Validity and reliability of the Patient-Reported Arthralgia Inventory: validation of a newly-developed survey instrument to measure arthralgia
Liana D Castel,1 Kenneth A Wallston,2 Benjamin R Saville,3 JoAnn R Alvarez,3 Bradley D Shields,4 Irene D Feurer,3 David Cella5 1Meharry-Vanderbilt Alliance, Nashville, TN, USA; 2Psychology in Nursing, Vanderbilt University School of Nursing, Nashville, TN, USA; 3Surgery and Biostatistics, Vanderbilt...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2015-07-01
|
| Series: | Patient Related Outcome Measures |
| Online Access: | http://www.dovepress.com/validity-and-reliability-of-the-patient-reported-arthralgia-inventory--peer-reviewed-article-PROM |
| _version_ | 1818107942507905024 |
|---|---|
| author | Castel LD Wallston KA Saville BR Alvarez JR Shields BD Feurer ID Cella DF |
| author_facet | Castel LD Wallston KA Saville BR Alvarez JR Shields BD Feurer ID Cella DF |
| author_sort | Castel LD |
| collection | DOAJ |
| description | Liana D Castel,1 Kenneth A Wallston,2 Benjamin R Saville,3 JoAnn R Alvarez,3 Bradley D Shields,4 Irene D Feurer,3 David Cella5 1Meharry-Vanderbilt Alliance, Nashville, TN, USA; 2Psychology in Nursing, Vanderbilt University School of Nursing, Nashville, TN, USA; 3Surgery and Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA; 4Medical Sciences, University of Arkansas School of Medicine, Little Rock, AR, USA; 5Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Background: There is a need for a survey instrument to measure arthralgia (joint pain) that has been psychometrically validated in the context of existing reference instruments. We developed the 16-item Patient-Reported Arthralgia Inventory (PRAI) to measure arthralgia severity in 16 joints, in the context of a longitudinal cohort study to assess aromatase inhibitor-associated arthralgia in breast cancer survivors and arthralgia in postmenopausal women without breast cancer. We sought to evaluate the reliability and validity of the PRAI instrument in these populations, as well as to examine the relationship of patient-reported morning stiffness and arthralgia. Methods: We administered the PRAI on paper in 294 women (94 initiating aromatase inhibitor therapy and 200 postmenopausal women without breast cancer) at weeks 0, 2, 4, 6, 8, 12, 16, and 52, as well as once in 36 women who had taken but were no longer taking aromatase inhibitor therapy. Results: Cronbach's alpha was 0.9 for internal consistency of the PRAI. Intraclass correlation coefficients of test-retest reliability were in the range of 0.87–0.96 over repeated PRAI administrations; arthralgia severity was higher in the non-cancer group at baseline than at subsequent assessments. Women with joint comorbidities tended to have higher PRAI scores than those without (estimated difference in mean scores: -0.3, 95% confidence interval [CI] -0.5, -0.2; P<0.001). The PRAI was highly correlated with the Functional Assessment of Cancer Therapy-Endocrine Subscale item “I have pain in my joints” (reference instrument; Spearman r range: 0.76–0.82). Greater arthralgia severity on the PRAI was also related to decreased physical function (r=-0.47, 95% CI -0.55, -0.37; P<0.001), higher pain interference (r=0.65, 95% CI 0.57–0.72; P<0.001), less active performance status (estimated difference in location (-0.6, 95% CI -0.9, -0.4; P<0.001), and increased morning stiffness duration (r=0.62, 95% CI 0.54–0.69; P<0.0001). Conclusion: We conclude that the psychometric properties of the PRAI are satisfactory for measuring arthralgia severity. Keywords: arthralgia, joint pain, pain measurement, validation studies, questionnaire design, aromatase inhibitors, postmenopause |
| first_indexed | 2024-12-11T02:07:29Z |
| format | Article |
| id | doaj.art-49a204c4089448028d2edecdd9390283 |
| institution | Directory Open Access Journal |
| issn | 1179-271X |
| language | English |
| last_indexed | 2024-12-11T02:07:29Z |
| publishDate | 2015-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Related Outcome Measures |
| spelling | doaj.art-49a204c4089448028d2edecdd93902832022-12-22T01:24:20ZengDove Medical PressPatient Related Outcome Measures1179-271X2015-07-012015default20521422824Validity and reliability of the Patient-Reported Arthralgia Inventory: validation of a newly-developed survey instrument to measure arthralgiaCastel LDWallston KASaville BRAlvarez JRShields BDFeurer IDCella DFLiana D Castel,1 Kenneth A Wallston,2 Benjamin R Saville,3 JoAnn R Alvarez,3 Bradley D Shields,4 Irene D Feurer,3 David Cella5 1Meharry-Vanderbilt Alliance, Nashville, TN, USA; 2Psychology in Nursing, Vanderbilt University School of Nursing, Nashville, TN, USA; 3Surgery and Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA; 4Medical Sciences, University of Arkansas School