Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcoma
Cancer is one of the leading health concerns for human and animal health. Since the tumorigenesis process is not completely understood and it is known that some viruses can induce carcinogenesis, it is highly important to identify novel oncoviruses and extensively study underlying oncogenic mechanis...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-12-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00655/full |
| _version_ | 1818974388325711872 |
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| author | Marta eCanuti Marta eCanuti Cathy V. Williams Sashi Rekha Gadi Maarten F. Jebbink Bas B. Oude Munnink Seyed Mohammad eJazaeri Farsani John eCullen Lia eVan Der Hoek |
| author_facet | Marta eCanuti Marta eCanuti Cathy V. Williams Sashi Rekha Gadi Maarten F. Jebbink Bas B. Oude Munnink Seyed Mohammad eJazaeri Farsani John eCullen Lia eVan Der Hoek |
| author_sort | Marta eCanuti |
| collection | DOAJ |
| description | Cancer is one of the leading health concerns for human and animal health. Since the tumorigenesis process is not completely understood and it is known that some viruses can induce carcinogenesis, it is highly important to identify novel oncoviruses and extensively study underlying oncogenic mechanisms. Here, we investigated a case of diffuse histiocytic sarcoma in a 22 years old slow loris (Nycticebus coucang), using a broad spectrum virus discovery technique. A novel parvovirus was discovered and the phylogenetic analysis performed on its fully sequenced genome demonstrated that it represents the first member of a novel genus. The possible causative correlation between this virus and the malignancy was further investigated and 20 serum and 61 organ samples from 25 animals (N. coucang and N. pygmaeus) were screened for the novel virus but only samples collected from the originally infected animal were positive. The virus was present in all tested organs (intestine, liver, spleen, kidneys and lungs) and in all banked serum samples collected up to 8 years before death. All attempts to identify a latent viral form (integrated or episomal) were unsuccessful and the increase of variation in the viral sequences during the years was consistent with absence of latency. Since it is well known that parvoviruses are dependent on cell division to successfully replicate, we hypothesized that the virus could have benefitted from the constantly dividing cancer cells and may not have been the cause of the histiocytic sarcoma. It is also possible to conjecture that the virus had a role in delaying the tumor progression and this report might bring new exciting opportunities in recognizing viruses to be used in cancer virotherapy. |
| first_indexed | 2024-12-20T15:39:16Z |
| format | Article |
| id | doaj.art-49a65573ea1246f2aef741817a58ccb9 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-20T15:39:16Z |
| publishDate | 2014-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-49a65573ea1246f2aef741817a58ccb92022-12-21T19:35:15ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2014-12-01510.3389/fmicb.2014.00655123161Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcomaMarta eCanuti0Marta eCanuti1Cathy V. Williams2Sashi Rekha Gadi3Maarten F. Jebbink4Bas B. Oude Munnink5Seyed Mohammad eJazaeri Farsani6John eCullen7Lia eVan Der Hoek8Academic Medical Center, University of AmsterdamMemorial University of NewfoundlandDuke UniversityNorth Carolina State UniversityAcademic Medical Center, University of AmsterdamAcademic Medical Center, University of AmsterdamAcademic Medical Center, University of AmsterdamNorth Carolina State UniversityAcademic Medical Center, University of AmsterdamCancer is one of the leading health concerns for human and animal health. Since the tumorigenesis process is not completely understood and it is known that some viruses can induce carcinogenesis, it is highly important to identify novel oncoviruses and extensively study underlying oncogenic mechanisms. Here, we investigated a case of diffuse histiocytic sarcoma in a 22 years old slow loris (Nycticebus coucang), using a broad spectrum virus discovery technique. A novel parvovirus was discovered and the phylogenetic analysis performed on its fully sequenced genome demonstrated that it represents the first member of a novel genus. The possible causative correlation between this virus and the malignancy was further investigated and 20 serum and 61 organ samples from 25 animals (N. coucang and N. pygmaeus) were screened for the novel virus but only samples collected from the originally infected animal were positive. The virus was present in all tested organs (intestine, liver, spleen, kidneys and lungs) and in all banked serum samples collected up to 8 years before death. All attempts to identify a latent viral form (integrated or episomal) were unsuccessful and the increase of variation in the viral sequences during the years was consistent with absence of latency. Since it is well known that parvoviruses are dependent on cell division to successfully replicate, we hypothesized that the virus could have benefitted from the constantly dividing cancer cells and may not have been the cause of the histiocytic sarcoma. It is also possible to conjecture that the virus had a role in delaying the tumor progression and this report might bring new exciting opportunities in recognizing viruses to be used in cancer virotherapy.http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00655/fullHistiocytic SarcomaParvovirusvirus discoveryVIDISCAOncovirusSlow loris |
| spellingShingle | Marta eCanuti Marta eCanuti Cathy V. Williams Sashi Rekha Gadi Maarten F. Jebbink Bas B. Oude Munnink Seyed Mohammad eJazaeri Farsani John eCullen Lia eVan Der Hoek Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcoma Frontiers in Microbiology Histiocytic Sarcoma Parvovirus virus discovery VIDISCA Oncovirus Slow loris |
| title | Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcoma |
| title_full | Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcoma |
| title_fullStr | Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcoma |
| title_full_unstemmed | Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcoma |
| title_short | Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcoma |
| title_sort | persistent viremia by a novel parvovirus in a slow loris nycticebus coucang with diffuse histiocytic sarcoma |
| topic | Histiocytic Sarcoma Parvovirus virus discovery VIDISCA Oncovirus Slow loris |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00655/full |
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