Laser-Processed PEN with Au Nanowires Array: A Biocompatibility Assessment
Although many noble metals are known for their antibacterial properties against the most common pathogens, such as <i>Escherichia coli</i> and <i>Staphylococcus epidermidis</i>, their effect on healthy cells can be toxic. For this reason, the choice of metals that preserve th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/18/10953 |
| _version_ | 1797486959816343552 |
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| author | Jana Pryjmaková Barbora Vokatá Petr Slepička Jakub Siegel |
| author_facet | Jana Pryjmaková Barbora Vokatá Petr Slepička Jakub Siegel |
| author_sort | Jana Pryjmaková |
| collection | DOAJ |
| description | Although many noble metals are known for their antibacterial properties against the most common pathogens, such as <i>Escherichia coli</i> and <i>Staphylococcus epidermidis</i>, their effect on healthy cells can be toxic. For this reason, the choice of metals that preserve the antibacterial effect while being biocompatible with health cells is very important. This work aims to validate the effect of gold on the biocompatibility of Au/Ag nanowires, as assessed in our previous study. Polyethylene naphthalate (PEN) was treated with a KrF excimer laser to provide specific laser-induced periodic structures. Then, Au was deposited onto the modified PEN via a vacuum evaporation method. Atomic force microscopy and scanning electron microscopy revealed the dependence of the surface morphology on the incidence angle of the laser beam. A resazurin assay cytotoxicity test confirmed safety against healthy human cells and even cell proliferation was observed after 72 h of incubation. We have obtained satisfactory results, demonstrating that monometallic Au nanowires can be applied in biomedical applications and provide the biocompatibility of bimetallic Au/AgNWs. |
| first_indexed | 2024-03-09T23:41:45Z |
| format | Article |
| id | doaj.art-49b54b52760e49a18648e50c85fe20a0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:41:45Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-49b54b52760e49a18648e50c85fe20a02023-11-23T16:51:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123181095310.3390/ijms231810953Laser-Processed PEN with Au Nanowires Array: A Biocompatibility AssessmentJana Pryjmaková0Barbora Vokatá1Petr Slepička2Jakub Siegel3Department of Solid-State Engineering, University of Chemistry and Technology Prague, 166 28 Prague, Czech RepublicDepartment of Microbiology, University of Chemistry and Technology Prague, 166 28 Prague, Czech RepublicDepartment of Solid-State Engineering, University of Chemistry and Technology Prague, 166 28 Prague, Czech RepublicDepartment of Solid-State Engineering, University of Chemistry and Technology Prague, 166 28 Prague, Czech RepublicAlthough many noble metals are known for their antibacterial properties against the most common pathogens, such as <i>Escherichia coli</i> and <i>Staphylococcus epidermidis</i>, their effect on healthy cells can be toxic. For this reason, the choice of metals that preserve the antibacterial effect while being biocompatible with health cells is very important. This work aims to validate the effect of gold on the biocompatibility of Au/Ag nanowires, as assessed in our previous study. Polyethylene naphthalate (PEN) was treated with a KrF excimer laser to provide specific laser-induced periodic structures. Then, Au was deposited onto the modified PEN via a vacuum evaporation method. Atomic force microscopy and scanning electron microscopy revealed the dependence of the surface morphology on the incidence angle of the laser beam. A resazurin assay cytotoxicity test confirmed safety against healthy human cells and even cell proliferation was observed after 72 h of incubation. We have obtained satisfactory results, demonstrating that monometallic Au nanowires can be applied in biomedical applications and provide the biocompatibility of bimetallic Au/AgNWs.https://www.mdpi.com/1422-0067/23/18/10953laser-treatmentperiodic structuresgold nanowiresnanocompositesbiocompatibility |
| spellingShingle | Jana Pryjmaková Barbora Vokatá Petr Slepička Jakub Siegel Laser-Processed PEN with Au Nanowires Array: A Biocompatibility Assessment International Journal of Molecular Sciences laser-treatment periodic structures gold nanowires nanocomposites biocompatibility |
| title | Laser-Processed PEN with Au Nanowires Array: A Biocompatibility Assessment |
| title_full | Laser-Processed PEN with Au Nanowires Array: A Biocompatibility Assessment |
| title_fullStr | Laser-Processed PEN with Au Nanowires Array: A Biocompatibility Assessment |
| title_full_unstemmed | Laser-Processed PEN with Au Nanowires Array: A Biocompatibility Assessment |
| title_short | Laser-Processed PEN with Au Nanowires Array: A Biocompatibility Assessment |
| title_sort | laser processed pen with au nanowires array a biocompatibility assessment |
| topic | laser-treatment periodic structures gold nanowires nanocomposites biocompatibility |
| url | https://www.mdpi.com/1422-0067/23/18/10953 |
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