of Medicine, Little Rock, AR, USA; 5Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Background: There is a need for a survey instrument to measure arthralgia (joint pain) that has been psychometrically validated in the context of existing reference instruments. We developed the 16-item Patient-Reported Arthralgia Inventory (PRAI) to measure arthralgia severity in 16 joints, in the context of a longitudinal cohort study to assess aromatase inhibitor-associated arthralgia in breast cancer survivors and arthralgia in postmenopausal women without breast cancer. We sought to evaluate the reliability and validity of the PRAI instrument in these populations, as well as to examine the relationship of patient-reported morning stiffness and arthralgia. Methods: We administered the PRAI on paper in 294 women (94 initiating aromatase inhibitor therapy and 200 postmenopausal women without breast cancer) at weeks 0, 2, 4, 6, 8, 12, 16, and 52, as well as once in 36 women who had taken but were no longer taking aromatase inhibitor therapy. Results: Cronbach's alpha was 0.9 for internal consistency of the PRAI. Intraclass correlation coefficients of test-retest reliability were in the range of 0.87–0.96 over repeated PRAI administrations; arthralgia severity was higher in the non-cancer group at baseline than at subsequent assessments. Women with joint comorbidities tended to have higher PRAI scores than those without (estimated difference in mean scores: -0.3, 95% confidence interval [CI] -0.5, -0.2; P<0.001). The PRAI was highly correlated with the Functional Assessment of Cancer Therapy-Endocrine Subscale item “I have pain in my joints” (reference instrument; Spearman r range: 0.76–0.82). Greater arthralgia severity on the PRAI was also related to decreased physical function (r=-0.47, 95% CI -0.55, -0.37; P<0.001), higher pain interference (r=0.65, 95% CI 0.57–0.72; P<0.001), less active performance status (estimated difference in location (-0.6, 95% CI -0.9, -0.4; P<0.001), and increased morning stiffness duration (r=0.62, 95% CI 0.54–0.69; P<0.0001). Conclusion: We conclude that the psychometric properties of the PRAI are satisfactory for measuring arthralgia severity. Keywords: arthralgia, joint pain, pain measurement, validation studies, questionnaire design, aromatase inhibitors, postmenopausehttp://www.dovepress.com/validity-and-reliability-of-the-patient-reported-arthralgia-inventory--peer-reviewed-article-PROM |
| spellingShingle | Castel LD Wallston KA Saville BR Alvarez JR Shields BD Feurer ID Cella DF Validity and reliability of the Patient-Reported Arthralgia Inventory: validation of a newly-developed survey instrument to measure arthralgia Patient Related Outcome Measures |
| title | Validity and reliability of the Patient-Reported Arthralgia Inventory: validation of a newly-developed survey instrument to measure arthralgia |
| title_full | Validity and reliability of the Patient-Reported Arthralgia Inventory: validation of a newly-developed survey instrument to measure arthralgia |
| title_fullStr | Validity and reliability of the Patient-Reported Arthralgia Inventory: validation of a newly-developed survey instrument to measure arthralgia |
| title_full_unstemmed | Validity and reliability of the Patient-Reported Arthralgia Inventory: validation of a newly-developed survey instrument to measure arthralgia |
| title_short | Validity and reliability of the Patient-Reported Arthralgia Inventory: validation of a newly-developed survey instrument to measure arthralgia |
| title_sort | validity and reliability of the patient reported arthralgia inventory validation of a newly developed survey instrument to measure arthralgia |
| url | http://www.dovepress.com/validity-and-reliability-of-the-patient-reported-arthralgia-inventory--peer-reviewed-article-PROM |
| work_keys_str_mv | AT castelld validityandreliabilityofthepatientreportedarthralgiainventoryvalidationofanewlydevelopedsurveyinstrumenttomeasurearthralgia AT wallstonka validityandreliabilityofthepatientreportedarthralgiainventoryvalidationofanewlydevelopedsurveyinstrumenttomeasurearthralgia AT savillebr validityandreliabilityofthepatientreportedarthralgiainventoryvalidationofanewlydevelopedsurveyinstrumenttomeasurearthralgia AT alvarezjr validityandreliabilityofthepatientreportedarthralgiainventoryvalidationofanewlydevelopedsurveyinstrumenttomeasurearthralgia AT shieldsbd validityandreliabilityofthepatientreportedarthralgiainventoryvalidationofanewlydevelopedsurveyinstrumenttomeasurearthralgia AT feurerid validityandreliabilityofthepatientreportedarthralgiainventoryvalidationofanewlydevelopedsurveyinstrumenttomeasurearthralgia AT celladf validityandreliabilityofthepatientreportedarthralgiainventoryvalidationofanewlydevelopedsurveyinstrumenttomeasurearthralgia |