Viruses are a dominant driver of protein adaptation in mammals
Viruses interact with hundreds to thousands of proteins in mammals, yet adaptation against viruses has only been studied in a few proteins specialized in antiviral defense. Whether adaptation to viruses typically involves only specialized antiviral proteins or affects a broad array of virus-interact...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-05-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/12469 |
| _version_ | 1811227411075825664 |
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| author | David Enard Le Cai Carina Gwennap Dmitri A Petrov |
| author_facet | David Enard Le Cai Carina Gwennap Dmitri A Petrov |
| author_sort | David Enard |
| collection | DOAJ |
| description | Viruses interact with hundreds to thousands of proteins in mammals, yet adaptation against viruses has only been studied in a few proteins specialized in antiviral defense. Whether adaptation to viruses typically involves only specialized antiviral proteins or affects a broad array of virus-interacting proteins is unknown. Here, we analyze adaptation in ~1300 virus-interacting proteins manually curated from a set of 9900 proteins conserved in all sequenced mammalian genomes. We show that viruses (i) use the more evolutionarily constrained proteins within the cellular functions they interact with and that (ii) despite this high constraint, virus-interacting proteins account for a high proportion of all protein adaptation in humans and other mammals. Adaptation is elevated in virus-interacting proteins across all functional categories, including both immune and non-immune functions. We conservatively estimate that viruses have driven close to 30% of all adaptive amino acid changes in the part of the human proteome conserved within mammals. Our results suggest that viruses are one of the most dominant drivers of evolutionary change across mammalian and human proteomes. |
| first_indexed | 2024-04-12T09:42:10Z |
| format | Article |
| id | doaj.art-49b17dc9548a4749ad0013cf598c726d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:42:10Z |
| publishDate | 2016-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-49b17dc9548a4749ad0013cf598c726d2022-12-22T03:38:03ZengeLife Sciences Publications LtdeLife2050-084X2016-05-01510.7554/eLife.12469Viruses are a dominant driver of protein adaptation in mammalsDavid Enard0https://orcid.org/0000-0003-2634-8016Le Cai1Carina Gwennap2Dmitri A Petrov3Department of Biology, Stanford University, Stanford, United StatesDepartment of Biology, Stanford University, Stanford, United StatesDepartment of Biology, Stanford University, Stanford, United StatesDepartment of Biology, Stanford University, Stanford, United StatesViruses interact with hundreds to thousands of proteins in mammals, yet adaptation against viruses has only been studied in a few proteins specialized in antiviral defense. Whether adaptation to viruses typically involves only specialized antiviral proteins or affects a broad array of virus-interacting proteins is unknown. Here, we analyze adaptation in ~1300 virus-interacting proteins manually curated from a set of 9900 proteins conserved in all sequenced mammalian genomes. We show that viruses (i) use the more evolutionarily constrained proteins within the cellular functions they interact with and that (ii) despite this high constraint, virus-interacting proteins account for a high proportion of all protein adaptation in humans and other mammals. Adaptation is elevated in virus-interacting proteins across all functional categories, including both immune and non-immune functions. We conservatively estimate that viruses have driven close to 30% of all adaptive amino acid changes in the part of the human proteome conserved within mammals. Our results suggest that viruses are one of the most dominant drivers of evolutionary change across mammalian and human proteomes.https://elifesciences.org/articles/12469adaptive evolutionhuman evolutionhost/pathogen interactionsvirusesmammals |
| spellingShingle | David Enard Le Cai Carina Gwennap Dmitri A Petrov Viruses are a dominant driver of protein adaptation in mammals eLife adaptive evolution human evolution host/pathogen interactions viruses mammals |
| title | Viruses are a dominant driver of protein adaptation in mammals |
| title_full | Viruses are a dominant driver of protein adaptation in mammals |
| title_fullStr | Viruses are a dominant driver of protein adaptation in mammals |
| title_full_unstemmed | Viruses are a dominant driver of protein adaptation in mammals |
| title_short | Viruses are a dominant driver of protein adaptation in mammals |
| title_sort | viruses are a dominant driver of protein adaptation in mammals |
| topic | adaptive evolution human evolution host/pathogen interactions viruses mammals |
| url | https://elifesciences.org/articles/12469 |
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