Factors associated with β-blocker initiation and discontinuation in a population-based cohort of seniors newly diagnosed with heart failure
Catherine Girouard,1–3 Jean-Pierre Grégoire,1–3 Paul Poirier,2,4 Jocelyne Moisan1–3 1Chair on Adherence to Treatments, Université Laval, 2Faculty of Pharmacy, Université Laval, 3Population Health and Optimal Health Practices Research Un...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-09-01
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| Series: | Patient Preference and Adherence |
| Subjects: | |
| Online Access: | https://www.dovepress.com/factors-associated-with-beta-blocker-initiation-and-discontinuation-in-peer-reviewed-article-PPA |
| _version_ | 1811253129536077824 |
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| author | Girouard C Grégoire JP Poirier P Moisan J |
| author_facet | Girouard C Grégoire JP Poirier P Moisan J |
| author_sort | Girouard C |
| collection | DOAJ |
| description | Catherine Girouard,1–3 Jean-Pierre Grégoire,1–3 Paul Poirier,2,4 Jocelyne Moisan1–3 1Chair on Adherence to Treatments, Université Laval, 2Faculty of Pharmacy, Université Laval, 3Population Health and Optimal Health Practices Research Unit, CHU de Québec Research Center, 4Quebec Heart and Lung Institute-Université Laval, Quebec City, QC, Canada Purpose: β-Blockers (bisoprolol, carvedilol, and metoprolol) are the cornerstone of heart failure (HF) management. The incidence rate of β-blocker initiation and discontinuation and their associated factors among seniors with a first HF diagnosis were assessed.Methods: A population-based inception cohort study that included all individuals aged ≥65 years with a first HF diagnosis in Quebec was conducted. β-Blockers initiation among 91,131 patients who were not using β-blockers at the time of HF diagnosis and discontinuation among those who initiated a β-blocker after HF diagnosis were assessed. Stepwise Cox regression analyses were used to calculate hazard ratios (HR) and to identify factors associated with β-blocker initiation and discontinuation.Results: After HF diagnosis, 32,989 (36.2%) individuals initiated a β-blocker. Of these, 15,408 (46.7%) discontinued their β-blocker during the follow-up. Individuals more likely to initiate a β-blocker were those diagnosed in a recent calendar year (2009: HR, 2.11; 95% confidence interval [CI], 2.00–2.23) and diagnosed by a cardiologist (HR, 1.38; 95% CI, 1.34–1.42). Individuals less likely to initiate were those aged ≥90 years (HR, 0.65; 95% CI, 0.61–0.68) and those with chronic obstructive pulmonary disease (HR, 0.66; 95% CI, 0.64–0.68). Individuals more likely to discontinue were those with more than nine medical consultations (HR, 1.14; 95% CI, 1.10–1.18) and those with dementia (HR, 1.13; 95% CI, 1.01–1.27). Individuals less likely to discontinue were those diagnosed in a recent calendar year (2009: HR 0.74; 95% CI, 0.65–0.82) and those exposed to another β-blocker before HF diagnosis (HR, 0.88; 95% CI, 0.85–0.91).Conclusion: Quebec seniors seem to be underexposed to β-blocker following HF diagnosis. Among those who initiate β-blocker use, discontinuation is high. Better understanding of the underlying causes is needed to help target interventions to improve the management of HF. Keywords: heart failure, β-blocker initiation, β-blocker discontinuation, cohort study, drug use |
| first_indexed | 2024-04-12T16:46:02Z |
| format | Article |
| id | doaj.art-49999a92df1a458e9029783430a789f1 |
| institution | Directory Open Access Journal |
| issn | 1177-889X |
| language | English |
| last_indexed | 2024-04-12T16:46:02Z |
