Pretreatment of Crude Pancreatic Islets with Mitomycin C (Mmc) Prolongs Islet Graft Survival in a Xenogeneic Rat-To-Mouse Model

Pretreatment of Crude Pancreatic Islets with Mitomycin C (Mmc) Prolongs Islet Graft Survival in a Xenogeneic Rat-To-Mouse Model

In this study, we examined the effect of mitomycin C (MMC) treatment on graft survival and evaluated its efficacy in immunomodulation of islet graft for transplantation. Male WS rats were used as islet donors and streptozotocin-induced diabetic C57BL/6 mice as recipients. The isolated islets were tr...

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Main Authors: Tadeusz Grochowiecki, Mitsukazu Gotoh, Keizo Dono, Yutaka Takeda, Masayoshi Nishihara, Yoshihiko Ohta, Fumihiko Kimura, Hiroki Ohzato, Koji Umeshita, Masato Sakon, Morito Monden
Format: Article
Language:English
Published: SAGE Publishing 1998-07-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/096368979800700411

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