Emerging Noninvasive Biomarkers, and Medical Management Strategies for Alcoholic Hepatitis: Present Understanding and Scope
Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/3/524 |
| _version_ | 1797708315972599808 |
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| author | Khushboo S. Gala Vatsalya Vatsalya |
| author_facet | Khushboo S. Gala Vatsalya Vatsalya |
| author_sort | Khushboo S. Gala |
| collection | DOAJ |
| description | Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and biomarkers of alcoholic liver disease (ALD). No ideal biomarker has been identified to quantify the degree of hepatocyte death or severity of AH, even though numerous biomarkers have been associated with AH. This review provides information of some of the novel and latest biomarkers that are being investigated and have shown a substantial association with the degree and severity of liver injury and inflammation. Importantly, they can be measured noninvasively. In this manuscript, we consolidate the present understanding and prospects of these biomarkers; and their application in assessing the severity and progression of the alcoholic liver disease (ALD). We also review current and upcoming management options for AH. |
| first_indexed | 2024-03-12T06:19:35Z |
| format | Article |
| id | doaj.art-49a7e270d2694a7c8d002ce292100563 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:19:35Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-49a7e270d2694a7c8d002ce2921005632023-09-03T02:16:44ZengMDPI AGCells2073-44092020-02-019352410.3390/cells9030524cells9030524Emerging Noninvasive Biomarkers, and Medical Management Strategies for Alcoholic Hepatitis: Present Understanding and ScopeKhushboo S. Gala0Vatsalya Vatsalya1Division of Internal Medicine, University of Louisville, Louisville, KY 40202; USADivision of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, KY 40202, USAAlcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and biomarkers of alcoholic liver disease (ALD). No ideal biomarker has been identified to quantify the degree of hepatocyte death or severity of AH, even though numerous biomarkers have been associated with AH. This review provides information of some of the novel and latest biomarkers that are being investigated and have shown a substantial association with the degree and severity of liver injury and inflammation. Importantly, they can be measured noninvasively. In this manuscript, we consolidate the present understanding and prospects of these biomarkers; and their application in assessing the severity and progression of the alcoholic liver disease (ALD). We also review current and upcoming management options for AH.https://www.mdpi.com/2073-4409/9/3/524alcoholnovel biomarkersmedical managementalcoholic hepatitisnoninvasive biomarkersalcoholic liver disease |
| spellingShingle | Khushboo S. Gala Vatsalya Vatsalya Emerging Noninvasive Biomarkers, and Medical Management Strategies for Alcoholic Hepatitis: Present Understanding and Scope Cells alcohol novel biomarkers medical management alcoholic hepatitis noninvasive biomarkers alcoholic liver disease |
| title | Emerging Noninvasive Biomarkers, and Medical Management Strategies for Alcoholic Hepatitis: Present Understanding and Scope |
| title_full | Emerging Noninvasive Biomarkers, and Medical Management Strategies for Alcoholic Hepatitis: Present Understanding and Scope |
| title_fullStr | Emerging Noninvasive Biomarkers, and Medical Management Strategies for Alcoholic Hepatitis: Present Understanding and Scope |
| title_full_unstemmed | Emerging Noninvasive Biomarkers, and Medical Management Strategies for Alcoholic Hepatitis: Present Understanding and Scope |
| title_short | Emerging Noninvasive Biomarkers, and Medical Management Strategies for Alcoholic Hepatitis: Present Understanding and Scope |
| title_sort | emerging noninvasive biomarkers and medical management strategies for alcoholic hepatitis present understanding and scope |
| topic | alcohol novel biomarkers medical management alcoholic hepatitis noninvasive biomarkers alcoholic liver disease |
| url | https://www.mdpi.com/2073-4409/9/3/524 |
| work_keys_str_mv | AT khushboosgala emergingnoninvasivebiomarkersandmedicalmanagementstrategiesforalcoholichepatitispresentunderstandingandscope AT vatsalyavatsalya emergingnoninvasivebiomarkersandmedicalmanagementstrategiesforalcoholichepatitispresentunderstandingandscope |