Novel 3-aminobenzofuran derivatives as multifunctional agents for the treatment of Alzheimer’s disease

Novel 3-aminobenzofuran derivatives as multifunctional agents for the treatment of Alzheimer’s disease

A novel multifunctional series of 3-aminobenzofuran derivatives 5a-p were designed and synthesized as potent inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The target compounds 5a-p were prepared via a three-step reaction, starting from 2-hydroxy benzonitrile. In vitro...

Full description

Bibliographic Details
Main Authors: Zaman Hasanvand, Rasoul Motahari, Hamid Nadri, Setareh Moghimi, Roham Foroumadi, Adileh Ayati, Tahmineh Akbarzadeh, Syed Nasir Abbas Bukhari, Alireza Foroumadi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Chemistry
Subjects:
Alzheheimer’s disease
acetylcholinesterase
neuroprotection
docking studies
ab-aggregation
3-amino benzofuran
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.882191/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.882191/full

Similar Items