| publishDate | 2016-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj.art-49999a92df1a458e9029783430a789f12022-12-22T03:24:35ZengDove Medical PressPatient Preference and Adherence1177-889X2016-09-01Volume 101811182128941Factors associated with β-blocker initiation and discontinuation in a population-based cohort of seniors newly diagnosed with heart failureGirouard CGrégoire JPPoirier PMoisan JCatherine Girouard,1–3 Jean-Pierre Grégoire,1–3 Paul Poirier,2,4 Jocelyne Moisan1–3 1Chair on Adherence to Treatments, Université Laval, 2Faculty of Pharmacy, Université Laval, 3Population Health and Optimal Health Practices Research Unit, CHU de Québec Research Center, 4Quebec Heart and Lung Institute-Université Laval, Quebec City, QC, Canada Purpose: β-Blockers (bisoprolol, carvedilol, and metoprolol) are the cornerstone of heart failure (HF) management. The incidence rate of β-blocker initiation and discontinuation and their associated factors among seniors with a first HF diagnosis were assessed.Methods: A population-based inception cohort study that included all individuals aged ≥65 years with a first HF diagnosis in Quebec was conducted. β-Blockers initiation among 91,131 patients who were not using β-blockers at the time of HF diagnosis and discontinuation among those who initiated a β-blocker after HF diagnosis were assessed. Stepwise Cox regression analyses were used to calculate hazard ratios (HR) and to identify factors associated with β-blocker initiation and discontinuation.Results: After HF diagnosis, 32,989 (36.2%) individuals initiated a β-blocker. Of these, 15,408 (46.7%) discontinued their β-blocker during the follow-up. Individuals more likely to initiate a β-blocker were those diagnosed in a recent calendar year (2009: HR, 2.11; 95% confidence interval [CI], 2.00–2.23) and diagnosed by a cardiologist (HR, 1.38; 95% CI, 1.34–1.42). Individuals less likely to initiate were those aged ≥90 years (HR, 0.65; 95% CI, 0.61–0.68) and those with chronic obstructive pulmonary disease (HR, 0.66; 95% CI, 0.64–0.68). Individuals more likely to discontinue were those with more than nine medical consultations (HR, 1.14; 95% CI, 1.10–1.18) and those with dementia (HR, 1.13; 95% CI, 1.01–1.27). Individuals less likely to discontinue were those diagnosed in a recent calendar year (2009: HR 0.74; 95% CI, 0.65–0.82) and those exposed to another β-blocker before HF diagnosis (HR, 0.88; 95% CI, 0.85–0.91).Conclusion: Quebec seniors seem to be underexposed to β-blocker following HF diagnosis. Among those who initiate β-blocker use, discontinuation is high. Better understanding of the underlying causes is needed to help target interventions to improve the management of HF. Keywords: heart failure, β-blocker initiation, β-blocker discontinuation, cohort study, drug usehttps://www.dovepress.com/factors-associated-with-beta-blocker-initiation-and-discontinuation-in-peer-reviewed-article-PPAheart failureseniorsβ-blocker initiationβ-blocker discontinuationfactors. |
| spellingShingle | Girouard C Grégoire JP Poirier P Moisan J Factors associated with β-blocker initiation and discontinuation in a population-based cohort of seniors newly diagnosed with heart failure Patient Preference and Adherence heart failure seniors β-blocker initiation β-blocker discontinuation factors. |
| title | Factors associated with β-blocker initiation and discontinuation in a population-based cohort of seniors newly diagnosed with heart failure |
| title_full | Factors associated with β-blocker initiation and discontinuation in a population-based cohort of seniors newly diagnosed with heart failure |
| title_fullStr | Factors associated with β-blocker initiation and discontinuation in a population-based cohort of seniors newly diagnosed with heart failure |
| title_full_unstemmed | Factors associated with β-blocker initiation and discontinuation in a population-based cohort of seniors newly diagnosed with heart failure |
| title_short | Factors associated with β-blocker initiation and discontinuation in a population-based cohort of seniors newly diagnosed with heart failure |
| title_sort | factors associated with beta blocker initiation and discontinuation in a population based cohort of seniors newly diagnosed with heart failure |
| topic | heart failure seniors β-blocker initiation β-blocker discontinuation factors. |
| url | https://www.dovepress.com/factors-associated-with-beta-blocker-initiation-and-discontinuation-in-peer-reviewed-article-PPA |
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