Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats
Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (S<sub>BET</sub> ~2700 m<sup>2</sup>/g) was used as a medical...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/7/3174 |
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| author | Elisaveta Snezhkova Natalia Rodionova Dennis Bilko Joaquin Silvestre-Albero Alexey Sydorenko Olga Yurchenko Marharyta Pakharenko Mo Alavijeh Kvitoslava Bardakhivska Natalia Riabchenko Vladimir Nikolaev |
| author_facet | Elisaveta Snezhkova Natalia Rodionova Dennis Bilko Joaquin Silvestre-Albero Alexey Sydorenko Olga Yurchenko Marharyta Pakharenko Mo Alavijeh Kvitoslava Bardakhivska Natalia Riabchenko Vladimir Nikolaev |
| author_sort | Elisaveta Snezhkova |
| collection | DOAJ |
| description | Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (S<sub>BET</sub> ~2700 m<sup>2</sup>/g) was used as a medical countermeasure (MCM) to acute radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow (BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality of ARS treatment. |
| first_indexed | 2024-03-10T12:39:30Z |
| format | Article |
| id | doaj.art-49b66989626f40149a2131aa68584ff6 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T12:39:30Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-49b66989626f40149a2131aa68584ff62023-11-21T13:57:51ZengMDPI AGApplied Sciences2076-34172021-04-01117317410.3390/app11073174Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in RatsElisaveta Snezhkova0Natalia Rodionova1Dennis Bilko2Joaquin Silvestre-Albero3Alexey Sydorenko4Olga Yurchenko5Marharyta Pakharenko6Mo Alavijeh7Kvitoslava Bardakhivska8Natalia Riabchenko9Vladimir Nikolaev10Department of Means & Methods of Adsorptive Therapy, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 03022 Kyiv, UkraineDepartment of Radiobiology and Radioecology, Institute for Nuclear Research of National Academy of Sciences of Ukraine, 02000 Kyiv, UkraineCenter of Molecular and Cell Research, National University of Kyiv-Mohyla Academy, 04070 Kyiv, UkraineLaboratorio de Materiales Avanzados, Departamento de Química Inorgánica-Instituto Universitario de Materiales, Universidad de Alicante, E-03690 San Vicente del Raspeig, SpainDepartment of Means & Methods of Adsorptive Therapy, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 03022 Kyiv, UkraineDepartment of Means & Methods of Adsorptive Therapy, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 03022 Kyiv, UkraineCenter of Molecular and Cell Research, National University of Kyiv-Mohyla Academy, 04070 Kyiv, UkrainePharmidex Pharmaceutical Services Ltd., London EC2V 8AU, UKDepartment of Means & Methods of Adsorptive Therapy, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 03022 Kyiv, UkraineDepartment of Radiobiology and Radioecology, Institute for Nuclear Research of National Academy of Sciences of Ukraine, 02000 Kyiv, UkraineDepartment of Means & Methods of Adsorptive Therapy, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 03022 Kyiv, UkraineActivated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (S<sub>BET</sub> ~2700 m<sup>2</sup>/g) was used as a medical countermeasure (MCM) to acute radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow (BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality of ARS treatment.https://www.mdpi.com/2076-3417/11/7/3174activated charcoalenterosorbentacute radiation sicknessrats |
| spellingShingle | Elisaveta Snezhkova Natalia Rodionova Dennis Bilko Joaquin Silvestre-Albero Alexey Sydorenko Olga Yurchenko Marharyta Pakharenko Mo Alavijeh Kvitoslava Bardakhivska Natalia Riabchenko Vladimir Nikolaev Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats Applied Sciences activated charcoal enterosorbent acute radiation sickness rats |
| title | Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats |
| title_full | Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats |
| title_fullStr | Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats |
| title_full_unstemmed | Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats |
| title_short | Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats |
| title_sort | orally administered activated charcoal as a medical countermeasure for acute radiation syndrome in rats |
| topic | activated charcoal enterosorbent acute radiation sickness rats |
| url | https://www.mdpi.com/2076-3417/11/7/3174 |
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