Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1

Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a key enzyme in the biosynthesis of 17β-estradiol. Novel estrone-based compounds bearing various 15β-oxa-linked substituents and hydroxy, methoxy, benzyloxy, and sulfamate groups in position C3 as potential 17β-HSD1 inhibitors have been synthesiz...

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Bibliographic Details
Main Authors:	Bianka Edina Herman, Anita Kiss, János Wölfling, Erzsébet Mernyák, Mihály Szécsi, Gyula Schneider
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2019-01-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	michael addition substituted 15β-alkoxy-estrone derivatives 17β-hsd1 estrogen biosynthesis nadph and nadh
Online Access:	http://dx.doi.org/10.1080/14756366.2019.1634064

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