Drug Resistance Patterns among Hospitalized Tuberculous Patients in Rio de Janeiro, Brazil, 1993-1994
The purpose of this study was to analyze the prevalence and risk factors for drug resistance among hospitalized patients in two tertiary care centers, an acquired immunodeficiency syndrome (AIDS) reference center and a sanatorium, in Rio de Janeiro, Brazil. From 1993-1994, 389 patients were diagnose...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
1999-07-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000400021&tlng=en |
| _version_ | 1797718141577461760 |
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| author | FCO Fandinho AL Kritski C Hofer H Conde Jr RMC Ferreira MG Silva LS Fonseca |
| author_facet | FCO Fandinho AL Kritski C Hofer H Conde Jr RMC Ferreira MG Silva LS Fonseca |
| author_sort | FCO Fandinho |
| collection | DOAJ |
| description | The purpose of this study was to analyze the prevalence and risk factors for drug resistance among hospitalized patients in two tertiary care centers, an acquired immunodeficiency syndrome (AIDS) reference center and a sanatorium, in Rio de Janeiro, Brazil. From 1993-1994, 389 patients were diagnosed as having tuberculosis (TB). Isolates from 265 patients were tested for in vitro susceptibility to rifampin and isoniazid. Resistance to one or more drugs was detected in 44 patients (16.6%) and was significantly more common among recurrent cases in both hospitals (p=0.03 in the AIDS center and p=0.001 in the sanatorium). Twenty seven patients (10.2%) had isolates resistant to both isoniazid and rifampin. Multi-drug resistance was associated with human immunodeficiency virus (HIV) infection among patients who had never been treated for TB. In conclusion, drug-resistant TB is high in hospitalized patients in Rio de Janeiro, especially among HIV infected patients. Therefore, measures to control TB and prevent nosocomial transmission need urgently to be set up in the Brazilian hospitals. |
| first_indexed | 2024-03-12T08:46:44Z |
| format | Article |
| id | doaj.art-49b5793351eb4e229c133eefdd37805a |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:46:44Z |
| publishDate | 1999-07-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-49b5793351eb4e229c133eefdd37805a2023-09-02T16:26:06ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80601999-07-0194454354710.1590/S0074-02761999000400021Drug Resistance Patterns among Hospitalized Tuberculous Patients in Rio de Janeiro, Brazil, 1993-1994FCO Fandinho0AL Kritski1C Hofer2H Conde Jr3RMC Ferreira4MG Silva5LS Fonseca6FiocruzUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroInstituto Estadual de Doenças do Tórax Ari ParreirasUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroThe purpose of this study was to analyze the prevalence and risk factors for drug resistance among hospitalized patients in two tertiary care centers, an acquired immunodeficiency syndrome (AIDS) reference center and a sanatorium, in Rio de Janeiro, Brazil. From 1993-1994, 389 patients were diagnosed as having tuberculosis (TB). Isolates from 265 patients were tested for in vitro susceptibility to rifampin and isoniazid. Resistance to one or more drugs was detected in 44 patients (16.6%) and was significantly more common among recurrent cases in both hospitals (p=0.03 in the AIDS center and p=0.001 in the sanatorium). Twenty seven patients (10.2%) had isolates resistant to both isoniazid and rifampin. Multi-drug resistance was associated with human immunodeficiency virus (HIV) infection among patients who had never been treated for TB. In conclusion, drug-resistant TB is high in hospitalized patients in Rio de Janeiro, especially among HIV infected patients. Therefore, measures to control TB and prevent nosocomial transmission need urgently to be set up in the Brazilian hospitals.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000400021&tlng=entuberculosisdrug resistancehuman immunodeficiency virus (HIV) infectioninpatients |
| spellingShingle | FCO Fandinho AL Kritski C Hofer H Conde Jr RMC Ferreira MG Silva LS Fonseca Drug Resistance Patterns among Hospitalized Tuberculous Patients in Rio de Janeiro, Brazil, 1993-1994 Memorias do Instituto Oswaldo Cruz tuberculosis drug resistance human immunodeficiency virus (HIV) infection inpatients |
| title | Drug Resistance Patterns among Hospitalized Tuberculous Patients in Rio de Janeiro, Brazil, 1993-1994 |
| title_full | Drug Resistance Patterns among Hospitalized Tuberculous Patients in Rio de Janeiro, Brazil, 1993-1994 |
| title_fullStr | Drug Resistance Patterns among Hospitalized Tuberculous Patients in Rio de Janeiro, Brazil, 1993-1994 |
| title_full_unstemmed | Drug Resistance Patterns among Hospitalized Tuberculous Patients in Rio de Janeiro, Brazil, 1993-1994 |
| title_short | Drug Resistance Patterns among Hospitalized Tuberculous Patients in Rio de Janeiro, Brazil, 1993-1994 |
| title_sort | drug resistance patterns among hospitalized tuberculous patients in rio de janeiro brazil 1993 1994 |
| topic | tuberculosis drug resistance human immunodeficiency virus (HIV) infection inpatients |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000400021&tlng=en |
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