Liraglutide and Exercise: A Possible Treatment for Obesity?
(1) Background: Obesity has become an important public health problem worldwide, and its characterization as a chronic disease reflects the impact of a complex and multifactorial condition. The treatment for obesity is based on lifestyle interventions that induce a negative energy balance. However,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Obesities |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4168/2/3/23 |
| _version_ | 1797483927292608512 |
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| author | Ana Paula Azevêdo Macêdo Renan Fudoli Lins Vieira Guilherme Domingos Brisque Gabriela Ferreira Abud José Rodrigo Pauli |
| author_facet | Ana Paula Azevêdo Macêdo Renan Fudoli Lins Vieira Guilherme Domingos Brisque Gabriela Ferreira Abud José Rodrigo Pauli |
| author_sort | Ana Paula Azevêdo Macêdo |
| collection | DOAJ |
| description | (1) Background: Obesity has become an important public health problem worldwide, and its characterization as a chronic disease reflects the impact of a complex and multifactorial condition. The treatment for obesity is based on lifestyle interventions that induce a negative energy balance. However, adherence to a lifestyle intervention is a challenge for many overweight and obese people. Thus, pharmacotherapy in the management of obesity is used to increase patient adherence to lifestyle changes and overcome the biological adaptations that occur with weight loss. Among these drugs, liraglutide stands out. Liraglutide is an analog of human glucagon-like peptide-1 (GLP-1), a hormone that regulates glucose-dependent insulin secretion, and glucagon release. (2) Results: Liraglutide appears to be effective in weight reduction and glycemic control in diabetic and obese patients, and combination of liraglutide and exercise can also bring benefits in weight loss. Furthermore, the combination of liraglutide and physical exercise can prevent adverse effects observed in the administration of liraglutide. (3) Conclusions: liraglutide seems to contribute to cardiometabolic improvement in obese individuals with or without diabetes, and the combination of liraglutide and physical exercise can prevent adverse effects observed in the administration of liraglutide. |
| first_indexed | 2024-03-09T22:54:04Z |
| format | Article |
| id | doaj.art-499755fa051b44d290e2e38db8c6705d |
| institution | Directory Open Access Journal |
| issn | 2673-4168 |
| language | English |
| last_indexed | 2024-03-09T22:54:04Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Obesities |
| spelling | doaj.art-499755fa051b44d290e2e38db8c6705d2023-11-23T18:13:51ZengMDPI AGObesities2673-41682022-08-012328529110.3390/obesities2030023Liraglutide and Exercise: A Possible Treatment for Obesity?Ana Paula Azevêdo Macêdo0Renan Fudoli Lins Vieira1Guilherme Domingos Brisque2Gabriela Ferreira Abud3José Rodrigo Pauli4Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira 13484-350, SP, BrazilLaboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira 13484-350, SP, BrazilLaboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira 13484-350, SP, BrazilDepartment of Health Sciences, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, SP, BrazilLaboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira 13484-350, SP, Brazil(1) Background: Obesity has become an important public health problem worldwide, and its characterization as a chronic disease reflects the impact of a complex and multifactorial condition. The treatment for obesity is based on lifestyle interventions that induce a negative energy balance. However, adherence to a lifestyle intervention is a challenge for many overweight and obese people. Thus, pharmacotherapy in the management of obesity is used to increase patient adherence to lifestyle changes and overcome the biological adaptations that occur with weight loss. Among these drugs, liraglutide stands out. Liraglutide is an analog of human glucagon-like peptide-1 (GLP-1), a hormone that regulates glucose-dependent insulin secretion, and glucagon release. (2) Results: Liraglutide appears to be effective in weight reduction and glycemic control in diabetic and obese patients, and combination of liraglutide and exercise can also bring benefits in weight loss. Furthermore, the combination of liraglutide and physical exercise can prevent adverse effects observed in the administration of liraglutide. (3) Conclusions: liraglutide seems to contribute to cardiometabolic improvement in obese individuals with or without diabetes, and the combination of liraglutide and physical exercise can prevent adverse effects observed in the administration of liraglutide.https://www.mdpi.com/2673-4168/2/3/23liraglutidephysical trainingobese |
| spellingShingle | Ana Paula Azevêdo Macêdo Renan Fudoli Lins Vieira Guilherme Domingos Brisque Gabriela Ferreira Abud José Rodrigo Pauli Liraglutide and Exercise: A Possible Treatment for Obesity? Obesities liraglutide physical training obese |
| title | Liraglutide and Exercise: A Possible Treatment for Obesity? |
| title_full | Liraglutide and Exercise: A Possible Treatment for Obesity? |
| title_fullStr | Liraglutide and Exercise: A Possible Treatment for Obesity? |
| title_full_unstemmed | Liraglutide and Exercise: A Possible Treatment for Obesity? |
| title_short | Liraglutide and Exercise: A Possible Treatment for Obesity? |
| title_sort | liraglutide and exercise a possible treatment for obesity |
| topic | liraglutide physical training obese |
| url | https://www.mdpi.com/2673-4168/2/3/23 |
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