Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia
Resveratrol is a polyphenol that acts as antioxidants do, protecting the body against diseases, such as diabetes, cancer, heart disease, and neurodegenerative disorders, such as Alzheimer’s (AD) and Parkinson’s diseases (PD). In the present study, we report that the treatment of activated microglia...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/5/681 |
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| author | Rosa Calvello Chiara Porro Dario Domenico Lofrumento Melania Ruggiero Maria Antonietta Panaro Antonia Cianciulli |
| author_facet | Rosa Calvello Chiara Porro Dario Domenico Lofrumento Melania Ruggiero Maria Antonietta Panaro Antonia Cianciulli |
| author_sort | Rosa Calvello |
| collection | DOAJ |
| description | Resveratrol is a polyphenol that acts as antioxidants do, protecting the body against diseases, such as diabetes, cancer, heart disease, and neurodegenerative disorders, such as Alzheimer’s (AD) and Parkinson’s diseases (PD). In the present study, we report that the treatment of activated microglia with resveratrol after prolonged exposure to lipopolysaccharide is not only able to modulate pro-inflammatory responses, but it also up-regulates the expression of decoy receptors, IL-1R2 and ACKR2 (atypical chemokine receptors), also known as negative regulatory receptors, which are able to reduce the functional responses promoting the resolution of inflammation. This result might constitute a hitherto unknown anti-inflammatory mechanism exerted by resveratrol on activated microglia. |
| first_indexed | 2024-03-11T07:28:33Z |
| format | Article |
| id | doaj.art-49b21a5400dd44409adff68aba163157 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T07:28:33Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-49b21a5400dd44409adff68aba1631572023-11-17T07:26:46ZengMDPI AGCells2073-44092023-02-0112568110.3390/cells12050681Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated MicrogliaRosa Calvello0Chiara Porro1Dario Domenico Lofrumento2Melania Ruggiero3Maria Antonietta Panaro4Antonia Cianciulli5Department of Biosciences, Biotechnologies and Environment, University of Bari, I-70125 Bari, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, I-71100 Foggia, ItalyDepartment of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, I-73100 Lecce, ItalyDepartment of Biosciences, Biotechnologies and Environment, University of Bari, I-70125 Bari, ItalyDepartment of Biosciences, Biotechnologies and Environment, University of Bari, I-70125 Bari, ItalyDepartment of Biosciences, Biotechnologies and Environment, University of Bari, I-70125 Bari, ItalyResveratrol is a polyphenol that acts as antioxidants do, protecting the body against diseases, such as diabetes, cancer, heart disease, and neurodegenerative disorders, such as Alzheimer’s (AD) and Parkinson’s diseases (PD). In the present study, we report that the treatment of activated microglia with resveratrol after prolonged exposure to lipopolysaccharide is not only able to modulate pro-inflammatory responses, but it also up-regulates the expression of decoy receptors, IL-1R2 and ACKR2 (atypical chemokine receptors), also known as negative regulatory receptors, which are able to reduce the functional responses promoting the resolution of inflammation. This result might constitute a hitherto unknown anti-inflammatory mechanism exerted by resveratrol on activated microglia.https://www.mdpi.com/2073-4409/12/5/681microgliaresveratroldecoy receptorslipopolysaccharidecytokines |
| spellingShingle | Rosa Calvello Chiara Porro Dario Domenico Lofrumento Melania Ruggiero Maria Antonietta Panaro Antonia Cianciulli Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia Cells microglia resveratrol decoy receptors lipopolysaccharide cytokines |
| title | Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia |
| title_full | Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia |
| title_fullStr | Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia |
| title_full_unstemmed | Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia |
| title_short | Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia |
| title_sort | decoy receptors regulation by resveratrol in lipopolysaccharide activated microglia |
| topic | microglia resveratrol decoy receptors lipopolysaccharide cytokines |
| url | https://www.mdpi.com/2073-4409/12/5/681 |
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