The impact of HIV infection and disease stage on the rate of weight gain and duration of refeeding and treatment in severely malnourished children in rural South African hospitals
Background. Evidence of the effects of HIV infection and clinical stage on the duration of refeeding and treatment (DRT) and the rate of weight gain (RWG) in severely malnourished children remains inconclusive. Objectives. To determine whether the RWG and DRT differ by baseline clinical characteris...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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South African Medical Association
2017-07-01
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| Series: | South African Journal of Child Health |
| Online Access: | http://www.sajch.org.za/index.php/SAJCH/article/view/1374/775 |
| _version_ | 1797329050845315072 |
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| author | Moïse Muzigaba Benn Sartorius Thandi Puoane Brian Van Wyk David Sanders |
| author_facet | Moïse Muzigaba Benn Sartorius Thandi Puoane Brian Van Wyk David Sanders |
| author_sort | Moïse Muzigaba |
| collection | DOAJ |
| description | Background. Evidence of the effects of HIV infection and clinical stage on the duration of refeeding and treatment (DRT) and the rate of weight gain (RWG) in severely malnourished children remains inconclusive.
Objectives. To determine whether the RWG and DRT differ by baseline clinical characteristics, and to assess the effect of HIV status and disease stage on the relationship between these two clinical outcomes.
Methods. This was a retrospective record review of 346 patiens discharged between 2009 and 2013 following treatment for severe acute malnutrition (SAM) at two rural hospitals in South Africa.
Results. A third of the sample was HIV-positive, the RWG (measured as g/kg/day) was significantly slower in HIV-positive patients compared with HIV-negative cases (mean 5.2, 95% confidence interval (CI) 4.47 - 5.93 v. mean 8.51; CI 7.98 - 9.05; p<0.0001) and cases at stage IV of HIV infection had a significantly slower RWG (mean 3.97; CI 2.33 - 5.61) compared with those at stages I (mean 7.64; CI 6.21 - 9.07) (p<0.0001) and II (mean 5.87; CI 4.74 - 6.99). The mean DRT was longer in HIV-positive cases and those at advanced stages of HIV infection. HIV-positive cases were renourished and treated for almost 3.5 times longer than their HIV-negative counterparts to achieve a moderate RWG (5 - 10 g/kg/day).
Conclusion. This study highlights the need to reconsider energy requirements for HIV-positive cases at different clinical stages, for more rapid nutritional recovery in under-resourced settings where prolonged hospitalisation may be a challenge. |
| first_indexed | 2024-03-08T07:00:37Z |
| format | Article |
| id | doaj.art-499de4c24f7144b5a1b912e18fb17e4f |
| institution | Directory Open Access Journal |
| issn | 1994-3032 1999-7671 |
| language | English |
| last_indexed | 2024-03-08T07:00:37Z |
| publishDate | 2017-07-01 |
| publisher | South African Medical Association |
| record_format | Article |
| series | South African Journal of Child Health |
| spelling | doaj.art-499de4c24f7144b5a1b912e18fb17e4f2024-02-03T05:59:12ZengSouth African Medical AssociationSouth African Journal of Child Health1994-30321999-76712017-07-01112869210.7196/SAJCH.2017.v11i2.1194The impact of HIV infection and disease stage on the rate of weight gain and duration of refeeding and treatment in severely malnourished children in rural South African hospitalsMoïse Muzigaba0Benn Sartorius1Thandi Puoane2Brian Van Wyk3David Sanders4School of Clinical Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa;Faculty of Community and Health Sciences, School of Public Health, University of the Western Cape, Bellville, South AfricaDiscipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South AfricaFaculty of Community and Health Sciences, School of Public Health, University of the Western Cape, Bellville, South AfricaFaculty of Community and Health Sciences, School of Public Health, University of the Western Cape, Bellville, South AfricaFaculty of Community and Health Sciences, School of Public Health, University of the Western Cape, Bellville, South AfricaBackground. Evidence of the effects of HIV infection and clinical stage on the duration of refeeding and treatment (DRT) and the rate of weight gain (RWG) in severely malnourished children remains inconclusive. Objectives. To determine whether the RWG and DRT differ by baseline clinical characteristics, and to assess the effect of HIV status and disease stage on the relationship between these two clinical outcomes. Methods. This was a retrospective record review of 346 patiens discharged between 2009 and 2013 following treatment for severe acute malnutrition (SAM) at two rural hospitals in South Africa. Results. A third of the sample was HIV-positive, the RWG (measured as g/kg/day) was significantly slower in HIV-positive patients compared with HIV-negative cases (mean 5.2, 95% confidence interval (CI) 4.47 - 5.93 v. mean 8.51; CI 7.98 - 9.05; p<0.0001) and cases at stage IV of HIV infection had a significantly slower RWG (mean 3.97; CI 2.33 - 5.61) compared with those at stages I (mean 7.64; CI 6.21 - 9.07) (p<0.0001) and II (mean 5.87; CI 4.74 - 6.99). The mean DRT was longer in HIV-positive cases and those at advanced stages of HIV infection. HIV-positive cases were renourished and treated for almost 3.5 times longer than their HIV-negative counterparts to achieve a moderate RWG (5 - 10 g/kg/day). Conclusion. This study highlights the need to reconsider energy requirements for HIV-positive cases at different clinical stages, for more rapid nutritional recovery in under-resourced settings where prolonged hospitalisation may be a challenge.http://www.sajch.org.za/index.php/SAJCH/article/view/1374/775 |
| spellingShingle | Moïse Muzigaba Benn Sartorius Thandi Puoane Brian Van Wyk David Sanders The impact of HIV infection and disease stage on the rate of weight gain and duration of refeeding and treatment in severely malnourished children in rural South African hospitals South African Journal of Child Health |
| title | The impact of HIV infection and disease stage on the rate of weight gain and duration of refeeding and treatment in severely malnourished children in rural South African hospitals |
| title_full | The impact of HIV infection and disease stage on the rate of weight gain and duration of refeeding and treatment in severely malnourished children in rural South African hospitals |
| title_fullStr | The impact of HIV infection and disease stage on the rate of weight gain and duration of refeeding and treatment in severely malnourished children in rural South African hospitals |
| title_full_unstemmed | The impact of HIV infection and disease stage on the rate of weight gain and duration of refeeding and treatment in severely malnourished children in rural South African hospitals |
| title_short | The impact of HIV infection and disease stage on the rate of weight gain and duration of refeeding and treatment in severely malnourished children in rural South African hospitals |
| title_sort | impact of hiv infection and disease stage on the rate of weight gain and duration of refeeding and treatment in severely malnourished children in rural south african hospitals |
| url | http://www.sajch.org.za/index.php/SAJCH/article/view/1374/775 |
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