Treatment methods for patients suffering from acute lymphoblastic leukemia (all) - a brief review
Introduction and purpose: Acute lymphoblastic leukemia is a medical condition with underlying abnormal proliferation of cells of the lymphoid system which are blocked at an early stage of differentiation. As a result of impaired lymphocyte maturation, the proliferation and accumulation of immature...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2023-08-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/45184 |
| _version_ | 1797740914825756672 |
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| author | Zuzanna Czudy Wojciech Pawęska Jan Radwański Hanna Dominik Marika Polatowska Anna Gadomska Justyna Kurek Rafał Gorzyński Michał Garstka Justyna Molczyk-Sieńczak |
| author_facet | Zuzanna Czudy Wojciech Pawęska Jan Radwański Hanna Dominik Marika Polatowska Anna Gadomska Justyna Kurek Rafał Gorzyński Michał Garstka Justyna Molczyk-Sieńczak |
| author_sort | Zuzanna Czudy |
| collection | DOAJ |
| description |
Introduction and purpose: Acute lymphoblastic leukemia is a medical condition with underlying abnormal proliferation of cells of the lymphoid system which are blocked at an early stage of differentiation. As a result of impaired lymphocyte maturation, the proliferation and accumulation of immature blastic cells, derived from tumor-transformed bone marrow precursor cells, develop in the bone marrow. The infiltration of the bone marrow by leukemic cells results in failure of normal hematopoiesis, with subsequent anemia, thrombocytopenia and neutropenia. Acute lymphoblastic leukemia is among the most aggressive proliferative diseases, and survival time is a few to several weeks without appropriate treatment.
Materials and methods: The literature available on PubMed was reviewed using the words “acute lymphoblastic leukemia ”, “ALL”, “acute lymphoblastic leukemia treatment”.
Summary: Acute lymphoblastic leukemia was managed with a chemotherapeutic drug combination for several years, with median overall survival of approximately 80% for all newly diagnosed cases. Patients with higher-risk relapses receive more intensive treatment, while patients with more favorable outcomes can avoid more toxic effects. Multicenter randomized controlled trials conducted by international collaborative efforts are helping to advance overall survival by exploring novel treatments. Hope for the future of leukemia therapy is defining the underlying molecular trails in the pathogenesis of the disease and clarifying host pharmacogenetic factors further. If successful, these efforts will allow the identification of new genes with candidate proteins for targeted therapies.
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| first_indexed | 2024-03-12T14:19:22Z |
| format | Article |
| id | doaj.art-49b5e38aa15446a49e9fc71e63b83cd4 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-03-12T14:19:22Z |
| publishDate | 2023-08-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-49b5e38aa15446a49e9fc71e63b83cd42023-08-19T10:48:24ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062023-08-0144110.12775/JEHS.2023.44.01.005Treatment methods for patients suffering from acute lymphoblastic leukemia (all) - a brief reviewZuzanna Czudy0Wojciech Pawęska1Jan Radwański2Hanna Dominik3Marika Polatowska4Anna Gadomska5Justyna Kurek6Rafał Gorzyński7Michał Garstka8Justyna Molczyk-Sieńczak9University Hospital, Collegium Medicum University of Zielona Gora, Zyty 28, 65-046 Zielona Gora, Poland,District Hospital, Krakowska 3, 32-700, Bochnia, PolandProvincial Specialist Hospital No. 4, Legionow 10, 41-902 Bytom, PolandUniversity Hospital, Zyty 26, 65-046 Zielona Gora, Poland,Collegium Medicum University of Zielona Gora, Zyty 28, Zielona Gora 65-046, Poland,University Hospital, Zyty 26, 65-046 Zielona Gora, PolandClinical Hospital No. 2, Lwowska 60, 35-301 Rzeszow, Clinical Hospital, Collegium Medicum University of Poznan, Dluga ½, 61-848 Poznan, Poland, Medical Center HCP, 28 Czerwca 1956 r. 194, 61-485 PoznanNZOZ Alicja Ulanecka, Moscickiego 14, 33-100 Tarnow, Poland Introduction and purpose: Acute lymphoblastic leukemia is a medical condition with underlying abnormal proliferation of cells of the lymphoid system which are blocked at an early stage of differentiation. As a result of impaired lymphocyte maturation, the proliferation and accumulation of immature blastic cells, derived from tumor-transformed bone marrow precursor cells, develop in the bone marrow. The infiltration of the bone marrow by leukemic cells results in failure of normal hematopoiesis, with subsequent anemia, thrombocytopenia and neutropenia. Acute lymphoblastic leukemia is among the most aggressive proliferative diseases, and survival time is a few to several weeks without appropriate treatment. Materials and methods: The literature available on PubMed was reviewed using the words “acute lymphoblastic leukemia ”, “ALL”, “acute lymphoblastic leukemia treatment”. Summary: Acute lymphoblastic leukemia was managed with a chemotherapeutic drug combination for several years, with median overall survival of approximately 80% for all newly diagnosed cases. Patients with higher-risk relapses receive more intensive treatment, while patients with more favorable outcomes can avoid more toxic effects. Multicenter randomized controlled trials conducted by international collaborative efforts are helping to advance overall survival by exploring novel treatments. Hope for the future of leukemia therapy is defining the underlying molecular trails in the pathogenesis of the disease and clarifying host pharmacogenetic factors further. If successful, these efforts will allow the identification of new genes with candidate proteins for targeted therapies. https://apcz.umk.pl/JEHS/article/view/45184acute lymphoblastic leukemiaCAR Tchemiotherapybone marrowagressive proliferative disease |
| spellingShingle | Zuzanna Czudy Wojciech Pawęska Jan Radwański Hanna Dominik Marika Polatowska Anna Gadomska Justyna Kurek Rafał Gorzyński Michał Garstka Justyna Molczyk-Sieńczak Treatment methods for patients suffering from acute lymphoblastic leukemia (all) - a brief review Journal of Education, Health and Sport acute lymphoblastic leukemia CAR T chemiotherapy bone marrow agressive proliferative disease |
| title | Treatment methods for patients suffering from acute lymphoblastic leukemia (all) - a brief review |
| title_full | Treatment methods for patients suffering from acute lymphoblastic leukemia (all) - a brief review |
| title_fullStr | Treatment methods for patients suffering from acute lymphoblastic leukemia (all) - a brief review |
| title_full_unstemmed | Treatment methods for patients suffering from acute lymphoblastic leukemia (all) - a brief review |
| title_short | Treatment methods for patients suffering from acute lymphoblastic leukemia (all) - a brief review |
| title_sort | treatment methods for patients suffering from acute lymphoblastic leukemia all a brief review |
| topic | acute lymphoblastic leukemia CAR T chemiotherapy bone marrow agressive proliferative disease |
| url | https://apcz.umk.pl/JEHS/article/view/45184 |
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