Characterization of Bioactive Compounds from <i>Acacia concinna</i> and <i>Citrus limon</i>, Silver Nanoparticles’ Production by <i>A. concinna</i> Extract, and Their Biological Properties
The applications of bioactive compounds from medicinal plants as therapeutic drugs are largely increasing. The present study selected the bioactive compounds from <i>Acacia concinna</i> (<i>A. concinna</i>) and <i>Citrus limon</i> (<i>C. limon</i>) to...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/9/2715 |
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| author | Ibrahim Ahmed Shaikh Uday M. Muddapur Zabin K. Bagewadi Sneha Chiniwal Mohammed M. Ghoneim Mater H. Mahnashi Fahad Alsaikhan Deepak Yaraguppi Francois N. Niyonzima Sunil S. More Basheerahmed Abdulaziz Mannasaheb Amer Al Ali Abdulaziz Asiri Aejaz Abdullatif Khan S. M. Shakeel Iqubal |
| author_facet | Ibrahim Ahmed Shaikh Uday M. Muddapur Zabin K. Bagewadi Sneha Chiniwal Mohammed M. Ghoneim Mater H. Mahnashi Fahad Alsaikhan Deepak Yaraguppi Francois N. Niyonzima Sunil S. More Basheerahmed Abdulaziz Mannasaheb Amer Al Ali Abdulaziz Asiri Aejaz Abdullatif Khan S. M. Shakeel Iqubal |
| author_sort | Ibrahim Ahmed Shaikh |
| collection | DOAJ |
| description | The applications of bioactive compounds from medicinal plants as therapeutic drugs are largely increasing. The present study selected the bioactive compounds from <i>Acacia concinna</i> (<i>A. concinna</i>) and <i>Citrus limon</i> (<i>C. limon</i>) to assess their phytochemicals, proteins, and biological activity. The plant material was collected, and extraction performed as per the standard procedure. Qualitative analysis was undertaken, and identification of functional organic groups was performed by FTIR and HPLC. Antibacterial, anticancer, antioxidant, antihyperglycemic, antihyperlipidemic, and inhibition kinetics studies for enzymes were performed to assess the different biological activities. Flavonoids and phenols were present in a significant amount in both the selected plants. <i>A. concinna</i> showed significant antimicrobial activity against <i>Z. mobilis</i>, <i>E. coli</i>, and <i>S. aureus</i>, with minimum inhibition zones (MIZ) of 24, 22, and 20 mm, respectively. <i>C. limon</i> strongly inhibited all the tested pathogenic bacteria with maximum and minimum MIZ of 32 and 17 mm. <i>A. concinna</i> silver nanoparticles also exhibited potent antimicrobial activity. Both extracts showed substantial antioxidant, antihyperlipidemic, antidiabetic, anticancer (MCF-7), and anti-urease (antiulcer) properties. To conclude, these plants can be used to treat hyperlipidemia, diabetes, cancer, and gastrointestinal ulcers. They can also serve as antimicrobial and antioxidant agents. Thus, the studied plants must be exploited cost-effectively to generate therapeutic drugs for various diseases. |
| first_indexed | 2024-03-10T03:54:32Z |
| format | Article |
| id | doaj.art-49b1c2bcf9464c62a88ced25d4e2ab4e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:54:32Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-49b1c2bcf9464c62a88ced25d4e2ab4e2023-11-23T08:48:35ZengMDPI AGMolecules1420-30492022-04-01279271510.3390/molecules27092715Characterization of Bioactive Compounds from <i>Acacia concinna</i> and <i>Citrus limon</i>, Silver Nanoparticles’ Production by <i>A. concinna</i> Extract, and Their Biological PropertiesIbrahim Ahmed Shaikh0Uday M. Muddapur1Zabin K. Bagewadi2Sneha Chiniwal3Mohammed M. Ghoneim4Mater H. Mahnashi5Fahad Alsaikhan6Deepak Yaraguppi7Francois N. Niyonzima8Sunil S. More9Basheerahmed Abdulaziz Mannasaheb10Amer Al Ali11Abdulaziz Asiri12Aejaz Abdullatif Khan13S. M. Shakeel Iqubal14Department of Pharmacology, College of Pharmacy, Najran University, Najran 66462, Saudi ArabiaDepartment of Biotechnology, KLE Technological University, BVB Campus, Hubballi 580031, Karnataka, IndiaDepartment of Biotechnology, KLE Technological University, BVB Campus, Hubballi 580031, Karnataka, IndiaDepartment of Biotechnology, KLE Technological University, BVB Campus, Hubballi 580031, Karnataka, IndiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh 13713, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran 66462, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi ArabiaDepartment of Biotechnology, KLE Technological University, BVB Campus, Hubballi 580031, Karnataka, IndiaDepartment of Math, Science and PE, CE, University of Rwanda, Rwamagana 