sort | Mehmet Ballı |
| collection | DOAJ |
| description | Objective: Thyroid disease is a common endocrine disease with important effects on the cardiovascular system. As an adaptive response to myocardial ischemia, coronary collateral circulation (CCC) plays an important role in obstructive coronary artery disease (CAD). The association between serum thyroid hormone levels and development of CCC was investigated in the present study.
Methods: In total, 430 consecutive patients who underwent coronary angiography procedure and had documented total occlusion in at least 1 major coronary artery were investigated retrospectively. Degree of CCC was classified according to Cohen-Rentrop method. Serum free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) were assessed by the chemiluminescence immunoassay technique.
Results: In spite of diabetes mellitus (p=0.019), smoking (p<0.001), and TSH (p<0.001), FT3 (p<0.001), FT4 (p=0.015), and subclinical hypothyroidism (SCH) (p<0.001) ratios were significantly different between groups. In regression analysis, SCH (p=0.024), DM (p=0.021), smoking (p<0.001), and heart failure (p=0.029) were independent predictors of poor CCC development in multivariate model 1. When regression analyses were performed based on multivariate model 2, TSH (p<0.001), FT3 (p<0.001), heart failure (p=0.022), smoking (p<0.001), and hyperlipidemia (HPL) (p=0.046) were independent predictors of poor CCC development.
Conclusion: In addition to traditional risk factors, SCH, higher serum TSH, and lower FT3 levels were associated with development of poor CCC in patients with obstructive CAD. |
| first_indexed | 2024-04-10T12:23:10Z |
| format | Article |
| id | doaj.art-4997141227ce4fe9bdd83d24701dbcda |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T12:23:10Z |
| publishDate | 2016-04-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-4997141227ce4fe9bdd83d24701dbcda2023-02-15T16:15:22ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692016-04-0144213013610.5543/tkda.2015.00905TKDA-00905The relationship between serum thyroid hormone levels, subclinical hypothyroidism, and coronary collateral circulation in patients with stable coronary artery diseaseMehmet Ballı0Mustafa Çetin1Hakan Taşolar2Onur Kadir Uysal3Mahmut Yılmaz4Mine Durukan5Zafer Elbasan6Murat Çaylı7Department of Cardiology, Mersin Toros State Hospital, Mersin, TurkeyDepartment of Cardiology, Adiyaman University Training and Research Hospital, Adıyaman, TurkeyDepartment of Cardiology, Adiyaman University Training and Research Hospital, Adıyaman, TurkeyDepartment of Cardiology, Kayseri Training and Research Hospital, Kayseri, TurkeyDepartment of Cardiology, Mersin Toros State Hospital, Mersin, TurkeyDepartment of Cardiology, Mersin Toros State Hospital, Mersin, TurkeyDepermant of Cardiology, Adana Numune Training and Research Hospital, Adana, TurkeyDepermant of Cardiology, Adana Numune Training and Research Hospital, Adana, TurkeyObjective: Thyroid disease is a common endocrine disease with important effects on the cardiovascular system. As an adaptive response to myocardial ischemia, coronary collateral circulation (CCC) plays an important role in obstructive coronary artery disease (CAD). The association between serum thyroid hormone levels and development of CCC was investigated in the present study. Methods: In total, 430 consecutive patients who underwent coronary angiography procedure and had documented total occlusion in at least 1 major coronary artery were investigated retrospectively. Degree of CCC was classified according to Cohen-Rentrop method. Serum free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) were assessed by the chemiluminescence immunoassay technique. Results: In spite of diabetes mellitus (p=0.019), smoking (p<0.001), and TSH (p<0.001), FT3 (p<0.001), FT4 (p=0.015), and subclinical hypothyroidism (SCH) (p<0.001) ratios were significantly different between groups. In regression analysis, SCH (p=0.024), DM (p=0.021), smoking (p<0.001), and heart failure (p=0.029) were independent predictors of poor CCC development in multivariate model 1. When regression analyses were performed based on multivariate model 2, TSH (p<0.001), FT3 (p<0.001), heart failure (p=0.022), smoking (p<0.001), and hyperlipidemia (HPL) (p=0.046) were independent predictors of poor CCC development. Conclusion: In addition to traditional risk factors, SCH, higher serum TSH, and lower FT3 levels were associated with development of poor CCC in patients with obstructive CAD.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-00905coronary collateral circulationsubclinical hypothyroidism; throid hormones |
| spellingShingle | Mehmet Ballı Mustafa Çetin Hakan Taşolar Onur Kadir Uysal Mahmut Yılmaz Mine Durukan Zafer Elbasan Murat Çaylı The relationship between serum thyroid hormone levels, subclinical hypothyroidism, and coronary collateral circulation in patients with stable coronary artery disease Türk Kardiyoloji Derneği Arşivi coronary collateral circulation subclinical hypothyroidism; throid hormones |
| title | The relationship between serum thyroid hormone levels, subclinical hypothyroidism, and coronary collateral circulation in patients with stable coronary artery disease |
| title_full | The relationship between serum thyroid hormone levels, subclinical hypothyroidism, and coronary collateral circulation in patients with stable coronary artery disease |
| title_fullStr | The relationship between serum thyroid hormone levels, subclinical hypothyroidism, and coronary collateral circulation in patients with stable coronary artery disease |
| title_full_unstemmed | The relationship between serum thyroid hormone levels, subclinical hypothyroidism, and coronary collateral circulation in patients with stable coronary artery disease |
| title_short | The relationship between serum thyroid hormone levels, subclinical hypothyroidism, and coronary collateral circulation in patients with stable coronary artery disease |
| title_sort | relationship between serum thyroid hormone levels subclinical hypothyroidism and coronary collateral circulation in patients with stable coronary artery disease |
| topic | coronary collateral circulation subclinical hypothyroidism; throid hormones |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-00905 |
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