Methacrylic acid as a potential monomer for molecular imprinting: A review of recent advances
Molecular Imprinted polymers (MIPs) are man-made receptors for the specific molecules of drug delivery use. These polymers are meant for their site-specificity and recognition. Molecular Imprinting Technique (MITs) comprised of Template, Functional Monomers, Cross-Linkers, Initiators, and solvents....
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Results in Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590048X23000171 |
| _version_ | 1827926486301016064 |
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| author | Kumar Nishchaya Vineet Kumar Rai Himanshu Bansode |
| author_facet | Kumar Nishchaya Vineet Kumar Rai Himanshu Bansode |
| author_sort | Kumar Nishchaya |
| collection | DOAJ |
| description | Molecular Imprinted polymers (MIPs) are man-made receptors for the specific molecules of drug delivery use. These polymers are meant for their site-specificity and recognition. Molecular Imprinting Technique (MITs) comprised of Template, Functional Monomers, Cross-Linkers, Initiators, and solvents. Methacrylic acid (MAA) has shown its potential utility as a monomer for molecular imprinting. It is the most used and preferred monomer with great future potential. Therefore, this review highlights different aspects of MAA as a universal functional monomer that is believed to happen due to its flexibility, robustness, durability, etc. Computational Methods exhibit MAA as one of the most compatible monomers showing excellent binding efficacy with a wide range of drug molecules. A comprehensive assessment of its physiochemical, interactive, and binding properties is deliberately compiled along with the biodegradability of MAA. This review also highlights the future prospects, recent advances, and current applications, including MAA-based Nano MIPs, and trigger-responsive MIPs related to drug delivery. The comparative studies showed that MIPs and Non-MIPs have a drastic difference in their drug release either controlled or sustained. Eventually, the trend pattern associated with drug classification and disease diagnosis in the past decade showcases the tremendous utility of MAA-MIP in various fields of pharmaceutical and medical importance. |
| first_indexed | 2024-03-13T05:39:24Z |
| format | Article |
| id | doaj.art-49b53a20f4b9407c829a7ba8895aebfb |
| institution | Directory Open Access Journal |
| issn | 2590-048X |
| language | English |
| last_indexed | 2024-03-13T05:39:24Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Materials |
| spelling | doaj.art-49b53a20f4b9407c829a7ba8895aebfb2023-06-14T04:34:00ZengElsevierResults in Materials2590-048X2023-06-0118100379Methacrylic acid as a potential monomer for molecular imprinting: A review of recent advancesKumar Nishchaya0Vineet Kumar Rai1Himanshu Bansode2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India; Corresponding author. Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.Department of Pharmaceutics, School of Pharmaceutical Sciences, Shiksha ‘O’ Anusandhan, Bhubaneshwar, Odisha, 751030, IndiaDepartment of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, 226020, IndiaMolecular Imprinted polymers (MIPs) are man-made receptors for the specific molecules of drug delivery use. These polymers are meant for their site-specificity and recognition. Molecular Imprinting Technique (MITs) comprised of Template, Functional Monomers, Cross-Linkers, Initiators, and solvents. Methacrylic acid (MAA) has shown its potential utility as a monomer for molecular imprinting. It is the most used and preferred monomer with great future potential. Therefore, this review highlights different aspects of MAA as a universal functional monomer that is believed to happen due to its flexibility, robustness, durability, etc. Computational Methods exhibit MAA as one of the most compatible monomers showing excellent binding efficacy with a wide range of drug molecules. A comprehensive assessment of its physiochemical, interactive, and binding properties is deliberately compiled along with the biodegradability of MAA. This review also highlights the future prospects, recent advances, and current applications, including MAA-based Nano MIPs, and trigger-responsive MIPs related to drug delivery. The comparative studies showed that MIPs and Non-MIPs have a drastic difference in their drug release either controlled or sustained. Eventually, the trend pattern associated with drug classification and disease diagnosis in the past decade showcases the tremendous utility of MAA-MIP in various fields of pharmaceutical and medical importance.http://www.sciencedirect.com/science/article/pii/S2590048X23000171Methacrylic acidMolecular imprinted polymerMonomerDrug delivery |
| spellingShingle | Kumar Nishchaya Vineet Kumar Rai Himanshu Bansode Methacrylic acid as a potential monomer for molecular imprinting: A review of recent advances Results in Materials Methacrylic acid Molecular imprinted polymer Monomer Drug delivery |
| title | Methacrylic acid as a potential monomer for molecular imprinting: A review of recent advances |
| title_full | Methacrylic acid as a potential monomer for molecular imprinting: A review of recent advances |
| title_fullStr | Methacrylic acid as a potential monomer for molecular imprinting: A review of recent advances |
| title_full_unstemmed | Methacrylic acid as a potential monomer for molecular imprinting: A review of recent advances |
| title_short | Methacrylic acid as a potential monomer for molecular imprinting: A review of recent advances |
| title_sort | methacrylic acid as a potential monomer for molecular imprinting a review of recent advances |
| topic | Methacrylic acid Molecular imprinted polymer Monomer Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2590048X23000171 |
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