Change in brainstem gray matter concentration following a mindfulness-based intervention is correlated with improvement in psychological well-being
<br/>Individuals can improve their levels of psychological well-being through utilization of psychological interventions, including the practice of mindfulness meditation, which is defined as the non-judgmental awareness of experiences in the present moment. We recently reported that an 8-week...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-02-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00033/full |
| _version_ | 1818035893626208256 |
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| author | Sara eLazar |
| author_facet | Sara eLazar |
| author_sort | Sara eLazar |
| collection | DOAJ |
| description | <br/>Individuals can improve their levels of psychological well-being through utilization of psychological interventions, including the practice of mindfulness meditation, which is defined as the non-judgmental awareness of experiences in the present moment. We recently reported that an 8-week Mindfulness-Based Stress Reduction (MBSR) course lead to increases in gray matter concentration in several brain areas, as detected with voxel-based morphometry of MPRAGE MRI scans, including the pons/raphe/locus coeruleus area of the brainstem. Given the role of the pons and raphe in mood and arousal, we hypothesized that changes in this region might underlie changes in well-being.<br/>A subset of fourteen healthy individuals from a previously published data set completed anatomical MRI and filled out the Psychological Well-Being (PWB) scale before and after MBSR participation. PWB change was used as the predictive regressor for changes in gray matter density within those brain regions that had previously shown pre- to post- MBSR changes. Results showed that scores on five PWB subscales as well as the PWB total score increased significantly over the MBSR course. The change was positively correlated with gray matter concentration increases in two symmetrically bilateral clusters in the brainstem. Those clusters appeared to contain the area of the pontine tegmentum, locus coeruleus, nucleus raphe pontis, and the sensory trigeminal nucleus. No clusters were negatively correlated with the change in PWB. This preliminary study suggests a neural correlate of enhanced psychological well-being. The identified brain areas include the sites of synthesis and release of the neurotransmitters norepinephrine and serotonin, which are involved in the modulation of arousal and mood, and have been related to a variety of affective functions as well as associated clinical dysfunctions. |
| first_indexed | 2024-12-10T07:02:18Z |
| format | Article |
| id | doaj.art-49a8f5b68aa94e56b121d7ad1b0a4e1c |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-10T07:02:18Z |
| publishDate | 2014-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-49a8f5b68aa94e56b121d7ad1b0a4e1c2022-12-22T01:58:16ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612014-02-01810.3389/fnhum.2014.0003359739Change in brainstem gray matter concentration following a mindfulness-based intervention is correlated with improvement in psychological well-beingSara eLazar0Mass Gen Hospital<br/>Individuals can improve their levels of psychological well-being through utilization of psychological interventions, including the practice of mindfulness meditation, which is defined as the non-judgmental awareness of experiences in the present moment. We recently reported that an 8-week Mindfulness-Based Stress Reduction (MBSR) course lead to increases in gray matter concentration in several brain areas, as detected with voxel-based morphometry of MPRAGE MRI scans, including the pons/raphe/locus coeruleus area of the brainstem. Given the role of the pons and raphe in mood and arousal, we hypothesized that changes in this region might underlie changes in well-being.<br/>A subset of fourteen healthy individuals from a previously published data set completed anatomical MRI and filled out the Psychological Well-Being (PWB) scale before and after MBSR participation. PWB change was used as the predictive regressor for changes in gray matter density within those brain regions that had previously shown pre- to post- MBSR changes. Results showed that scores on five PWB subscales as well as the PWB total score increased significantly over the MBSR course. The change was positively correlated with gray matter concentration increases in two symmetrically bilateral clusters in the brainstem. Those clusters appeared to contain the area of the pontine tegmentum, locus coeruleus, nucleus raphe pontis, and the sensory trigeminal nucleus. No clusters were negatively correlated with the change in PWB. This preliminary study suggests a neural correlate of enhanced psychological well-being. The identified brain areas include the sites of synthesis and release of the neurotransmitters norepinephrine and serotonin, which are involved in the modulation of arousal and mood, and have been related to a variety of affective functions as well as associated clinical dysfunctions.http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00033/fullBrain StemRaphe NucleiStress, PsychologicalmindfulnessWell-being |
| spellingShingle | Sara eLazar Change in brainstem gray matter concentration following a mindfulness-based intervention is correlated with improvement in psychological well-being Frontiers in Human Neuroscience Brain Stem Raphe Nuclei Stress, Psychological mindfulness Well-being |
| title | Change in brainstem gray matter concentration following a mindfulness-based intervention is correlated with improvement in psychological well-being |
| title_full | Change in brainstem gray matter concentration following a mindfulness-based intervention is correlated with improvement in psychological well-being |
| title_fullStr | Change in brainstem gray matter concentration following a mindfulness-based intervention is correlated with improvement in psychological well-being |
| title_full_unstemmed | Change in brainstem gray matter concentration following a mindfulness-based intervention is correlated with improvement in psychological well-being |
| title_short | Change in brainstem gray matter concentration following a mindfulness-based intervention is correlated with improvement in psychological well-being |
| title_sort | change in brainstem gray matter concentration following a mindfulness based intervention is correlated with improvement in psychological well being |
| topic | Brain Stem Raphe Nuclei Stress, Psychological mindfulness Well-being |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00033/full |
| work_keys_str_mv | AT saraelazar changeinbrainstemgraymatterconcentrationfollowingamindfulnessbasedinterventioniscorrelatedwithimprovementinpsychologicalwellbeing |