Left Atrial Strain Identifies Increased Atrial Ectopy in Patients with Beta-Thalassemia Major
Patients with beta-thalassemia major (β-ΤΜ) may develop cardiac arrhythmias through a multifactorial mechanism. The current study evaluated the association of cardiac structure and function on echocardiography with atrial ectopic burden on 24-hour tape recording in β-ΤΜ patients. This prospective st...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/1/1 |
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| author | Maria Vlachou Vasileios Kamperidis Efthymia Vlachaki Georgios Tziatzios Despoina Pantelidou Afroditi Boutou Chrysa Apostolou Despoina Papadopoulou George Giannakoulas Haralambos Karvounis |
| author_facet | Maria Vlachou Vasileios Kamperidis Efthymia Vlachaki Georgios Tziatzios Despoina Pantelidou Afroditi Boutou Chrysa Apostolou Despoina Papadopoulou George Giannakoulas Haralambos Karvounis |
| author_sort | Maria Vlachou |
| collection | DOAJ |
| description | Patients with beta-thalassemia major (β-ΤΜ) may develop cardiac arrhythmias through a multifactorial mechanism. The current study evaluated the association of cardiac structure and function on echocardiography with atrial ectopic burden on 24-hour tape recording in β-ΤΜ patients. This prospective study included consecutive β-ΤΜ patients. Demographic, laboratory, echocardiographic, cardiac magnetic resonance (CMR) T2* and 24-hour tape recording data were prospectively collected. The patients were classified according to the median value of premature atrial contractions (PACs) on 24-hour tape. In total, 50 β-TM patients (37.6 ± 9.1 years old, 50% male) were divided in 2 groups; PACs ≤ 24/day and > 24/day. Patients with PACs > 24/day were treated with blood transfusion for a longer period of time (39.0 ± 8.6 vs. 32.0 ± 8.9 years, <i>p</i> < 0.007), compared to their counterparts. Older age (OR: 1.121, 95% CI: 1.032–1.217, <i>p</i> = 0.007), longer duration of blood transfusion (OR:1.101, 95% CI:1.019–1.188, <i>p</i> = 0.014), larger LV end-diastolic diameter (OR: 4.522, 95% CI:1.009–20.280, <i>p</i> = 0.049), higher values of LA peak systolic strain (OR: 0.869, 95% CI: 0.783–0.964, <i>p</i> = 0.008), higher MV E/E′ average (OR: 1.407, 95% CI: 1.028–1.926, <i>p</i> = 0.033) and higher right ventricular systolic pressure (OR: 1.147, 95% CI: 1.039–1.266, <i>p</i> = 0.006) were univariably associated with PACs > 24/day. LA peak systolic strain remained significantly associated with PACs > 24/day after adjusting for the duration of blood transfusions or for CMR T2*. The multivariable model including blood transfusion duration and LA peak systolic strain was the most closely associated with PACs > 24/day. Receiver operating characteristic curve analysis identified a left atrial peak systolic strain of 31.5%, as the best cut-off value (83% sensitivity, 68% specificity) for prediction of PACs > 24/day. In β-TM patients, LA peak systolic strain was associated with the atrial arrhythmia burden independently to the duration of blood transfusions and CMR T2*. |
| first_indexed | 2024-04-12T22:39:09Z |
| format | Article |
| id | doaj.art-499f6f76535c48c79de08df5823568d0 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-12T22:39:09Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-499f6f76535c48c79de08df5823568d02022-12-22T03:13:46ZengMDPI AGDiagnostics2075-44182020-12-01111110.3390/diagnostics11010001Left Atrial Strain Identifies Increased Atrial Ectopy in Patients with Beta-Thalassemia MajorMaria Vlachou0Vasileios Kamperidis1Efthymia Vlachaki2Georgios Tziatzios3Despoina Pantelidou4Afroditi Boutou5Chrysa Apostolou6Despoina Papadopoulou7George Giannakoulas8Haralambos Karvounis91st Cardiology Department, AHEPA Hospital, Aristotle University of Thessaloniki, Stilponos Kyriakidi 1, 54621 Thessaloniki, Greece1st Cardiology Department, AHEPA Hospital, Aristotle University of Thessaloniki, Stilponos Kyriakidi 1, 54621 Thessaloniki, GreeceThalassaemia Unit, Ippokratio University Hospital, 54642 Thessaloniki, Greece1st Cardiology Department, AHEPA Hospital, Aristotle