Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

Abstract Background (S)-[18F]FETrp is a promising PET radiotracer for imaging IDO1 activity, one of the main enzymes involved in the tryptophan metabolism that plays a key role in several diseases including cancers. To date, the radiosynthesis of this tryptophan analogue remains highly challenging d...

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Bibliographic Details
Main Authors: Aurélie Maisonial-Besset, David Kryza, Klaus Kopka, Sophie Levesque, Emmanuel Moreau, Barbara Wenzel, Jean-Michel Chezal
Format: Article
Language:English
Published: SpringerOpen 2024-04-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
[18F]FETrp
IDO1
Fluorine-18
Radiochemistry
Radiofluorination
Automation
Online Access:https://doi.org/10.1186/s41181-024-00256-0

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