Synthesis of <sup>68</sup>Ga-Labeled cNGR-Based Glycopeptides and In Vivo Evaluation by PET Imaging

Synthesis of <sup>68</sup>Ga-Labeled cNGR-Based Glycopeptides and In Vivo Evaluation by PET Imaging

Tumor hypoxia induces angiogenesis, which is required for tumor cell survival. The aminopeptidase N receptor (APN/CD13) is an excellent marker of angiogenesis since it is overexpressed in angiogenic blood vessels and in tumor cells. Asparagine-glycine-arginine (NGR) peptide analogs bind selectively...

Full description

Bibliographic Details
Main Authors: Barbara Gyuricza, Judit P. Szabó, Viktória Arató, Noémi Dénes, Ágnes Szűcs, Katalin Berta, Adrienn Kis, Dániel Szücs, Viktória Forgács, Dezső Szikra, István Kertész, György Trencsényi, Anikó Fekete
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
radiopharmaceuticals
gallium-68
positron emission tomography (PET)
aminopeptidase N receptor (APN/CD13)
NGR peptide
Online Access:https://www.mdpi.com/1999-4923/13/12/2103

Internet

https://www.mdpi.com/1999-4923/13/12/2103

Similar Items