University of Thessaloniki, Stilponos Kyriakidi 1, 54621 Thessaloniki, GreeceThalassaemia Unit, AHEPA University Hospital, 54621 Thessaloniki, GreecePulmonary Department, Papanikolaou Hospital, 57010 Thessaloniki, GreeceThalassaemia Unit, Ippokratio University Hospital, 54642 Thessaloniki, GreeceThalassaemia Unit, AHEPA University Hospital, 54621 Thessaloniki, Greece1st Cardiology Department, AHEPA Hospital, Aristotle University of Thessaloniki, Stilponos Kyriakidi 1, 54621 Thessaloniki, Greece1st Cardiology Department, AHEPA Hospital, Aristotle University of Thessaloniki, Stilponos Kyriakidi 1, 54621 Thessaloniki, GreecePatients with beta-thalassemia major (β-ΤΜ) may develop cardiac arrhythmias through a multifactorial mechanism. The current study evaluated the association of cardiac structure and function on echocardiography with atrial ectopic burden on 24-hour tape recording in β-ΤΜ patients. This prospective study included consecutive β-ΤΜ patients. Demographic, laboratory, echocardiographic, cardiac magnetic resonance (CMR) T2* and 24-hour tape recording data were prospectively collected. The patients were classified according to the median value of premature atrial contractions (PACs) on 24-hour tape. In total, 50 β-TM patients (37.6 ± 9.1 years old, 50% male) were divided in 2 groups; PACs ≤ 24/day and > 24/day. Patients with PACs > 24/day were treated with blood transfusion for a longer period of time (39.0 ± 8.6 vs. 32.0 ± 8.9 years, <i>p</i> < 0.007), compared to their counterparts. Older age (OR: 1.121, 95% CI: 1.032–1.217, <i>p</i> = 0.007), longer duration of blood transfusion (OR:1.101, 95% CI:1.019–1.188, <i>p</i> = 0.014), larger LV end-diastolic diameter (OR: 4.522, 95% CI:1.009–20.280, <i>p</i> = 0.049), higher values of LA peak systolic strain (OR: 0.869, 95% CI: 0.783–0.964, <i>p</i> = 0.008), higher MV E/E′ average (OR: 1.407, 95% CI: 1.028–1.926, <i>p</i> = 0.033) and higher right ventricular systolic pressure (OR: 1.147, 95% CI: 1.039–1.266, <i>p</i> = 0.006) were univariably associated with PACs > 24/day. LA peak systolic strain remained significantly associated with PACs > 24/day after adjusting for the duration of blood transfusions or for CMR T2*. The multivariable model including blood transfusion duration and LA peak systolic strain was the most closely associated with PACs > 24/day. Receiver operating characteristic curve analysis identified a left atrial peak systolic strain of 31.5%, as the best cut-off value (83% sensitivity, 68% specificity) for prediction of PACs > 24/day. In β-TM patients, LA peak systolic strain was associated with the atrial arrhythmia burden independently to the duration of blood transfusions and CMR T2*.https://www.mdpi.com/2075-4418/11/1/1beta-thalassemia majorarrhythmiapremature atrial contractionsleft atrial strain |
| spellingShingle | Maria Vlachou Vasileios Kamperidis Efthymia Vlachaki Georgios Tziatzios Despoina Pantelidou Afroditi Boutou Chrysa Apostolou Despoina Papadopoulou George Giannakoulas Haralambos Karvounis Left Atrial Strain Identifies Increased Atrial Ectopy in Patients with Beta-Thalassemia Major Diagnostics beta-thalassemia major arrhythmia premature atrial contractions left atrial strain |
| title | Left Atrial Strain Identifies Increased Atrial Ectopy in Patients with Beta-Thalassemia Major |
| title_full | Left Atrial Strain Identifies Increased Atrial Ectopy in Patients with Beta-Thalassemia Major |
| title_fullStr | Left Atrial Strain Identifies Increased Atrial Ectopy in Patients with Beta-Thalassemia Major |
| title_full_unstemmed | Left Atrial Strain Identifies Increased Atrial Ectopy in Patients with Beta-Thalassemia Major |
| title_short | Left Atrial Strain Identifies Increased Atrial Ectopy in Patients with Beta-Thalassemia Major |
| title_sort | left atrial strain identifies increased atrial ectopy in patients with beta thalassemia major |
| topic | beta-thalassemia major arrhythmia premature atrial contractions left atrial strain |
| url | https://www.mdpi.com/2075-4418/11/1/1 |
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