55, RwandaSchool of Basic and Applied Sciences, Dayananda Sagar University, Bangalore 560111, Karnataka, IndiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh 13713, Saudi ArabiaDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, University of Bisha, 255, Al Nakhil, Bisha 67714, Saudi ArabiaFaculty of Applied Medical Sciences, University of Bisha, 255, Al Nakhil, Bisha 67714, Saudi ArabiaDepartment of General Science, Ibn Sina National College for Medical Studies, Jeddah 21418, Saudi ArabiaDepartment of General Science, Ibn Sina National College for Medical Studies, Jeddah 21418, Saudi ArabiaThe applications of bioactive compounds from medicinal plants as therapeutic drugs are largely increasing. The present study selected the bioactive compounds from <i>Acacia concinna</i> (<i>A. concinna</i>) and <i>Citrus limon</i> (<i>C. limon</i>) to assess their phytochemicals, proteins, and biological activity. The plant material was collected, and extraction performed as per the standard procedure. Qualitative analysis was undertaken, and identification of functional organic groups was performed by FTIR and HPLC. Antibacterial, anticancer, antioxidant, antihyperglycemic, antihyperlipidemic, and inhibition kinetics studies for enzymes were performed to assess the different biological activities. Flavonoids and phenols were present in a significant amount in both the selected plants. <i>A. concinna</i> showed significant antimicrobial activity against <i>Z. mobilis</i>, <i>E. coli</i>, and <i>S. aureus</i>, with minimum inhibition zones (MIZ) of 24, 22, and 20 mm, respectively. <i>C. limon</i> strongly inhibited all the tested pathogenic bacteria with maximum and minimum MIZ of 32 and 17 mm. <i>A. concinna</i> silver nanoparticles also exhibited potent antimicrobial activity. Both extracts showed substantial antioxidant, antihyperlipidemic, antidiabetic, anticancer (MCF-7), and anti-urease (antiulcer) properties. To conclude, these plants can be used to treat hyperlipidemia, diabetes, cancer, and gastrointestinal ulcers. They can also serve as antimicrobial and antioxidant agents. Thus, the studied plants must be exploited cost-effectively to generate therapeutic drugs for various diseases.https://www.mdpi.com/1420-3049/27/9/2715medicinal plants<i>Acacia concinna</i><i>Citrus limon</i>phytochemical screeningantidiabeticanticancer |
| spellingShingle | Ibrahim Ahmed Shaikh Uday M. Muddapur Zabin K. Bagewadi Sneha Chiniwal Mohammed M. Ghoneim Mater H. Mahnashi Fahad Alsaikhan Deepak Yaraguppi Francois N. Niyonzima Sunil S. More Basheerahmed Abdulaziz Mannasaheb Amer Al Ali Abdulaziz Asiri Aejaz Abdullatif Khan S. M. Shakeel Iqubal Characterization of Bioactive Compounds from <i>Acacia concinna</i> and <i>Citrus limon</i>, Silver Nanoparticles’ Production by <i>A. concinna</i> Extract, and Their Biological Properties Molecules medicinal plants <i>Acacia concinna</i> <i>Citrus limon</i> phytochemical screening antidiabetic anticancer |
| title | Characterization of Bioactive Compounds from <i>Acacia concinna</i> and <i>Citrus limon</i>, Silver Nanoparticles’ Production by <i>A. concinna</i> Extract, and Their Biological Properties |
| title_full | Characterization of Bioactive Compounds from <i>Acacia concinna</i> and <i>Citrus limon</i>, Silver Nanoparticles’ Production by <i>A. concinna</i> Extract, and Their Biological Properties |
| title_fullStr | Characterization of Bioactive Compounds from <i>Acacia concinna</i> and <i>Citrus limon</i>, Silver Nanoparticles’ Production by <i>A. concinna</i> Extract, and Their Biological Properties |
| title_full_unstemmed | Characterization of Bioactive Compounds from <i>Acacia concinna</i> and <i>Citrus limon</i>, Silver Nanoparticles’ Production by <i>A. concinna</i> Extract, and Their Biological Properties |
| title_short | Characterization of Bioactive Compounds from <i>Acacia concinna</i> and <i>Citrus limon</i>, Silver Nanoparticles’ Production by <i>A. concinna</i> Extract, and Their Biological Properties |
| title_sort | characterization of bioactive compounds from i acacia concinna i and i citrus limon i silver nanoparticles production by i a concinna i extract and their biological properties |
| topic | medicinal plants <i>Acacia concinna</i> <i>Citrus limon</i> phytochemical screening antidiabetic anticancer |
| url | https://www.mdpi.com/1420-3049/27/9/2715 |
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