Emerging roles of PHLPP phosphatases in lung cancer
Pleckstrin homologous domain leucine-rich repeating protein phosphatases (PHLPPs) were originally identified as protein kinase B (Akt) kinase hydrophobic motif specific phosphatases to maintain the cellular homeostasis. With the continuous expansion of PHLPPs research, imbalanced-PHLPPs were mainly...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1216131/full |
| _version_ | 1797770949204901888 |
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| author | Xinhang Xia Wenhu Pi Meng Chen Wei Wang Danyang Cai Xuequan Wang Yanli Lan Haihua Yang |
| author_facet | Xinhang Xia Wenhu Pi Meng Chen Wei Wang Danyang Cai Xuequan Wang Yanli Lan Haihua Yang |
| author_sort | Xinhang Xia |
| collection | DOAJ |
| description | Pleckstrin homologous domain leucine-rich repeating protein phosphatases (PHLPPs) were originally identified as protein kinase B (Akt) kinase hydrophobic motif specific phosphatases to maintain the cellular homeostasis. With the continuous expansion of PHLPPs research, imbalanced-PHLPPs were mainly found as a tumor suppressor gene of a variety of solid tumors. In this review, we simply described the history and structures of PHLPPs and summarized the recent achievements in emerging roles of PHLPPs in lung cancer by 1) the signaling pathways affected by PHLPPs including Phosphoinositide 3-kinase (PI3K)/AKT, RAS/RAF/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and Protein kinase C (PKC) signaling cascades. 2) function of PHLPPs regulatory factor USP46 and miR-190/miR-215, 3) the potential roles of PHLPPs in disease prognosis, Epidermal growth factor receptors (EGFR)- tyrosine kinase inhibitor (TKI) resistance and DNA damage, 4) and the possible function of PHLPPs in radiotherapy, ferroptosis and inflammation response. Therefore, PHLPPs can be considered as either biomarker or prognostic marker for lung cancer treatment. |
| first_indexed | 2024-03-12T21:30:26Z |
| format | Article |
| id | doaj.art-49987f1ee92645c9a631ba00429fe061 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T21:30:26Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-49987f1ee92645c9a631ba00429fe0612023-07-27T21:36:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-07-011310.3389/fonc.2023.12161311216131Emerging roles of PHLPP phosphatases in lung cancerXinhang XiaWenhu PiMeng ChenWei WangDanyang CaiXuequan WangYanli LanHaihua YangPleckstrin homologous domain leucine-rich repeating protein phosphatases (PHLPPs) were originally identified as protein kinase B (Akt) kinase hydrophobic motif specific phosphatases to maintain the cellular homeostasis. With the continuous expansion of PHLPPs research, imbalanced-PHLPPs were mainly found as a tumor suppressor gene of a variety of solid tumors. In this review, we simply described the history and structures of PHLPPs and summarized the recent achievements in emerging roles of PHLPPs in lung cancer by 1) the signaling pathways affected by PHLPPs including Phosphoinositide 3-kinase (PI3K)/AKT, RAS/RAF/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and Protein kinase C (PKC) signaling cascades. 2) function of PHLPPs regulatory factor USP46 and miR-190/miR-215, 3) the potential roles of PHLPPs in disease prognosis, Epidermal growth factor receptors (EGFR)- tyrosine kinase inhibitor (TKI) resistance and DNA damage, 4) and the possible function of PHLPPs in radiotherapy, ferroptosis and inflammation response. Therefore, PHLPPs can be considered as either biomarker or prognostic marker for lung cancer treatment.https://www.frontiersin.org/articles/10.3389/fonc.2023.1216131/fullPHLPPlung cancerphosphatase substratetherapeutic targetpotential effect |
| spellingShingle | Xinhang Xia Wenhu Pi Meng Chen Wei Wang Danyang Cai Xuequan Wang Yanli Lan Haihua Yang Emerging roles of PHLPP phosphatases in lung cancer Frontiers in Oncology PHLPP lung cancer phosphatase substrate therapeutic target potential effect |
| title | Emerging roles of PHLPP phosphatases in lung cancer |
| title_full | Emerging roles of PHLPP phosphatases in lung cancer |
| title_fullStr | Emerging roles of PHLPP phosphatases in lung cancer |
| title_full_unstemmed | Emerging roles of PHLPP phosphatases in lung cancer |
| title_short | Emerging roles of PHLPP phosphatases in lung cancer |
| title_sort | emerging roles of phlpp phosphatases in lung cancer |
| topic | PHLPP lung cancer phosphatase substrate therapeutic target potential effect |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1216131/full |
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