Direct and indirect therapeutic effect of traditional Chinese medicine as an add-on for non-proliferative diabetic retinopathy: a systematic review and meta-analysis
Abstract Background Diabetic retinopathy (DR) is the leading cause of blindness in many countries. The current treatment for non-proliferative DR (NPDR) using Western medicine (WM) alone is insufficient. At present, the combination of NPDR treatment with traditional Chinese medicine (TCM) and WM is...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | Chinese Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s13020-020-00380-4 |
| _version_ | 1819225946243203072 |
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| author | Xuedong An De Jin LiYun Duan Shenghui Zhao Rongrong Zhou Fengmei Lian Xiaolin Tong |
| author_facet | Xuedong An De Jin LiYun Duan Shenghui Zhao Rongrong Zhou Fengmei Lian Xiaolin Tong |
| author_sort | Xuedong An |
| collection | DOAJ |
| description | Abstract Background Diabetic retinopathy (DR) is the leading cause of blindness in many countries. The current treatment for non-proliferative DR (NPDR) using Western medicine (WM) alone is insufficient. At present, the combination of NPDR treatment with traditional Chinese medicine (TCM) and WM is universally applied. We aimed to evaluate the effectiveness and safety of TCM as an add-on for NPDR using a systematic review and meta-analysis. Method Data from randomized controlled trials (RCTs) of TCM for NPDR treatment along with WM before July 6, 2019, were collected from the China National Knowledge Infrastructure, Wanfang Database, China Biomedical Database, Pubmed, Embase, and Cochrane Library. Relevant data were extracted by two reviewers. I 2 statistics was adopted to appraise heterogeneity. If I 2 < 50% the fixed-effects model was employed, otherwise a random-effect model was employed. (PROSPERO: CRD42019134947) Result Eighteen RCTs (1522 patients) were included based on the inclusion and exclusion criteria. The results showed that compared with WM alone, TCM (including Compound Xueshuantong Capsule, Qiming Granule, and others) combined with WM for NPDR could improve the overall effiicacy [n = 1686, RR 1.24 (1.18,1.30), P < 0.00001, I 2 = 0%], and reduce the influence of risk factors related to NPDR, such as glycated hemoglobin level [n = 360, MD − 0.85 (− 1.28, − 0.41), P = 0.0001, I 2 = 72%], triglyceride (P < 0.00001), and total cholesterol (P = 0.0008). Moreover, no serious adverse events were reported. Conclusion Compared with WM alone, TCM + WM could significantly improve NPDR and also reduce the correlation levels of risk factors, such as hyperglycemia, dyslipidemia. However, the small sample included in the study might lead to a publication bias, and therefore, our results should be treated with caution. |
| first_indexed | 2024-12-23T10:17:40Z |
| format | Article |
| id | doaj.art-49b46469b934418493294cd077edf46d |
| institution | Directory Open Access Journal |
| issn | 1749-8546 |
| language | English |
| last_indexed | 2024-12-23T10:17:40Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj.art-49b46469b934418493294cd077edf46d2022-12-21T17:50:47ZengBMCChinese Medicine1749-85462020-09-0115111610.1186/s13020-020-00380-4Direct and indirect therapeutic effect of traditional Chinese medicine as an add-on for non-proliferative diabetic retinopathy: a systematic review and meta-analysisXuedong An0De Jin1LiYun Duan2Shenghui Zhao3Rongrong Zhou4Fengmei Lian5Xiaolin Tong6Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical SciencesAbstract Background Diabetic retinopathy (DR) is the leading cause of blindness in many countries. The current treatment for non-proliferative DR (NPDR) using Western medicine (WM) alone is insufficient. At present, the combination of NPDR treatment with traditional Chinese medicine (TCM) and WM is universally applied. We aimed to evaluate the effectiveness and safety of TCM as an add-on for NPDR using a systematic review and meta-analysis. Method Data from randomized controlled trials (RCTs) of TCM for NPDR treatment along with WM before July 6, 2019, were collected from the China National Knowledge Infrastructure, Wanfang Database, China Biomedical Database, Pubmed, Embase, and Cochrane Library. Relevant data were extracted by two reviewers. I 2 statistics was adopted to appraise heterogeneity. If I 2 < 50% the fixed-effects model was employed, otherwise a random-effect model was employed. (PROSPERO: CRD42019134947) Result Eighteen RCTs (1522 patients) were included based on the inclusion and exclusion criteria. The results showed that compared with WM alone, TCM (including Compound Xueshuantong Capsule, Qiming Granule, and others) combined with WM for NPDR could improve the overall effiicacy [n = 1686, RR 1.24 (1.18,1.30), P < 0.00001, I 2 = 0%], and reduce the influence of risk factors related to NPDR, such as glycated hemoglobin level [n = 360, MD − 0.85 (− 1.28, − 0.41), P = 0.0001, I 2 = 72%], triglyceride (P < 0.00001), and total cholesterol (P = 0.0008). Moreover, no serious adverse events were reported. Conclusion Compared with WM alone, TCM + WM could significantly improve NPDR and also reduce the correlation levels of risk factors, such as hyperglycemia, dyslipidemia. However, the small sample included in the study might lead to a publication bias, and therefore, our results should be treated with caution.http://link.springer.com/article/10.1186/s13020-020-00380-4Traditional Chinese medicineAdditional drugsNon-proliferative diabetic retinopathyMeta-analysisDirect treatmentIndirect treatment |
| spellingShingle | Xuedong An De Jin LiYun Duan Shenghui Zhao Rongrong Zhou Fengmei Lian Xiaolin Tong Direct and indirect therapeutic effect of traditional Chinese medicine as an add-on for non-proliferative diabetic retinopathy: a systematic review and meta-analysis Chinese Medicine Traditional Chinese medicine Additional drugs Non-proliferative diabetic retinopathy Meta-analysis Direct treatment Indirect treatment |
| title | Direct and indirect therapeutic effect of traditional Chinese medicine as an add-on for non-proliferative diabetic retinopathy: a systematic review and meta-analysis |
| title_full | Direct and indirect therapeutic effect of traditional Chinese medicine as an add-on for non-proliferative diabetic retinopathy: a systematic review and meta-analysis |
| title_fullStr | Direct and indirect therapeutic effect of traditional Chinese medicine as an add-on for non-proliferative diabetic retinopathy: a systematic review and meta-analysis |
| title_full_unstemmed | Direct and indirect therapeutic effect of traditional Chinese medicine as an add-on for non-proliferative diabetic retinopathy: a systematic review and meta-analysis |
| title_short | Direct and indirect therapeutic effect of traditional Chinese medicine as an add-on for non-proliferative diabetic retinopathy: a systematic review and meta-analysis |
| title_sort | direct and indirect therapeutic effect of traditional chinese medicine as an add on for non proliferative diabetic retinopathy a systematic review and meta analysis |
| topic | Traditional Chinese medicine Additional drugs Non-proliferative diabetic retinopathy Meta-analysis Direct treatment Indirect treatment |
| url | http://link.springer.com/article/10.1186/s13020-020-00380-4 |
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