Generating real-world evidence compatible with evidence from randomized controlled trials: a novel observational study design applicable to surgical transfusion research

Generating real-world evidence compatible with evidence from randomized controlled trials: a novel observational study design applicable to surgical transfusion research

Abstract Background Numerous observational studies have revealed an increased risk of death and complications with transfusion, but this observation has not been confirmed in randomized controlled trials (RCTs). The “transfusion kills patients” paradox persists in real-world observational studies de...

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Bibliographic Details
Main Authors: Xiaochu Yu, Zixing Wang, Lei Wang, Yuguang Huang, Yipeng Wang, Shijie Xin, Guanghua Lei, Shengxiu Zhao, Yali Chen, Xiaobo Guo, Wei Han, Xuerong Yu, Fang Xue, Peng Wu, Wentao Gu, Jingmei Jiang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Medical Research Methodology
Subjects:
Study design
Bias by indication
Propensity score
Transfusion
Patient outcome
Online Access:https://doi.org/10.1186/s12874-022-01787-3

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