Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency
Growth hormone deficiency (GHD) has become a serious healthcare burden, and presents a huge impact on the physical and mental health of patients. Here, we developed an actively separated microneedle patch (PAA/NaHCO3-Silk MN) based on silk protein for sustained release of recombinant human growth ho...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383522002039 |
| _version_ | 1811172021947596800 |
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| author | Li Yang Qingyun Liu Xinhui Wang Nansha Gao Xiuzhen Li Hongzhong Chen Lin Mei Xiaowei Zeng |
| author_facet | Li Yang Qingyun Liu Xinhui Wang Nansha Gao Xiuzhen Li Hongzhong Chen Lin Mei Xiaowei Zeng |
| author_sort | Li Yang |
| collection | DOAJ |
| description | Growth hormone deficiency (GHD) has become a serious healthcare burden, and presents a huge impact on the physical and mental health of patients. Here, we developed an actively separated microneedle patch (PAA/NaHCO3-Silk MN) based on silk protein for sustained release of recombinant human growth hormone (rhGH). Silk protein, as a friendly carrier material for proteins, could be constructed in mild full-water conditions and ensure the activity of rhGH. After manually pressing PAA/NaHCO3-Silk MN patch to skin for 1 min, active separation is achieved by absorbing the interstitial fluid (ISF) to trigger HCO3‒ in the active backing layer to produce carbon dioxide gas (CO2). In rats, the MN patch could maintain the sustained release of rhGH for more than 7 days, and produce similar effects as daily subcutaneous (S.C.) injections of rhGH in promoting height and weight with well tolerated. Moreover, the PAA/NaHCO3-Silk MN patch with the potential of painless self-administration, does not require cold chain transportation and storage possess great economic benefits. Overall, the PAA/NaHCO3-Silk MN patch can significantly improve patient compliance and increase the availability of drugs, meet current unmet clinical needs, improve clinical treatment effects of GHD patients. |
| first_indexed | 2024-04-10T17:23:35Z |
| format | Article |
| id | doaj.art-49b5af6b4e524e509fd172c47424cd44 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-04-10T17:23:35Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-49b5af6b4e524e509fd172c47424cd442023-02-05T04:15:54ZengElsevierActa Pharmaceutica Sinica B2211-38352023-01-01131344358Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiencyLi Yang0Qingyun Liu1Xinhui Wang2Nansha Gao3Xiuzhen Li4Hongzhong Chen5Lin Mei6Xiaowei Zeng7Institute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaInstitute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaInstitute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaInstitute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaDepartment of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, ChinaInstitute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaInstitute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China; Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China; Corresponding authors.Institute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China; Corresponding authors.Growth hormone deficiency (GHD) has become a serious healthcare burden, and presents a huge impact on the physical and mental health of patients. Here, we developed an actively separated microneedle patch (PAA/NaHCO3-Silk MN) based on silk protein for sustained release of recombinant human growth hormone (rhGH). Silk protein, as a friendly carrier material for proteins, could be constructed in mild full-water conditions and ensure the activity of rhGH. After manually pressing PAA/NaHCO3-Silk MN patch to skin for 1 min, active separation is achieved by absorbing the interstitial fluid (ISF) to trigger HCO3‒ in the active backing layer to produce carbon dioxide gas (CO2). In rats, the MN patch could maintain the sustained release of rhGH for more than 7 days, and produce similar effects as daily subcutaneous (S.C.) injections of rhGH in promoting height and weight with well tolerated. Moreover, the PAA/NaHCO3-Silk MN patch with the potential of painless self-administration, does not require cold chain transportation and storage possess great economic benefits. Overall, the PAA/NaHCO3-Silk MN patch can significantly improve patient compliance and increase the availability of drugs, meet current unmet clinical needs, improve clinical treatment effects of GHD patients.http://www.sciencedirect.com/science/article/pii/S2211383522002039MicroneedleSilk proteinSelf-administrationSustained-releaseActively separatedGrowth hormone deficiency |
| spellingShingle | Li Yang Qingyun Liu Xinhui Wang Nansha Gao Xiuzhen Li Hongzhong Chen Lin Mei Xiaowei Zeng Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency Acta Pharmaceutica Sinica B Microneedle Silk protein Self-administration Sustained-release Actively separated Growth hormone deficiency |
| title | Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency |
| title_full | Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency |
| title_fullStr | Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency |
| title_full_unstemmed | Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency |
| title_short | Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency |
| title_sort | actively separated microneedle patch for sustained release of growth hormone to treat growth hormone deficiency |
| topic | Microneedle Silk protein Self-administration Sustained-release Actively separated Growth hormone deficiency |
| url | http://www.sciencedirect.com/science/article/pii/S2211383522002039 |
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