Role of inflammatory factors and adipose tissue in pathogenesis of rheumatoid arthritis and osteoarthritis. Part II: Inflammatory background of osteoarthritis
Osteoarthritis is the most common rheumatoid disease. It may develop as a primary disease of the motor organ or as a secondary one in the course of other inflammatory joint diseases. Similarly to the majority of rheumatoid conditions, the pathogenesis of osteoarthritis has not been fully explaine...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2013-09-01
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| Series: | Journal of Ultrasonography |
| Subjects: | |
| Online Access: | http://jultrason.pl/index.php/issues/volume-13-no-54/role-of-inflammatory-factors-and-adipose-tissue-in-pathogenesis-of-rheumatoid-arthritis-and-osteoarthritis-part-ii-inflammatory-background-of-osteoarthritis?aid=173 |
| Summary: | Osteoarthritis is the most common rheumatoid disease. It may develop as a primary
disease of the motor organ or as a secondary one in the course of other inflammatory
joint diseases. Similarly to the majority of rheumatoid conditions, the pathogenesis of
osteoarthritis has not been fully explained. The fact that its development is determined
by adipocytokines, which are inflammatory mediators produced in the adipose tissue, has
been known for several years. Additionally, inflammatory processes taking place in the
adipose tissue that lead to degenerative changes are the main subject of studies conducted
by various immunological laboratories. Degenerative changes in patients with osteoarthritis
are frequently accompanied by secondary inflammation with cellular infiltrations
in the synovial membrane. In numerous cases, the intensification of inflammatory lesions
resembles changes seen in arthritis, particularly in rheumatoid arthritis, which inhibits
the differential diagnosis by means of imaging examinations. This may have significant
clinical implications, e.g. with respect to sonography, which is the basic imaging examination
in diagnosing rheumatoid arthritis, monitoring the efficacy of implemented treatment
or confirming remission. This article discusses the pathogenesis of three elements
of osteoarthritis, i.e. synovitis (due to the difficulties in differentiation of synovitis in the
course of osteoarthritis and in rheumatoid arthritis) as well as osteophytes and subchondral
sclerosis (due to the significance of the inflammatory factor in their development). |
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| ISSN: | 2084-8404 2451-070X |