EFFECT OF α-TOCOTRIENOL AND PROXISOME PROLIFRATIVE-ACTIVATED RECEPTOR LIGAND ON THE BRAIN ISCHEMIA IN MALE RAT
BACKGROUND AND OBJECTIVE: Stroke is one of the leading causes of death and disability in the world. Previous studies have demonstrated that α-tocotrienol (α-TCT) and rosiglitazone (RGZ) reduce ischemic damage by middle cerebral artery (MCA) occlusion when administered before ischemic stroke in mice...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2008-08-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
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| Online Access: | http://jbums.org/article-1-2465-en.html |
| _version_ | 1818985388190990336 |
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| author | MA Allahtavakoli A Shamsizadeh M Mahmoodi, R Moloudi, ME Rezvani |
| author_facet | MA Allahtavakoli A Shamsizadeh M Mahmoodi, R Moloudi, ME Rezvani |
| author_sort | MA Allahtavakoli |
| collection | DOAJ |
| description | BACKGROUND AND OBJECTIVE: Stroke is one of the leading causes of death and disability in the world. Previous studies have demonstrated that α-tocotrienol (α-TCT) and rosiglitazone (RGZ) reduce ischemic damage by middle cerebral artery (MCA) occlusion when administered before ischemic stroke in mice and rats. The aim of this study was to investigate the neuroprotective effects of α-TCT and RGZ at 3 hours after cerebral ischemia. METHODS: In this experimental study, stroke was induced by embolizing a preformed clot into the MCA. Male Wistar rats (300-350 gr) were assigned to α-TCT (1 or 10 mg/kg), rosiglitazone (RGZ) and sham-operation. The drugs were injected i.p. Stained brain sections were scanned and infarct area were determined using a picture analyzer software. FINDINGS: Forty eight hours after embolic ischemia, infarct volume in the control, RGZ, low and high doses of α-TCT were 29.4±2.6%, 15.9±3.1%, 24.9±2.1% and 29±4.8%, respectively. There was a significant difference between control and RGZ groups (p<0.05). Compared to the control group, the low and high doses of α-TCT didn’t show any significant difference. Furthermore, only RGZ decreased neurological deficits (p<0.05) and sensory impairments (p<0.01). CONCLUSION: Administration of α-TCT at 3 hr after induction of cerebral ischemia is not neuroprotective but RGZ may have beneficial effects on treatment and management of stroke. So further studies are needed to survey the neuroprotective effects of α-TCT after stroke. |
| first_indexed | 2024-12-20T18:34:06Z |
| format | Article |
| id | doaj.art-49a63bd667664ece8c48bf56eb084b0e |
| institution | Directory Open Access Journal |
| issn | 1561-4107 2251-7170 |
| language | English |
| last_indexed | 2024-12-20T18:34:06Z |
| publishDate | 2008-08-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj.art-49a63bd667664ece8c48bf56eb084b0e2022-12-21T19:29:57ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702008-08-01103714EFFECT OF α-TOCOTRIENOL AND PROXISOME PROLIFRATIVE-ACTIVATED RECEPTOR LIGAND ON THE BRAIN ISCHEMIA IN MALE RATMA Allahtavakoli0A Shamsizadeh1M Mahmoodi,2R Moloudi,3ME Rezvani4 BACKGROUND AND OBJECTIVE: Stroke is one of the leading causes of death and disability in the world. Previous studies have demonstrated that α-tocotrienol (α-TCT) and rosiglitazone (RGZ) reduce ischemic damage by middle cerebral artery (MCA) occlusion when administered before ischemic stroke in mice and rats. The aim of this study was to investigate the neuroprotective effects of α-TCT and RGZ at 3 hours after cerebral ischemia. METHODS: In this experimental study, stroke was induced by embolizing a preformed clot into the MCA. Male Wistar rats (300-350 gr) were assigned to α-TCT (1 or 10 mg/kg), rosiglitazone (RGZ) and sham-operation. The drugs were injected i.p. Stained brain sections were scanned and infarct area were determined using a picture analyzer software. FINDINGS: Forty eight hours after embolic ischemia, infarct volume in the control, RGZ, low and high doses of α-TCT were 29.4±2.6%, 15.9±3.1%, 24.9±2.1% and 29±4.8%, respectively. There was a significant difference between control and RGZ groups (p<0.05). Compared to the control group, the low and high doses of α-TCT didn’t show any significant difference. Furthermore, only RGZ decreased neurological deficits (p<0.05) and sensory impairments (p<0.01). CONCLUSION: Administration of α-TCT at 3 hr after induction of cerebral ischemia is not neuroprotective but RGZ may have beneficial effects on treatment and management of stroke. So further studies are needed to survey the neuroprotective effects of α-TCT after stroke.http://jbums.org/article-1-2465-en.htmlcerebral ischemiaembolic modelα-tocotrienolvitamin eneuroprotection |
| spellingShingle | MA Allahtavakoli A Shamsizadeh M Mahmoodi, R Moloudi, ME Rezvani EFFECT OF α-TOCOTRIENOL AND PROXISOME PROLIFRATIVE-ACTIVATED RECEPTOR LIGAND ON THE BRAIN ISCHEMIA IN MALE RAT Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul cerebral ischemia embolic model α-tocotrienol vitamin e neuroprotection |
| title | EFFECT OF α-TOCOTRIENOL AND PROXISOME PROLIFRATIVE-ACTIVATED RECEPTOR LIGAND ON THE BRAIN ISCHEMIA IN MALE RAT |
| title_full | EFFECT OF α-TOCOTRIENOL AND PROXISOME PROLIFRATIVE-ACTIVATED RECEPTOR LIGAND ON THE BRAIN ISCHEMIA IN MALE RAT |
| title_fullStr | EFFECT OF α-TOCOTRIENOL AND PROXISOME PROLIFRATIVE-ACTIVATED RECEPTOR LIGAND ON THE BRAIN ISCHEMIA IN MALE RAT |
| title_full_unstemmed | EFFECT OF α-TOCOTRIENOL AND PROXISOME PROLIFRATIVE-ACTIVATED RECEPTOR LIGAND ON THE BRAIN ISCHEMIA IN MALE RAT |
| title_short | EFFECT OF α-TOCOTRIENOL AND PROXISOME PROLIFRATIVE-ACTIVATED RECEPTOR LIGAND ON THE BRAIN ISCHEMIA IN MALE RAT |
| title_sort | effect of α tocotrienol and proxisome prolifrative activated receptor ligand on the brain ischemia in male rat |
| topic | cerebral ischemia embolic model α-tocotrienol vitamin e neuroprotection |
| url | http://jbums.org/article-1-2465-en.html |
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