The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming

The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming

Summary: Evolutionarily conserved SCAN (named after SRE-ZBP, CTfin51, AW-1, and Number 18 cDNA)-domain-containing zinc finger transcription factors (ZSCAN) have been found in both mouse and human genomes. Zscan4 is transiently expressed during zygotic genome activation (ZGA) in preimplantation embry...

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Bibliographic Details
Main Authors: Zhou-Li Cheng, Meng-Li Zhang, Huai-Peng Lin, Chao Gao, Jun-Bin Song, Zhihong Zheng, Linpeng Li, Yanan Zhang, Xiaoqi Shen, Hao Zhang, Zhenghui Huang, Wuqiang Zhan, Cheng Zhang, Xu Hu, Yi-Ping Sun, Lubing Jiang, Lei Sun, Yanhui Xu, Chen Yang, Yuanlong Ge, Yong Zhao, Xingguo Liu, Hui Yang, Pengyuan Liu, Xing Guo, Kun-Liang Guan, Yue Xiong, Mingliang Zhang, Dan Ye
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
ZSCAN4
TET2
SCAN domain
induced pluripotent stem cells
iPSCs
metabolic rewiring
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308585

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