Progress in exosome associated tumor markers and their detection methods
Abstract Exosomes are secreted by cells and are widely present in body fluids. Exosomes contain various molecular constituents of their cells of origin such as proteins, mRNA, miRNAs, DNA, lipid and glycans which are very similar as the content in tumor cells. These contents play an important role i...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2020-08-01
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| Series: | Molecular Biomedicine |
| Online Access: | https://doi.org/10.1186/s43556-020-00002-3 |
| _version_ | 1818903149736361984 |
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| author | Mengjiao Shen Kaili Di Hongzhang He Yanyan Xia Hui Xie Rongrong Huang Chang Liu Mo Yang Siyang Zheng Nongyue He Zhiyang Li |
| author_facet | Mengjiao Shen Kaili Di Hongzhang He Yanyan Xia Hui Xie Rongrong Huang Chang Liu Mo Yang Siyang Zheng Nongyue He Zhiyang Li |
| author_sort | Mengjiao Shen |
| collection | DOAJ |
| description | Abstract Exosomes are secreted by cells and are widely present in body fluids. Exosomes contain various molecular constituents of their cells of origin such as proteins, mRNA, miRNAs, DNA, lipid and glycans which are very similar as the content in tumor cells. These contents play an important role in various stages of tumor development, and make the tumor-derived exosome as a hot and emerging biomarker for various cancers diagnosis and management in non-invasive manner. The present problems of exosome isolation and detection hinder the application of exosomes. With the development of exosome isolation and detection technology, the contents of exosomes can be exploited for early cancer diagnosis. This review summarizes the recent progress on exosome-associated tumor biomarkers and some new technologies for exosome isolation and detection. Furthermore, we have also discussed the future development direction in exosome analysis methods. |
| first_indexed | 2024-12-19T20:46:57Z |
| format | Article |
| id | doaj.art-4999772f865148f4a4ef216eccfc0176 |
| institution | Directory Open Access Journal |
| issn | 2662-8651 |
| language | English |
| last_indexed | 2024-12-19T20:46:57Z |
| publishDate | 2020-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Molecular Biomedicine |
| spelling | doaj.art-4999772f865148f4a4ef216eccfc01762022-12-21T20:06:12ZengSpringerMolecular Biomedicine2662-86512020-08-011112510.1186/s43556-020-00002-3Progress in exosome associated tumor markers and their detection methodsMengjiao Shen0Kaili Di1Hongzhang He2Yanyan Xia3Hui Xie4Rongrong Huang5Chang Liu6Mo Yang7Siyang Zheng8Nongyue He9Zhiyang Li10Department of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolCaptis Diagnostics IncDepartment of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Biomedical Engineering, the Hong Kong Polytechnic UniversityDepartment of Biomedical Engineering and Electrical & Computer Engineering, Carnegie Mellon UniversityState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast UniversityDepartment of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolAbstract Exosomes are secreted by cells and are widely present in body fluids. Exosomes contain various molecular constituents of their cells of origin such as proteins, mRNA, miRNAs, DNA, lipid and glycans which are very similar as the content in tumor cells. These contents play an important role in various stages of tumor development, and make the tumor-derived exosome as a hot and emerging biomarker for various cancers diagnosis and management in non-invasive manner. The present problems of exosome isolation and detection hinder the application of exosomes. With the development of exosome isolation and detection technology, the contents of exosomes can be exploited for early cancer diagnosis. This review summarizes the recent progress on exosome-associated tumor biomarkers and some new technologies for exosome isolation and detection. Furthermore, we have also discussed the future development direction in exosome analysis methods.https://doi.org/10.1186/s43556-020-00002-3 |
| spellingShingle | Mengjiao Shen Kaili Di Hongzhang He Yanyan Xia Hui Xie Rongrong Huang Chang Liu Mo Yang Siyang Zheng Nongyue He Zhiyang Li Progress in exosome associated tumor markers and their detection methods Molecular Biomedicine |
| title | Progress in exosome associated tumor markers and their detection methods |
| title_full | Progress in exosome associated tumor markers and their detection methods |
| title_fullStr | Progress in exosome associated tumor markers and their detection methods |
| title_full_unstemmed | Progress in exosome associated tumor markers and their detection methods |
| title_short | Progress in exosome associated tumor markers and their detection methods |
| title_sort | progress in exosome associated tumor markers and their detection methods |
| url | https://doi.org/10.1186/s43556-020-00002-3 |
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